Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"radioligands"”.
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
… work sought to characterize novel and existing radioligands, assessing their utility and effectiveness for positron emission tomography (PET) imaging of neurodegeneration. Three proteins were targeted: 1) colony stimulating factor-1 receptor (CSF-1R); 2) glycogen synthase kinase-3 (GSK-3); and …
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Evaluation of PBR in Breast Cancer
… measuring altered cellular metabolism. Specific radioligands are being developed to allow non-invasive analysis of protein expression to further characterize tumors. One protein that has been identified as a promising target is the Peripheral Benzodiazepine Receptor: PBR). PBR expression is …
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Kappa Opioid Binding Characteristics in Rat Central Nervous System Homogenates (Binding)
… subtypes and the availability of specific radioligands.
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… neuroimaging. In this thesis, new SPECT or PET radioligands directed towards two different brain elements, being the monoamine system and the P-gp transporter, were developed and evaluated in vivo. The first objective of this thesis was the design of radiotracers for the monoamine system more …
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Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
… using positron emission tomography (PET) radioligands to visualise and quantify different aspects of pathophysiology in vivo. [18F]AV-1451tau was introduced primarily to study tau pathology in Alzheimer’s disease using, which differs from FTD tauopathy in several respects. I examined the …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… C1-click-F, two potential FPR2-targeting PET radioligands identified through collaboration with Imperial College London. Radiotracer [11C]Quin C1 was produced with decay-corrected radiochemical yield (d.c.RCY) (decay corrected to the start of synthesis) of 12% (n = 1) at the end of synthesis …
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The Structural Requirements of Gastrin and Glycine-Extended Gastrin for Binding to Receptors from Normal and Cancerous Human Tissues
… emphasize the importance of using appropriate radioligands and experimental conditions for detection of receptors at both ends of the affinity spectrum.
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Design, Synthesis, Biological Evaluation and Metabolic Stability Studies of Sigma Receptor Ligands
Sigma receptors represent a unique family of proteins that includes two subtypes: sigma-1 and sigma-2. Sigma-1 receptors have been implicated in the behavioral and motivational effects of psychostimulants as well as in the pathophysiology of depression and Alzheimer's disease. Sigma-2 receptors are …