Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"radio sensitization"”.
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Development of Natural Cyclic Peptide Inhibitors of XRCC4/XLF Interaction for Radio-Sensitization of Breast Tumor Cells
… and these peptides will inhibit NHEJ and thereby radiosensitize breast tumor cells. We have synthesized five DNA libraries that produced mRNA-peptide fusions containing a trillion unique peptide sequences that will be used for the selection of peptide inhibitors of the XRCC4/XLF interaction, and …
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop combination therapy to improve clinical outcome. The mechanisms between …
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Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… crucial to understand the mechanisms underlying radio- and chemo-resistance. We find that protracted TMZ treatment of mice bearing orthotopic tumors (generated by xenografting GBM9 neurospheres) leads to acquired-TMZ resistance resulting in tumor recurrence. In order to understand the basis for …
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Enhancing Radiation Sensitivity In Non-Small Cell Lung Cancer
… for lung cancer, the disease outcome after radiotherapy is still far from satisfactory despite ongoing advances in radiation techniques. Enhancing the radiosensitivity of lung cancer has the potential to improve the disease outcome of radiation treatments. Using a novel high throughput …
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Porphyrin chemistry pertaining to the design of anticancer agents
A limitation of radiotherapy is the lack of selectivity (in term of cell killing) toward tumor cells, especially toward hypoxic tumor cells. Porphyrin drugs used in photodynatnic therapy (PDT) have good selectivity (in term of drug accumulation) toward tumors, but the therapy has a limitation due …