Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"rad52"”.
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Mechanisms of human RAD51 regulation by RAD52 and BRCA2
… organisms – the tumour suppressor, BRCA2, and RAD52. Recent evidence suggests that human RAD52 becomes essential for viability in cancer cells lacking BRCA2, making its activity an attractive target for potential therapeutic strategies. However, the mechanisms by which RAD52 and BRCA2 …
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Análisis del papel de RAD52 en la estabilidad genómica de C. albicans
… de pérdida de heterozigosidad en mutantes rad52-¿¿ de C. albicans. El gen RAD52 en C. albicans es absolutamente necesario para los eventos mediados por la recombinación homóloga, y su ausencia produce fuertes defectos en integración homóloga, reparación de DNA y mantenimiento de telómeros. …
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Regulación de la rutas de tolerancia a daños replicativos dependientes de RAD6, RAD5 y RAD52 durante el ciclo celular en Saccharomyces cerevisiae
… trabajo se demuestra que las proteínas de HR Rad52, Rad51 y Rad57 colaboran con la maquinaria de TLS (ubiquitinación de PCNA mediada por Rad6/Rad18 y las polimerasas Rev1/Pol z) para reparar las lesiones de ssDNA a través de una función no recombinogénica, y en consecuencia son necesarias para …
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DNA repair and genomic instability in yeast aging
… from the rDNA locus by homologous recombination. rad52 mutant cells, defective in DNA repair through homologous recombination, do not accumulate ERCs with age; likewise, mutations in other genes of the RAD52 class that have varying effects on homologous recombination have corresponding effects on …
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Characterization of the DNA repair role of the Saccharomyces cerevisiae NSE1 gene
… analyses, we inferred a role for Nse1 in the Rad52-dependent repair pathway. Our PRR experiments further support our genetic results, as the newly synthesized DNA does not attain the normal size in UV irradiated nse1-101 cells. On the basis of these and other studies we have provided evidence …
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Molecular and Genetic Analysis of the Role of Ku in Silencing and Telomere Function in Saccharomyces Cerevisiae
… regulation (YKU70, BDF1, ANC1, RAD50, TEL1, RAD52). Double mutant analysis revealed functional relationships between genes by generating a network of 241 synthetic interactions between 144 genes at 30°C and a network of 355 synthetic lethal interactions between 146 genes at 37°C. The …
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Zur Funktion des MPH1-Gens von Saccharomyces cerevisiae bei der rekombinativen Umgehung von replikationsarretierenden DNA-Schäden
… der Hypostasis von mph1 zu rad51, rad52 und rad55 sind mph1 Mutanten nicht defekt in der homologen Rekombination, vielmehr zeigen sie einen Hyperrekombinationsphänotyp im sgs1 Stammhintergrund. Weitere genetische Interaktionen von mph1 mit apn1, apn1 apn2, mre11, sgs1, top3 und …
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HMO2, a yeast HMGB protein that preferentially binds to DNA ends
… in homologous recombination. Also hmo2∆ and hmo2∆rad52∆ have slower growth phenotype in presence of hydroxyurea thus indicating that HMO2 might play important role in recovery of stalled DNA replication forks.
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Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
… wird aufgehoben durch Deletion der Gene RAD51, RAD52, RAD55 und RAD57, die für die Bildung des Rad51-Nukleoprotein-Filament verantwortlich sind. Das Rad51-Nukleoprotein-Filament vermittelt den Prozess der Strang-Invasion an homologen DNA-Duplexen. Deletion der Gene MEC1, RAD53, RAD9, RAD17 und …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… replication (BIR), such as accumulation of RAD52 and POLD3, and C-circles, were upregulated. Overall, these results indicate that C-rich telomeric dilncRNA is necessary for the controlled engagement of selected DDR factors at ALT telomeres and is essential for survival of ALT cancer cells. …
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ROLES OF INOSITOL DIPHOSPHATES IN DNA REPAIR AND EFFECTS OF ASPIRIN ANALOGUES ON OESOPHAGEAL CANCER
… repair. GFP-tagging the proteins Ung1, Apn1 and Rad52 in kcs1Δ proved to be of little use as it failed to show exact localisation, movement and functionality status of these proteins following bleomycin insult. The enzymes accountable for the dephosphorylation of the IDPs in vivo are the …
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The influence of chromatin in DNA-RNA hybrid metabolism
… ni tampoco mediante una acumulación de focos de Rad52. En esta tesis profundizamos en el estudio de dichos mutantes de histonas, analizando los niveles de pérdida de heterozigosidad o pérdida de cromosomas y hemos conseguido medir la longitud y la frecuencia de los R loops gracias a la puesta a …
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Functional and evolutionary analysis of sugar transporters in Kluyveromyces marxianus
… improve homologous recombination repair, the RAD52 gene, involved in homologous recombination in S. cerevisiae, was expressed in K. marxianus. A strain expressing this gene showed a seven-fold increase in homologous recombination-mediated repair, albeit from a low base. These tools were used …