Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 342 for “"radiation therapy"”.
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Improving Cervical Cancer Nodal Boost Radiation Therapy By Quantifying Uncertainties and Exploring Advanced Radiation Therapy Modalities
<p>Radiation therapy for patients with intact cervical cancer is frequently delivered using primary external beam radiation therapy (EBRT) followed by two fractions of intracavitary brachytherapy (ICBT). Although the tumor is the primary radiation target, controlling microscopic disease in the …
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Adaptive Radiation Therapy Of Prostate Cancer
… calculated to evaluate reaction of rectum to radiation. Rectal EUD increased 5-7% in the real delivery of the plan with 10/5 mm margin for all five patients. As the margin was reduced, the percent difference increased to 5-14%. Margin reduction from 10/6 mm to 5/3 mm was a very effective way …
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Temporally Feathered Radiation Therapy under Uncertainty
This thesis focuses on radiation therapy planning through novel stochastic optimization models that account for biological heterogeneity and uncertainty in organ-at-risk (OAR) responses. Building on the temporally feathered radiation therapy (TFRT) strategy, we develop a personalized, biologically …
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Optimization under uncertainty in radiation therapy
… robust approaches to managing uncertainty in radiation therapy treatments for cancer. In the first part of the thesis, we study the effect of breathing motion uncertainty on intensity-modulated radiation therapy treatments of a lung tumor. We construct a robust framework that generalizes …
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Intelligent Automatic Treatment Planning for Radiation Therapy
Radiation therapy (RT) utilizes high-energy radiation to disrupt the DNA of cancer cells, impeding their repair and division, ultimately causing cancer cell death. The goal of RT is to spare radiation dose to healthy cells while maintaining the dose to cancer cells. Modern RT employs advanced …
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Electrical impedance tomography for internal radiation therapy
Internal radiation therapy is a radiation-based treatment for various forms of localized cancer. In this treatment, several needles or catheters are inserted percutaneously into the tissue, and radiation is delivered through them directly to the site of the tumour growth. Imaging methods to …
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New Optimization Technique for Radiation Therapy Planning
<p>The main goal of radiation therapy is to deliver a lethal dose of radiation to the targeted tumor while minimizing the radiation dose to the surrounding normal tissues and critical organs. Modern cancer therapy has benefited enormously from computer controlled treatment devices with increased …
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Attitudes towards a career in radiation therapy
… radiologic technologists and twenty-four radiation therapy technologists employed in six health care facilities (hospitals and a cancer center) in the Dallas-Fort Worth metroplex participated in a study to determine if there existed a difference in the two groups' attitude toward a career …
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Improving Dose Calculations In Electron-beam Radiation Therapy
… in tissue makes electron beams a useful radiation treatment modality for many tumour sites. However, the simplistic methods of dose calculation in current clinical use lack sufficient accuracy in many situations of clinical importance. This thesis rests on the premise that a more accurate …
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Auto-Segmentation In Pancreatic and Liver Radiation Therapy
… regimens, such as stereotactic body radiation therapy (SBRT), are emerging as an important pillar of the management of liver and pancreatic cancer. The success of these treatment modalities hinges upon the precise and standardized segmentation of organs-at-risk and target volumes to …
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Dynamic optimization of fractionation schedules in radiation therapy
… optimizing the fractionation scheme in radiation therapy. In the first part of the thesis, we consider delivering a different dose each day depending on the observed patient anatomy. Given that a fixed prescribed dose must be delivered to the tumor over the course of the treatment, such …
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Insights into the radiation Chemistry of FLASH Radiation Therapy
<p><strong>Purpose:</strong> FLASH radiation therapy (FLASH-RT) is an emerging modality that delivers radiation at ultra-high dose rates (UHDR) and has shown consistent normal tissue sparing while preserving tumor control compared to conventional RT—a phenomenon termed the FLASH effect. Despite …
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Burnout In Radiation Therapy: Examining The Six Leading Influences
… of burnout amongst healthcare workers, including radiation therapists. Since burnout is associated with an increase in medical errors (Sanchez-Reilly, 2013), it affects both the well-being of the patient and patient satisfaction scores, which are important to a hospital’s reputation. Burnout has a …
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Uncertainty Medicine: The Development of Radiation Therapy, 1895-1925
… overview of the development of x-ray and radium therapy in both the United States and Great Britain in the period from 1896 to 1925. Specific attention is paid to the early work of pioneering radiation therapists, many of whom had not completed a traditional medical education, and to debates …
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Positron Emission Tomography Phantom Studies for Radiation Therapy Target Delineation
Bioanatomic imaging is becoming more prevalent in radiation treatment planning (RTP). Positron Emission Tomography (PET) is one form of bioanatomic imaging that is readily used for RTP of non-small-cell lung cancer (NSCLC) and head and neck cancer (H&N). PET utilizes a radiotracer, such as …
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Educating newly diagnosed cancer patients who are undergoing radiation therapy
… and to improve their understanding of the radiation treatment process through the presentation of an educational video (Bogdan & Biklen, 2007). Patients often remained confused and thereby missed vital information, regardless of how many explanations or how much information they had been …
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Polymer Gel Dosimetry in Magnetic Resonance-Image Guided Radiation Therapy
… of a magnetic resonance (MR) scanner with a radiation therapy treatment unit allows for adaptive radiotherapy guided by MR imaging (MR-IGRT) and has been proposed as an advanced radiotherapy treatment modality. The delineation of the tumor and adjacent organs is greatly improved by the soft …
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Monte Carlo simulation studies for spatially fractionated radiation therapy techniques
… the possible gain in tissue sparing in hadrontherapy when a spatial fractionation of the dose is used. Monte Carlo simulations (GATE v.6) have been used as a method to assess the dose distributions in a cylindrical water phantom (16 cm height and 16 cm of diameter). The phantom was irradiated …
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Automating Intensity Modulated Radiation Therapy Treatment Planning by using Hierarchical Optimization
<p>The intensity modulated radiation therapy (IMRT) optimizes the beam’s intensity to deliver the prescribed dose to the target while minimizing the radiation exposure to normal structures. The IMRT optimization is a complex optimization problem because of the multiple conflicting objectives in it. …
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Moving Phantom Study of Stereotactic Body Radiation Therapy for Lung Cancer
… assess the accuracy of current stereotactic body radiation therapy (SBRT) lung treatment methodologies, we performed a systematic evaluation using phantoms that simulated motions from real patients (irregular motions) as well as sinusoidal motions (regular motions). The irregular patterns …
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