Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"radial glia"”.
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Radial glia in the developing superior colliculus : evidence for a midline barrier
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1991.
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Radial Glia and the Migration of Young Neurons in the Adult Avian Brain
… reactivity to GFAP we identified these cells as radial glia. The same antibody also stained a subset of brain astroglia and reacted with non-brain material such as mesenchyme, Sertoli cells and the Z-line of muscle. A weaker reaction was obtained with erythrocytes and some endothelial cells. …
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Effects of environmental complexity on neurogenesis in the hippocampal dentate gyrus
… for i) vimentin, a marker of radial glial cells, ii) BDNF (brain-derived neurotrofic factor), a neurotrophin involved in neuron proliferation/survival, iii) PSA-NCAM (the polysialylated form of the neural cell adhesion molecule), a molecule associated with neuronal migration. …
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Identification, regulation and lineage tracing of embryonic olfactory progenitors
… and temporal understanding of embryonic OE neuroglial progenitors has been stalled by the paucity of identifiable genes able to distinguish individual candidate progenitors. In the developing CNS, radial glia serve as both neural progenitors and scaffolding for migrating neuroblasts and are …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… basal intermediate progenitors (bIPs) and basal radial glia (bRG) based on morphology and proliferative capability. It was observed that a higher number of cell processes positively correlates with proliferation. The molecular mechanisms that drive this connection are only partially understood. …
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THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… gene regulatory network in radial glia, and predicted a higher affinity of GLI3 for the modern allele in an enhancer linked to KLF6, consistent with its role in balancing proliferative and differentiative radial-glia divisions. Leveraging a prioritisation pipeline that …
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Characterizing the Hypothalamic Functions of Irx3 and Irx5 in Energy Balance Regulation
… in a previously unreported population of radial glia-like cells (RGL) in postnatal mouse hypothalamus, which could be targeted by Ins2-Cre. These RGLs harbor a gene signature highly reminiscent to neural stem cells (NSC) and hold the potential to give rise to other neural cells in …
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UNDERSTANDING THE CELLULAR AND GENE-REGULATORY MECHANISMS UNDERLYING THE MESENCHYMAL TRANSITION OF EPENDYMOMA TUMOR CELLS USING OMICS APPROACHES
… cell lineages that resemble developmental radial glia cells and a tumor cell population with a mesenchymal gene expression profile that is associated with poor prognosis. However, little is known about the cellular and molecular mechanisms that enable the initiation, maintenance, and …
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Investigating the role of ZEB2 in the establishment of neuroepithelial architecture and axon tract formation
… cells (NECs) before the switch to radial glia (RGCs). By establishing a human embryonic stem cell (hESC) model of ZEB2 heterozygous loss-of-function we show that this gene modulates the changes in cell-cell contacts at the transition from NECs to RGCs. Upon partial loss of ZEB2, …
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Discovery of the novel mouFSnrp gene and the characterisation of its in situ expression profile during mouse neurogenesis
… appears to be preferentially continued via the radial glial lineage. mouFSnrp expression is carried forward via the neurogenic radial glia into their daughter neuronal progeny as well as postnatal astrocyte. In the postnatal brain, mouFSnrp gene transcripts were also observed in the olfactory …
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Functional analysis of transcription factor mScrt2 in cortical neurogenesis
… Generierung mehrerer neuronaler und glialer Zelltypen hervorgeht. Die Mehrheit aller Zelltypen, die während der Kortikogenese gebildet werden, entsteht durch die Zellteilung von pluripotenten Radial-Glia Vorläufern (RGPs) in der Ventrikularzone. RGPs sind außerdem der Ursprung einer …
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Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells
… These cells are cultured as monolayers, have a radial glia like appearance, self renew and form all three neural cell types, neurons, astrocytes and oligodendrocytes upon differentiation. More recently human foetal neuroepithelial like (NES) stem cells have been produced from five week old human …
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Tissue injury and remodeling in rat hippocampal dentate gyrus following sodium-potassium-ATPase inhibition.
… pump inhibition triggers the appearance of a radial glia-like cell population that undergoes time-dependent cell dispersion and rearrangement. (4) We found that pump inhibition can simultaneously trigger cell death as well as upregulate progenitor cell proliferation. Migration of such newly …
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An emerging role for tcf7l2 at the nexus between metabolic regulation and social behavior
… in differentiation and development of those radial glia-like cells. The data suggest a critical role for Tcf7l2 in maintaining tanycyte pluripotency and the ability of those cells to differentiate into POMC-expressing neurons, a mechanism that permits plasticity of metabolism and behavior in …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
… NSCs divide in a similar manner to the outer radial glia of the mammalian brain and both factors have orthologues, namely ARX and NKX2.1. Remarkably, we showed that these factors have conserved roles in the NSCs of the visual system, which have a different developmental origin.
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Effects of prolonged mitosis on neural stem cells in vivo during development
<p>Microcephaly patients are born with a brain size >3 standard deviations below normal and have mild to severe cognitive deficits. 12 microcephaly-linked genes identified in human genetics studies encode microtubule/centrosome-associated proteins and mutations in these genes are strongly tied to …
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Astrocytic Sonic Hedgehog signalling in development and disease
… among neurons, astrocytes, and microglia, and defines the specialised characteristics of mature glial cells (Xie et al., 2022; Farmer et al., 2016; Hill et al., 2019). This adaptation ensures glia that are finely tuned to the specific demands of the neural microenvironment. Indeed, …