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Showing 1 to 6 of 6 for “"radiation-induced lung injury"”.
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Ensemble Support Vector Machine Models of Radiation-Induced Lung Injury Risk
Patients undergoing radiation therapy can develop a potentially fatal inflammation of the lungs known as radiation pneumonitis: RP). In practice, modeling RP factors is difficult because existing data are under-sampled and imbalanced. Support vector machines: SVMs), a class of statistical learning …
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A Preclinical Study of Radiation-Induced Lung to xicity When Irradiating In A Strong Magnetic Field
… transverse magnetic field on the severity of radiation-induced lung damage in mice. This data can be used to support the safe clinical implementation of MRI-guided radiation therapy systems.</p> <p>Monte Carlo simulations and EBT3 film measurements were used to determine an irradiator and …
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Mechanisms Regulating Pulmonary Sensitivity to Radiation
… or treating pneumonitis/fibrosis following acute radiation exposure. Since it is neither ethical nor feasible to evaluate potential MCMs against radiation injury in the clinical setting, the FDA permits MCM licensure under an alternative drug development pathway ("Animal Efficacy Rule") that …
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Quantification of Pulmonary Ventilation using Hyperpolarized 3He Magnetic Resonance Imaging
Smoking-related lung diseases including chronic obstructive pulmonary disease (COPD) and lung cancer are projected to have claimed the lives of more than 30,000 Canadians in 2010. The poor prognosis and lack of new treatment options for lung diseases associated with smoking are largely due to the …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
<p>Radiation-induced lung injury (RILI) is caused by an early inflammatory process triggered by damage to lung parenchyma, epithelial cells, vascular endothelial cells and stroma. Initially, oxidative injuries after radiation induce altered expression of pro-inflammatory cytokines. Infiltrating …
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Dynamics and utility of cell-free DNA release following radiotherapy in prostate cancer and non-small cell lung cancer
… undergoing radiotherapy for prostate and lung cancer; samples from a sub-cohort underwent methylation analysis and NGS. METHODS: Analysis of blood plasma cfDNA was carried out on samples from patients receiving stereotactic ablative body radiotherapy for non-small cell lung cancer (n=39), …