Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"radiosensitization"”.
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A Monte Carlo-based Model Of Gold Nanoparticle Radiosensitization
… damaging electrons. Experimental reports of AuNP radiosensitization reveal this enhancement effect to be highly sensitive to irradiation source energy, cell line, and AuNP size, concentration and intracellular localization. This thesis explored the physics and some of the underlying mechanisms …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
… inhibition of autophagy, suggesting selective radiosensitization against cancer cell lines. The current studies are consistent with the premise that while autophagy mediates a cytoprotective function in irradiated breast tumor cells, promotion of autophagy can also confer radiosensitivity by …
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Effects of Concurrent Radiosensitization and Chemoradiotherapy for Brain Tumors
… cancers employing nanoparticle mediated radiosensitization and chemoradiotherapy. Methods: We are using nanoparticle (NP) spectroscopy with a broad range of novel biocompatible nanoparticles including carbon quantum dots (CQD), graphene quantum dots (GQD), and CdSe/Zns quantum dots (QD) …
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
<p>Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for …
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Novel Functions of Cetuximab In Egfr-Targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
… we elucidated the mechanism of cetuximab in radiosensitization, and discovered novel functions of cetuximab in glycolysis inhibition and cellular redox status regulation. We found that cetuximab inhibits radiation-induced hypoxia inducible factor 1 (HIF-1), which is required for the …
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Nanoparticles for Simultaneous Assessment of Ros and Radiosensitization of Brain Cancer Cells for Improved Radiotherapy Outcomes
… are under intense research as a new frontier for radiosensitization of highly resistant cancerous tumour. Nanoparticle Mediated Dose Enhancement of Radiation Therapy is emerging as a favourable modality for enhancing radiotherapeutic ratio through local tumour dose enhancement and …
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Development of Gold-Magnetite Hybrid Nanoparticles for Advanced Radiotherapy
… theranostic nanotools for imaging-guided radiosensitization of cancers. H-NPs are designed to exert a dual function: (i) to provide contrast enhancement in magnetic resonance imaging (MRI).and (ii) to enhance radiation effects in the cancer. The imaging and the radiosensitization …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… The objective of this thesis is to advance radiosensitization of treatment-resistant densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.</p> <p>Clinical translation of radiosensitizing nanoparticles …
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Design of an Ytterbium-169 brachytherapy source for gold nanoparticle-aided radiation therapy
… specificity in nanoparticle form. The degree of radiosensitization is highly dependent on both the local gold nanoparticle concentration in the tumor and the radiation source type. Previous Monte Carlo simulations have demonstrated that the gamma-ray energy spectrum of Ytterbium-169 is a strong …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
… enhancement of striped gold nanoparticle induced radiosensitization causing membrane rupture and genomic damage.
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Enhancing Radiation Sensitivity In Non-Small Cell Lung Cancer
… therefore conferring resistance to the radiosensitization. In summary, my studies which focused on how these two specific targeted pathways caused radiation sensitization emphasized the need to better understand the molecular and signaling complexities in determining radiation …
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The synthesis and characterization of water soluble platinum (II) pophyrins and their potential as radiosensitizers
… Neither (3) nor (4)showed any signs of radiosensitization in hypoxic conditions at platinum(II) porphyrin concentrations of 100^. (1) Platinum-5,15-bis(4-nitropheny1)-10,20-bis(4-methylpyridinium)porphyrin R1=R3=^NO2 R2 = R4 =-0-€3-1CH3 (2) …
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Porphyrin chemistry pertaining to the design of anticancer agents
… which are presumed to improve the properties of radiosensitization (NO2), DNA association (NH2, pyridyl), and water-solubility (methylpyridinium and sulfonatophenyl) are introduced into the porphyrin structures. The Ili NMR spectra of these porphyrins are presented with each of the signals …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
… to determine the future potential for UCP2 radiosensitization with other radiation modalities. These studies reveal that while UCP2 is not a target for mitochondrial dynamics, it is a promising radiosensitizer for PDAC and it is conceivable to extend this to other radiation modalities. This …
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Polymer- and Bioadditives-Assisted Synthesis and Surface Modification of Anisotropic Gold Nanocrystals
… potential biomedical applications such as radiosensitization and photothermal therapy of cancer.
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Investigating couplet strategies incorporating 4 pillars of cancer therapy
… and current literature regarding target-based radiosensitization strategies. Here we also present some of the clinical presentations of companion animal cancers that are commonly treated with radiotherapy and highlight the utility of companion animal models for improving the predictive value of …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… we investigate a molecular mechanism of radiosensitization that couples ionizing radiation to inhibition of translocation-driven sarcomagenesis in myxoid liposarcoma. We performed co-immunoprecipitation (co-IP) to identify proteins interacting with FUS-CHOP. Incucyte assays measured cell …
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Induced Cytotoxicity In Crebbp/Ep300Mut Head and Neck Squamous Cell Carcinoma
… of <em>CREBBP/EP300</em> is inhibited. This radiosensitization manifests in the form of increased cell death for <em>CREBBP/EP300</em>mut HNSCC treated with XRT. This project looks at the effect of two chemotherapeutic agents: cisplatin (CDDP) and doxorubicin (DOX) and the response that …
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Nanoparticles For Biomedical Applications
… by the fullerene backbone, dampening the radiosensitization effect.</p> <p>In the final part of this thesis, we take the backbone of our previously designed molecule, a biocompatible C<sub>60</sub> fullerene, and derivatize it with serinol only to make it both extremely water soluble and …
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Nanopartículas y radioterapia: estudio del posible efecto radiosensibilizador de puntos de carbono dopados con iones de Gadolinio en células derivadas de Glioblastoma (U87)
El glioblastoma es uno de los tumores más agresivos y de difícil tratamiento, debido a su ubicación, su morfología y su comportamiento radioresistente. Al estar ubicado en el cerebro, no es posible extirparlo completamente durante el procedimiento quirúrgico, por lo cual, en la mayoría de los casos …
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