Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"radioimmunoconjugates"”.
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
<p>Antibodies have long played a vital role in nuclear medicine for both the diagnosis and therapy of various malignancies. The role and development of antibodies in nuclear medicine can be broadly separated into three different categories: 1) bioconjugation strategies, 2) immunoPET imaging, and 3) …
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Radioimmunotherapy of Metastatic Disease - Studies of Alpha- and Beta-particle-Emitting Radionuclides in a Preclinical Model
… or 211At-mAbs. The intratumoral distribution of radioimmunoconjugates was examined over time using digital autoradiography and was related to tumor histology. The results show that the tumor response was dose dependent after treatment with 177Lu-mAbs alone. Both evaluated activities of 211At-mAbs …
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Biodistribution Studies of 64Cu-DOTA-Cetuximab after Intraperitoneal and Intravenous Injection in a Malignant Ascites Mouse Model of Human Gastric Carcinoma
… to tumor targeting and half-life prolongation of radioimmunoconjugates in the peritoneal cavity.
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… to cancer cells. Site-specifically modified radioimmunoconjugates exhibit superior <em>in vitro</em> and <em>in vivo</em> behavior compared to analogues synthesized <em>via</em> traditional stochastic methods. However, the development of approaches to site-specific bioconjugation that combine …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… thesis aimed to develop more potent trastuzumab radioimmunoconjugates (RICs) and novel trastuzumab/pertuzumab antibody-drug radioconjugates (ADRs) radiolabeled with beta and alpha particles, against HER2-positive BC. These agents were evaluated as potential theranostics for SPECT/PET imaging and …