Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"radionuclide therapy"”.
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Predictive modelling of external dose rate from radionuclide therapy patients following discharge from hospital
Background: Di erentiated thyroid carcinoma patients undergo thyroidectomy, followed by radiodine ablation in hypothyroid or euthyroid state. Several attempts were made to predict the external dose rate, however, there is a lack of accuracy in predictions from existing models of dose rate decay. …
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The evaluation of targeted radionuclide therapies and radio sensitising agents in malignant melanoma
… by inadequate dose delivery of conventional radiotherapy options. A targeted approach to radiotherapy exploiting native features of the melanoma cells such as melanin may in combination with radiosensitizing agents may improve the effectiveness of therapy towards the disease. Aims: The aims of …
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Microdosimetry of radiohalogens in thyroid models
… studies important for dose-planning before radionuclide therapy. 211At, with its relatively long half-life, stable daughter nuclide, and production and labelling possibilities is considered as one of the most attractive alpha particle emitters in radionuclide therapy. With growing use of …
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A comparison of three gadolinium based approaches to cancer therapy
Some recent neutron capture therapy (NCT) research has focused on using compounds containing the element gadolinium (Gd), which produces internal conversion and Auger cascade electrons upon absorbing thermal neutrons. The low energy, nanometer-range, Auger electrons are absorbed locally and …
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Production and separation of medically relevant terbium-161 for radiopharmaceutical applications and recycling of target materials
… (161Tb) is crucial for advancing targeted radionuclide therapy applications in nuclear medicine. Here, we present two approaches for the production and purification of 161Tb using high-flux neutron irradiation and multi-step chromatographic separation. Enriched [160Gd]Gd(NO3)3 and …
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Novel Amino Acid Transporter-Targeted Radiotracers For Breast Cancer Imaging
… modalities for tumor diagnosis, or for internal radionuclide therapy in future.</p> <p>Based on the <em>in vitro</em> and <em>in vivo</em> evaluation using the rat mammary tumor models, <sup>99m</sup>Tc-EC-AMT is considered as the most suitable radiotracer for breast cancer imaging overall, …
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Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. 211At is proposed for radionuclide therapy and preclinical and clinical research …
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Fast Monte Carlo Simulation of ⁹⁰Y Bremsstrahlung using a Kernel-based Photon Source
In targeted radionuclide therapy using ⁹⁰Y, bremsstrahlung photons can be used for imaging and subsequently for absorbed dose estimation. Monte Carlo simulation is a reliable method to study bremsstrahlung imaging but it takes a long computation time as not all ⁹⁰Y disintegrations result in …
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A BIOMARKER ENRICHMENT PHASE II TRIAL OF 177LU-DOTATATE IN METASTATIC NASOPHARYNGEAL CANCER WITH A SAFETY RUN-IN
Nasopharyngeal cancer (NPC) is endemic in Southeast Asia. There is a lack of effective targeted treatments for NPC. In this thesis, we investigate the prevalence and prognostic significance of somatostatin receptor 2 (SSTR2) expression in an international study comprising multiple clinical cohorts …
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Investigating a novel combination treatment of androgen deprivation therapy, pelvic external beam radiotherapy and radium-223 dichloride in the management of hormone sensitive prostate cancer metastatic to bone
… of treatment consists of androgen deprivation therapy (ADT).Recently a number of treatments added to ADT have been shown to extend survivalin these patients including docetaxel and abiraterone as well as external beamradiotherapy (EBRT) to prostate (in low volume disease). We wished to test …
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Application of radioisotope imaging and therapy in patients with breast carcinomas that express the sodium iodide symporter gene
… trap iodine. Radioiodide scintigraphy and therapy are based on the uptake of radioiodide by NIS in thyroid tissue, which can concentrate all isotopes of iodine. Breast cancer is the most common type of cancer in women in the UK, and is the second most common cause of cancer-related death in …
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Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
… for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. Tumour response is variable and renal and haematological …