Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"radiosurgery"”.
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A Comprehensive Patient Education Video for Radiosurgery of the Central Nervous System
A supplemental video file was submitted as part of the thesis approval, but it was not uploaded due to size restrictions at the time of submission. The file is not available.
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Development of Fully Balanced Ssfp and Computer Vision Applications For Mri-Assisted Radiosurgery (Mars)
… and help expand the access of MRI-assited radiosurgery (MARS) for LDR prostate brachytherapy from major academic hospitals to the community setting.</p>
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Dynamic photon painting
Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Currently, most radiosurgeries …
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Radiotherapy for head and neck paragangliomas: A 10 year retrospective review 2005-2014 at Groote Schuur Hospital and UCT Private academic hospital
… decades there has been increasing evidence that radiosurgery and radiotherapy management of skull-base paragangliomas is as effective as microsurgical resection and carries less morbidity. This 10 year retrospective review of 24 patients in a single institution, treated over 10 years assesses …
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New Optimization Technique for Radiation Therapy Planning
… paradigm, we have applied it to Gamma Knife radiosurgery and High-Dose Rate Brachytherapy (HDR) for prostate cancer. Mathematically, Gamma Knife radiosurgery is a ball-packing process whose goal is to 'pack' some spherical high dose volumes into a tumor volume, while brachytherapy is to find …
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End-to-end testing of the Leksell Gamma Knife Icon system
The Leksell Gamma Knife Icon is a stereotactic radiosurgery system that is used to non-invasively treat brain lesions. It incorporates 192 fixed cobalt-60 sources, which ensures the highest degree of accuracy during treatment due to the minimization of potential error from stationary sources. The …
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Commissioning An Anthropomorphic Spine and Lung Phantom For Remote Dose Verification of Institutions Participating In Rtog 0631
… consistent radiation administration in spinal radiosurgery clinical trials. This study assessed the phantom’s dosimetric and anatomic utility. The ‘spine phantom’ is a water filled thorax with anatomy encountered in spinal radiosurgery: target volume, vertebral column, spinal canal, esophagus, …
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Bioengineering-enhanced neurosurgical solutions
… of this vast discipline: neuro-oncology, radiosurgery and neuro-traumatology. After a thorough identification of some unresolved clinical problems and the limits of current management strategies in those areas, some technical solutions are proposed and defined from either experimental …
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A Complete Dosimetric Model of the Gamma Knife Perfexion Using Penelope Monte Carlo Codes
… the focus. Planning for Gamma Knife stereotactic radiosurgery (GK SRS) is performed using images from computed tomography (CT) and/or magnetic resonance (MR) imaging, as well as manual skull measurements. The manufacturer's software used to plan the delivery of these treatments uses a simplistic …
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HIGH FIELD MAGNETIC RESONANCE IMAGING-BASED GEL DOSIMETRY FOR SMALL RADIATION FIELDS
… modulated radiotherapy, and stereotactic radiosurgery, as well as for cellular and preclinical radiobiology studies (very small fields, <1 mm diameter). Radiation dose characteristics for these small fields are difficult to determine in multiple dimensions because of steep dose gradients …
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Monte Carlo simulation studies for spatially fractionated radiation therapy techniques
… the small penumbrae in comparison with existing radiosurgery techniques, suggest a potential gain in healthy tissue sparing in those new techniques.
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Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
… targeted treatments such as stereotactic radiosurgery or the vascular endothelial growth factor inhibitor bevacizumab. The main objective of this thesis was to investigate targeting of the receptor tyrosine kinase MERTK as a potential pharmacological intervention in schwannomas and …
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An optical computed tomography scanner for three dimensional gel dosimetry of radiotherapy dose distributions
… appeal. A specific application of stereotactic radiosurgery was targeted, where small dose distributions are delivered with high spatial accuracy to cranial tumours. Improvements in the practicality and efficiency of optical CT scanning were initially sought by elimination of the need for a …
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Development of a Comprehensive Linac-based Quality Assurance Program for a Retrofitted Micro-MLC SRS System
In Stereotactic Radiosurgery, one of the most import factors that must be measured is the accuracy of the localization system, whether it be lasers or camera system; and the coincidence of the localized isocenter to the radiation isocenter. According to TG-142 the minimum deviation between the …
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Characterization of Oslds For Use In Small Field Photon Beam Dosimetry
… mailable remote audit tool used for stereotactic radiosurgery (SRS) single beam dosimetry. A prototype phantom was designed and built housing nanoDot (Landauer Inc., Glenwood, IL) Al<sub>2</sub>O<sub>3</sub>:C optically stimulated luminescence dosimeters (OSLDs) whose visible active luminescent …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… to surgical lesion eradication or stereotactic radiosurgery. CCM affects up to 0.5% of the human population and can occur either in a sporadic or familial form. Loss-of-function mutations in any of three genes CCM1, CCM2 and CCM3 have been associated to familial CCM. Postnatal …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… and meningiomas are limited to surgery and radiosurgery, both carrying additional risks for the patient, new therapy approaches are desperately needed. Therefore, we explored if a schwannoma mouse model and cell culture and primary meningioma cells would be suitable systems to allow the …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… for this group of tumours are surgery and radiosurgery/radiotherapy. Hence, there is an urgent need for new effective drug-based treatments.<br/>TAM (TYRO3, AXL and MERTK) family receptors are involved in tumour development, progression, metastasis and resistance to targeted therapies in …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… chemotherapeutic agents leaving surgery and radiosurgery as the only remaining treatment options. Depending on their location, NF2-related tumours can cause a number of side effects, including nausea, balance problems, and in some cases hearing and/or vision loss. Phosphorylation is a key …
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