Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"radiosensitivity"”.
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Analysis of radiosensitivity in South African cervical and breast cancer patients
… repair mechanisms display increased chromosomal radiosensitivity. The G0-micronucleus assay (MN assay) and the γ-H2AX assay are two assays used in radiobiology to study DNA DSB and repair. Breast cancer is the leading cancer amongst South African women, with a lifetime risk of 1 in 34. Since most …
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In Vitro Chromosomal Radiosensitivity and Cell Cycle Progression in Cancer Survivors
The in vitro 02 chromosomal radiosensitivity assay is a technique used to investigate variation in the cellular response to radiation. In brief, lymphocytes are irradiated in the 02 phase of the cell cycle to induce DNA damage, which is exhibited at the subsequent metaphase as chromatid gaps and …
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A Comparison of Two 'In Vitro' Assays to Assess Radiosensitivity in Patients Receiving Radiotherapy
… radiotherapy and the need for predictive radiosensitivity testing. Patients who display unusual sensitivity to radiation may also exhibit a poor DNA repair capacity. Consequently, in vitro assays which assess radiation-induced DNA damage and its subsequent repair may have potential in …
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The Importance of Dna Repair Capacity to (And A Model to Predict) Cell Radiosensitivity to Ions
… a number of biological factors known to affect radiosensitivity to photons, including DNA repair capacity. Thus, it is expected that an additional benefit of using ions is that they mitigate the great heterogeneities in treatment responses commonly observed in photon therapies.</p> <p>However, …
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Bystander Effects Due To Neutrons, And Low-Dose Hyper-Radiosensitivity To Gamma Rays In Human Cells Using Cytogenetics
… low dose exposures. However, the low-dose hyper-radiosensitivity (HRS) phenomenon, in which cells are especially sensitive at low doses but then show increased radioresistance at higher doses, provides evidence of nonlinearity in the low dose region. HRS is more prominent in the G2 phase of the …
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Cytogenetic Evaluation Of Low Dose Hyper-Radiosensitivity In Human Lymphoblastoid Cell Lines Exposed To Cobalt-60 Gamma Radiation.
… in G2 at doses below 30 cGy, show hyper-radiosensitivity (HRS) as measured by reduced clonogenic cell survival, thereby indicating greater cell lethality than is predicted by extrapolation from high-dose responses. We therefore hypothesized that the cytogenetic response in G2 cells to low …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
… after radiation alone. 1,25D3 also enhanced radiosensitivity and promoted autophagy in MCF7 cells that overexpress Her-2/neu as well as in p53 mutant Hs578t breast tumor cells. In contrast, 1,25D3 failed to alter radiosensitivity or promote autophagy in the BT474 breast tumor cell line with …
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Examination of molecular genetic factors involved in sensitivity to breast cancer following radiation exposure
… and defects in repair systems can result in radiosensitivity. Because radiation exposure, DNA repair deficiency and telomere malfunction are associated with cancer risk, we investigated Lymphoblastoid Cell Lines (LCLs) from breast cancer patients and controls for chromosomal radiosensitivity, …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… the effects of these substances on cellular radiosensitivity and repair. Repair was assessed by means of a split radiation dose experiment. The design of such an experiment required that cells be exposed to inhibitory test media for different times between two fractions of radiation. Any …
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The Impact of Radiation on Glioblastoma Evolution
… of intratumoral heterogeneity (ITH) on intrinsic radiosensitivity, by determining the effects of radiation on glioma stem-like cell (GSC) initiated orthotopic xenografts, and by assessing radioresistance with a reirradiation protocol. To determine the impact of ITH on intrinsic radiosensitivity, …
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Activation of the p53 pathway in combination with photon irradiation for the treatment of neurological tumour cells
… the aim of assessing whether AMG232 enhances radiosensitivity in a TP53-dependent manner. Cell proliferation, cell-cycle distribution, and DNA damage were assessed using growth assays, flow cytometry, and H2AX foci analysis, respectively. The findings showed that TP53 status strongly …
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Mitochondrial dynamics in the radiation response of cancer cells
… cancer cell mitochondrial features and inherent radiosensitivity, and to determine the effect of modulation of mitochondrial dynamics on radiation response using a fission inhibitor, Mdivi-1. Methods: Mitochondrial status in a number of cancer cell lines was characterised by assessment of …
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Modeling and computer simulation of tumor growth and tumor response to radiotherapy
… such as cell cycle time, growth fraction and radiosensitivity.
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ANALYSIS OF B LYMPHOCYTES IN MOUSE MODEL LIGASE IV WITH HYPOMORPHIC MUTATION IN VDJ RECOMBINATION ASSOCIATED WITH GROWTH DEFECT
… cell leukemia associated with increased cellular radiosensitivity. The clinical presentation of the syndrome is complex and heterogeneous and may include varying degrees of lymphopenia, growth retardation and microcephaly. The phenotypic effects of the impaired repair of non programmed DNA damage …
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Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer
… as antigen concentration, void fraction, and the radiosensitivity parameter a, as well as on targeting agent molecular parameters such as the diffusivity and antigen-binding association rate.
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
… for the esophagus, but inherent patient radiosensitivity is not considered, leading to suboptimal treatment regimens.</p> <p>The purpose of this work was to investigate radiation injury in the esophagus by first developing <em>in-vivo</em> imaging biomarkers of radiation-response in the …
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Challenging the Rigor of Alpha/Beta and Relative Biological Effectiveness in Tumor Contorl [sic] Probability Determinations via In Silico Modeling That Incorporates Individualized Biological and Physiological Data
… biological information such as intrinsic radiosensitivity, hypoxia, tumor repopulation after irradiation, number of cells per tumor, and physiological information such as whether a tumor undergoes reoxygenation between fractions. TCP curves represent model output and both the LQ and RCR …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… metastasis. However, the mechanism for its radiosensitivity is unknown. In order to further understand the biological mechanisms underlying MLPS response to radiotherapy we studied the fusion oncoprotein FUS-CHOP and linked its role in sarcomagenesis to the radiosensitivity …
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Enhancing the radio sensitivity of prostate cancer using RALA Gold nano-complexes
… to enhance AuNP cell internalisation and in turn radiosensitivity of PCa. RALA-AuNP have undergone extensive characterisation following synthesis, proving optimal for in vitro and in vivo application. Significant improvements in cell uptake and localisation of AuNP have been presented. At the time …
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The Effects of the Deposition of Radioactive Strontium ( Sr85 + Sr89 ) on the Aorta of the Rat
The high in vitro radiosensitivity of the mucopolysaccharide matrix of connective tissue was demonstrated by Brinkman and Lamberts in 1961 in experiments involving changes in membrane permeability. Their data revealed that the permeability of a relatively crude, multilayered preparation of …
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