Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"radiolabeling"”.
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Development of New Radiolabeling Methods and Insights on Ionizing Radiation Interactions with Nanoparticles
… is two-fold. The first aim is development of new radiolabeling methods for various nanoparticles that allow stable attachment of a variety of imaging and therapeutic radionuclides. The second portion more fully describes mechanisms of interaction between ionizing radiation and nanoparticles.</p> …
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DNA detection system of homo-oligomers by electrochemical impedence measurements and quantification through radiolabeling
… and hybridized single stranded DNA through radiolabeling.
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Synthesis, Radiolabeling and Evaluation of a suite of Tracers with <sup>44</sup>Sc for Detecting Extracellular DNA
… <sup>44</sup>Sc. We describe the synthesis and radiolabeling of several NET probes and their in vivo pharmacokinetics.</p>
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Development of Methods for the Study of Phosphoproteins
… of phosphorylation sites-is mostly done with radiolabeling and proteomic techniques. Three main topics related to phosphoprotein characterization are included in this dissertation. First, large-scale characterization of the CHO (Chinese hamster ovary) cell phosphoproteome was done using two …
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I. Facile preparation of ortho-fluorophenols from non-aromatic precursors and investigation of applications to fluorine-18 labeling II. Resin-supported silyl ester precursors for kit-like radiolabeling with fluorine-18
… and 3) purest mode of decay. However, F-18 radiolabeling method is still underdeveloped, and thus, practical radiosyntheses are limited to nucleophilic substitution, especially at alkyl positions. Therefore, to extend the utility of F-18 for PET radiotracers, novel radiolabeling methods with …
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Biosynthesis and Characterization of Early Glycosylphosphatidylinositol Anchor Intermediates in Saccharomyces Cerevisiae
… intermediate that can be detected in in vivo radiolabeling experiments. I isolated this lipid and had it analyzed by liquid chromatography - mass spectroscopy (LC-MS) with an electrospray interface. The results show that this intermediate has very long chain fatty acids, most likely on its …
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Design, Synthesis And Characterization Of Lipidated Pna-Peptide Conjugates As Potentialtherapeutic And Diagnostic Reagents
… in vivo as a potential PET imaging reagent after radiolabeling with bromine-76.
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Comparison of Two Separation Methods for Biological Particles: Field-Flow Fractionation (FFF) and Sucrose Density Gradients
… for their biochemical composition (using radiolabeling and subsequent biochemical fractionation) revealing significant differences in the bulk biochemical makeup between prokaryotic and eukaryotic microbes. Even within domains, the sucrose gradient method was able to separate prokaryotic …
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Bioaccumulation of Triclocarban, Triclosan, and Methyl-triclosan in a North Texas Wastewater Treatment Plant Receiving Stream and Effects of Triclosan on Algal Lipid Synthesis.
… in this study by using [2-14C]acetate radiolabeling procedures. Preliminary results indicate high TCS concentrations are toxic to lipid biosynthesis and reduce [2-14C]acetate incorporation into total lipids. These results have led to the concern that chronic exposure of algae in …
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Efeito de preparações de produtos naturais (cravo da índia e tomate) e de um produto sintético na marcação de constituintes sangüineos com tecnécio-99m e na morfologia de hemácias isoladas de sangue de ratos wistar
… IF-P, although this extract did not modify the radiolabeling on BC, neither the radioactivity fixation on IFBC. The results indicate that these chemical compounds would have oxidative/chelating actions
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Characterization of Anodic Fuel Cell Catalysts Utilizing Various Surface Sensitive Techniques
… of methanol oxidation on the Pt/Pd catalyst. Radiolabeling with electrochemistry was used to examine the poison/potential and poison/environment relationships. Poison from methanol and formic acid was determined to be strongly adsorbed CO, which was replaceable by CO passed through the …
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Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease
… for amyloid imaging in terms of half-life and radiolabeling strategy. To obtain molecules that could be employed as 64Cu PET imaging agents and maintain affinity for Aβ species, our synthetic strategy is to covalently link 2-phenylbenzothiazole moiety, which has appreciable Aβ binding affinity …
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Production and separation of medically relevant terbium-161 for radiopharmaceutical applications and recycling of target materials
… chromatography method demonstrated superior radiolabeling performance, achieving maximum apparent molar activities of 1300 µCi/nmol for DOTA at 3.5 µCi/µL concentration, reaching up to 143,000 µCi/nmol at higher activity concentrations, and 200-400 µCi/nmol for DOTA-TATE at 7 µCi/µL …
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Tending towards Non-fouling: A study of the interaction between proteins and surfaces prepared by radio frequency glow-discharge plasma
… explores and describes new protocols involving radiolabeling protein studies, radioimmunoassay and substrate-based direct ELISA to better understand the adsorption, retention and changes in biological activity of the protein once it comes in contact with a biomaterial surface, which further …
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Supramolecular Structure-Enabled Delivery of Porphyrin to Glioblastomas Beyond the Blood-Brain Barrier
… by developing and applying a new microbubble radiolabeling strategy. Multimodal (ultrasound, PET, γ-counting and fluorescence) microbubble dissolution, shell blood clearance and biodistribution profiles were obtained ± FUS, yielding structure-activity relationships between pMB lipid …
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Discovery of Enzymes Responsible for an Alternate Mevalonate Pathway in Haloferax volcanii
… membranes of bacteria or eukaryotes. Radiolabeling experiments with acetate and mevalonate strongly implicate the mevalonate pathway in providing the isoprenoids for archaeal lipid biosynthesis. However, the enzymes responsible for mevalonate metabolism in archaea have remained either …
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Modulation of Endothelial Cell Adhesion to Synthetic Vascular Grafts Using Biotinylated Fibronectin in a Dual Ligand Protein System
… (XPS), atomic force microscopy (AFM), and 125I radiolabeling. The first modification to the DL system involved direct biotinylation of fibronectin (bFN) as a replacement for co-adsorption of FN with biotinylated bovine serum albumin (bBSA). This was analyzed with a Langmuir model using surface …
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
… with 18F for in vivo PET imaging studies. Before radiolabeling chemistry, the biological activity of each fluorinated cannabinoid towards CB1R was assessed in cell models (and in some cases rodents) successfully identifying several promising ligands that represent PET tracer candidates. The …
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Selenotrisulfide Derivative Of Alpha-lipoic Acid: Evaluation In A Cell Culture Model For Potential Use As A Topical Antioxidant
… utilization for selenoprotein synthesis through radiolabeling studies (75Se) in a human keratinocyte cell line (HaCaT). We have determined that is incorporated into selenoproteins with nearly the same efficiency as selenite and L-selenocysteine. We have also determined that LASe is far more …
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Characterization of an operon containing a ribosomal protein gene and lipid biosynthetic genes in Escherichia coli K-12
… Each ORF encoded a protein, as demonstrated by radiolabeling in maxicells. ORF1 (orfY) encodes a protein of unknown function. ORF2 and ORF3 (rpmF) were sequenced prior to this study and encode a protein called G30k of unknown function and L32, a protein of the large ribosomal subunit, …
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