Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"radiosensitizing"”.
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
… the mechanisms by which the peptide exerts its radiosensitizing effects on CSCs. Specifically, my studies focused on investigating the effects of TP508 on DNA double-strand break repair mechanisms. Results showed that TP508 significantly sensitizes medulloblastoma CSCs to RT by inhibiting …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… DNA-targeting.</p> <p>Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation after intravenous administration, and …
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Interaction of the potential DNA-radiosensitizer 8-bromoadenine with free and plasmonically generated electrons
… sensitize the cancerous tissue to radiation. The radiosensitizing action of certain therapeutic agents can be at least partly assigned to their interaction with secondary low energy electrons (LEEs) that are generated along the track of the ionizing radiation. In the therapy of cancer DNA is an …
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Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
… radiotherapy administered with FDA approved, radiosensitizing chemotherapeutics for the treatment of metastatic prostate cancer. Taken together, BB2r targeted radiopharmaceuticals have the potential to fill a well known clinical need for the diagnosis and treatment of metastatic prostate …
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Monte Carlo simulations, in vitro and in vivo experimental verifications for preclinical studies
… micro-CT images. - The role of an innovative radiosensitizing molecule in Glioblastoma tumor protontherapy quantifying the variation in survival response and the dose modifying factor investigating also the gene expression modification induced during in vitro studies. In addition, the role of …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
… doxycyclin-induction of myc does not mimic the radiosensitizing effects of EB 1089. EB1089 increases radiation-induced reactive oxygen species (ROS) generation; however, both free radical scavengers, N-acetyl cysteine (NAC)and reduced glutathione (GSH), fail to attenuate the radio-sensitizing …
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Computational Modelling of Radiosensitising Properties of Nanoparticles
… treatment of cancerous tumors by acting as radiosensitizing agents which may potentially lead to a reduction of side-effects caused by radiotherapy. This theses presents a framework to accurately explore a number of important parameters of coated NPs using computational and theoretical …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… of noncytotoxic 5-FC to the cytotoxic and radiosensitizing drug 5-FU. Cytotoxic 5-FU and its toxic metabolites can readily diffuse unto surrounding tumor cells giving CD. HB1.F3 were transduced with retroviral vectors expressing the E.coli CD. Rats were implanted with U373MG, U251MG human …
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Dissecting the Role of microRNAs in the Radiation Response of Human Prostate Cancer
… models. Specifically, we found that miR-205 radiosensitizing effect was imputable to the downregulation of PKC-ε. Consistent with PKC-ε well-established role in DNA damage repair, we found that pEGFR and, consequently, pDNA-PK levels were significantly reduced by miR-205 reconstitution, thus …
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A Monte Carlo-based Model Of Gold Nanoparticle Radiosensitization
… therapeutic ratio can be achieved by utilizing radiosensitizing agents designed to enhance the effects of radiation at the tumour. Gold nanoparticles (AuNP) represent a novel radiosensitizer with unique and attractive properties. AuNPs enhance local photon interactions, thereby converting …
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The evaluation of targeted radionuclide therapies and radio sensitising agents in malignant melanoma
… cells such as melanin may in combination with radiosensitizing agents may improve the effectiveness of therapy towards the disease. Aims: The aims of this study were three-fold: • To assess the effectiveness of the melanin binding radionuclide [131I]MIP1145 in the treatment of malignant …
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The potential of the superoxide dismutase inhibitor, diethyldithiocarbamate as an adjuvant to radiotherapy
… approximately 4 hours, it was possible to show a radiosensitizing effect by means of a tumour growth delay assay. This time modulation effect of DOC was shown in larger tumours, rather than smaller tumours, which could indicate that tumour oxygenation is an important criterion in determining the …
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The role of c-FLIP in regulating resistance to ionizing radiation
… (NSCLC) cell lines to IR. Furthermore, the radiosensitizing properties of HDAC inhibitors were highly dependent on their ability to suppress FLIP expression.Therefore. FLIP down-regulation induced by HDAC inhibitors is a potential clinical strategy to radiosensitize and improve control of …
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Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… the blood-brain barrier and recapitulated its radiosensitizing effects in an intracranial GBM model. We found that NVP-BEZ235, administered with IR, can attenuate DSB repair in these intracranial tumors, attenuate tumor growth, and extend survival of tumor-bearing mice. Importantly, attenuation …
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Effekte von Hypericin auf humane renale Karzinomzellen in vitro
Das Gewöhnliche Johanniskraut (Hypericum perforatum L.) ist eine seit der Antike bekannte Heilpflanze. Einer seiner Inhaltsstoffe, das so genannte Hypericin, ist namensgebend für diese Pflanzengattung und wird in speziellen Drüsen auf Blütenblättern und Blättern produziert. Es dient der Pflanze als …