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Showing 1 to 20 of 36 for “"radiation response"”.
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Ceramic interfaces and their radiation response
… extreme environments such as one that contains radiation, the physics and the material science of how the ceramic materials change still need to be clarified. In this present examination, the behavior of ceramic materials was studied under a variety of irradiation conditions. One aspect of …
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Low Dose Dosimetry and Radiation Response in Rodent Models
Exposure to ionizing radiation from diagnostic imaging procedures has dramatically increased in the last three decades. Computed tomography is a powerful and invaluable diagnostic imaging tool, but it is essential that the radiation risks be appropriately quantified so that clinicians are in the …
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The Role of Inflammation in the Early Radiation Response
<p>Radiation is one of the principal treatments for adults and children with brain tumors, and is one of the oldest established treatments for tumors of all types. Currently, the limiting factor for the use of radiation is the effect on normal tissue adjacent to the tumor. Toxicity, including early …
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Mitochondrial dynamics in the radiation response of cancer cells
… of key cellular processes that determine the response of cells to damage. Mitochondrial fission and fusion are associated with cell cycle regulation, apoptosis, cellular bioenergetics and redox status, which contribute to cellular homeostasis and damage response. The study aimed to describe …
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Far-infrared radiation response of antenna-coupled quantum-effect devices
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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The role of RNAs and extracellular vesicles in the radiation response
… have not been directly traversed by ionizing radiation exhibit DNA damage effects as though they had been. It is established that signalling molecules such as cytokines and reactive oxygen species (ROS) signal to surrounding cells to mediate BE, however more recently it has been demonstrated …
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Structural Analysis and Radiation Response of Multi-Walled Boron Nitride Nanotubes
Electron irradiation damage analysis has revealed that: (1) Damage mechanism is different from carbon nanotubes; no radiation induced amorphization was observed, (2) irradiation response of BN nanotubes to 200 keV electrons in TEM environment is almost independent of temperature, (3) under intense …
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Characterizing in vitro propagation and radiation response of murine mammary stem cells
… be sensitive to known carcinogens (i.e. ionizing radiation), which impact their susceptibility to transformation. The involvement of mammary stem cells in tumorigenesis could explain the heterogeneity and molecular complexity of breast cancer. However, the involvement and the underlying mechanisms …
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Role of Cell Death Regulatory Genes and Radiation Response in Pancreatic Adenocarcinomas
… caused enhanced sensitivity of cell lines to radiation. The restoration of RH function by FrI was linked to down-modulation of DNA methyltransferase enzyme that is often implicated in hypermethylation of promoters. Over-expression of RII in pancreatic tumour cells led to the restoration of …
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Dissecting the Role of microRNAs in the Radiation Response of Human Prostate Cancer
… miRNAs likely to be involved in influencing PCa radiation response, we first performed miRNA profiling analysis of PCa cell lines exposed to photon irradiation. Based on their modulation upon radiation exposure, and their role in regulating pathways associated with radiation response we …
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Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
… The overall goal of this work is to improve response to conventional cancer therapies by targeting tumor hypoxia. This has been carried out and evaluated through the use of polymersome-encapsulated myoglobin (PEMs) with the hypothesis that O2-releasing PEMs will increase tumor oxygenation, …
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Some Characteristics of Replication and Radiation Response of Aedes Albopictus Cell Line in Vitro
Made available in DSpace on 2014-12-11T22:22:26Z (GMT). No. of bitstreams: 1 7511806.pdf: 2943503 bytes, checksum: 2bc8b8171b4817764b2630a6da76cefe (MD5) Previous issue date: 1974
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Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… outcomes, and also statins can improve the response to radiation in vitro. Furthermore, statins have been shown to target the cells with stem like-properties called cancer stem cells (CSCs) which are known to be important in the pathogenesis of aggressive breast cancers. However, the effects …
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Radiation response and optical characterization of carbon based thin-films prepared by saddle field plasma enhanced chemical vapor deposition
… material properties. Detection of ionizing radiation is an important application that carbon and diamond based materials, which offer a promising detection material with low manufacturing cost and a variety of physical characteristics for different detection applications. In the current …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
<p>Radiation injury in the esophagus occurs with high frequency from the treatment of non-small cell lung cancer (NSCLC). Radiation esophagitis is an acute normal tissue toxicity that negatively affects treatment efficacy by limiting dose and potentially interrupting radiation therapy. Clinical …
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Radiation modelling of vacuum field emission devices
… It has been proposed that these devices are "radiation insensitive" since they do not have a solid state junction as in other modern electronic devices. Radiation testing has been conducted to characterize the radiation response for these devices however, minimal supporting modeling has been …
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Atomistic simulations of radiation damage in amorphous metal alloys
… studies have characterized the atomic-level radiation response mechanisms in irradiated crystalline alloys, comparatively little is known regarding the mechanisms of radiation damage in amorphous alloys. Knowledge of collision cascade dynamics is lacking, both with respect to the possibility …
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Yeast-based impedance biodosimetry for retrospective assessment of radiation exposures
… techniques can be used to determine the radiation dose to populations and the environment. This work investigates the feasibility of Saccharomyces cerevisiae yeast cells as fortuitous dosimeters for retrospective assessments of exposures following radiological accidents using impedance …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… accepted that energy is required for repair of radiation-induced damage in living cells. Some of this energy is probably provided by adenosine triphosphate (ATP), which is derived from energy substrates via energy metabolism. This dissertation follows two general avenues. The first explores the …
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Cell-type-specific responses to DNA damage from acute and chronic radiation
It is well understood that radiation causes damage to DNA, which triggers a DNA-damage response often centred on the signalling pathways of ATM, with the subsequent involvement of proteins such as p53, p21 and H2AX. Many experiments have been performed with cell lines derived from different origins …
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