Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"rabies virus"”.
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Rabies virus soluble antigens : a biochemical and biophysical study of the major antigen of rabies virus.
… the largest of several antigens demonstrable in rabies-infected suckling mouse brains. The biochemical and biophysical properties of the antigen were studied with a view to elucidating its contribution to the intracellular synthesis and the structure of the virus particles. Extracts of normal and …
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Adoptive transfer of immunity to rabies virus
… was used in efforts to transfer immunity to rabies virus adoptively in various laboratory and wildlife animals. Transfer factor activity was measured by observing the mortality ratio of treated and untreated animals challenged with CVS-27 rabies virus, by the lymphocyte proliferation assay …
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Cross-scale assessment of environmental variation on RABV reservoir Desmodus rotundus
… and pandemic risk. In Latin America, the rabies virus (RABV) is regularly transmitted by the common vampire bat (Desmodus rotundus). Rabies virus is extremely lethal, killing nearly 100% of infected individuals. Desmodus rotundus is a sanguivorous (blood-feeding) species that can easily …
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Applied epidemiology of infectious diseases in Australia
… is no reliable treatment for Australian Bat lyssavirus (ABLV) or rabies virus infection upon the onset of symptoms, treatment must occur as either pre or post-exposure prophylaxis. The National Human Rabies Immunoglobulin Database records information of people who have received Human Rabies …
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Applied epidemiology of infectious diseases in Australia
… is no reliable treatment for Australian Bat lyssavirus (ABLV) or rabies virus infection upon the onset of symptoms, treatment must occur as either pre or post-exposure prophylaxis. The National Human Rabies Immunoglobulin Database records information of people who have received Human Rabies …
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Design of novel delivery systems to probe alternative routes of administration for a self-amplifying RNA rabies vaccine
… DDA), was designed to deliver a SAM vaccine. The rabies virus was used as a model, as there is an established correlate of protection (neutralising antibodies) and there exist efficacious vaccines in the market (e.g. Rabipur) to be used as comparators. To this end, a SAM vaccine encoding the …
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Laukinių ir naminių gyvūnų pasiutligės epidemiologija, diagnostika ir imunoprofilaktika Lietuvoje /
Rabies is one of the oldest and most dangerous human and animal diseases. This is a disease that is transmitted directly from animal to animal and from an animal to a human being. People usually contract this disease from stray domestic animals therefore a realistic threat is posed to everyone to …
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The study of highly pathogenic emerging zoonotic virus envelope proteins through pseudotyped virus generation
Emerging zoonotic viruses pose an increasing threat, causing outbreaks with high rates of morbidity and mortality and frequently significant economic implications. Often, there is a lack or shortfall of effective prophylaxis and diagnostic capabilities. Research towards their development, together …
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Rabies serology: relationship between assay type, interpretation, and application of results
… consist of vaccine type, potency, and virus strain; vaccination route and schedule; and individual host factors. Although, perhaps, often overlooked, it is essential to have a basic understanding of the laboratory methods used to measure and assess the host’s immune status. The …
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The development of novel methods for the targeting and manipulation of neural circuits in vivo
… a monosynaptically restricted Self-Inactivating Rabies virus (SiR) which enables the targeting of neural circuits without cytotoxicity. To expand the scope of SiR we further developed the technology in two directions: A) By incorporating the CRISPR/CAS9 gene-editing machinery into the SiR genome …
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Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape
Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1 and NS2. We show that both BRSV NS proteins …
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Immune responses against recombinant poxvirus vaccines that express full-length lyssavirus glycoprotein genes
Rabies is a fatal but preventable neurotropic disease of potentially all mammals. The disease is caused by lyssaviruses. Rabies is recognized as the 10th most common lethal infectious disease in the world, rendering it one of the most feared zoonotic diseases known to man. Nevertheless, rabies can …
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An evaluation of reverse transcription loop-mediated isothermal amplification (RTLAMP) for diagnosis of rabies.
Rabies is a neurological disease caused by a lyssavirus belonging to the family rhabdoviridae. The causative agent has a global distribution (except Antarctica) resulting in an estimated 59,000 human deaths worldwide. The true disease burden and public health impact due to rabies remain …
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An evaluation of reverse transcription loop-mediated isothermal amplification (RTLAMP) for diagnosis of rabies.
Rabies is a neurological disease caused by a lyssavirus belonging to the family rhabdoviridae. The causative agent has a global distribution (except Antarctica) resulting in an estimated 59,000 human deaths worldwide. The true disease burden and public health impact due to rabies remain …
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Rabies in Virginia, 1989-2003: With particular attention to animals, geographic distribution, and virus variant
<p>Objectives: The description of the raccoon rabies epizootic in Virginia over fifteen years (1989-2003). Methods: Using simple statistical methods and a geographic information system (GIS)-based approach, and fifteen years worth of animal surveillance data, the progress of this epizootic has been …
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Vaccine Development Strategies for Crimean-Congo Hemorrhagic Fever Virus and its Tick Vector
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus with an extensive geographic range and complex ecology. Ticks within the Hyalomma genera are the primary vector and reservoir of the virus and maintain the virus through a cryptic tick-vertebrate-tick cycle in nature. However, …
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Analysis of neural circuits in vitro
… cultures using recombinant adeno-associated virus and characterized the spatial resolution, as well as the reliability of stimulating action potentials. However, there were limitations to this technique that would render circuit maps ambiguous and incomplete. More recently, the engineering of …
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Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… project to glioma remain unclear. We leveraged rabies virus and herpes simplex virus (HSV)-based transsynaptic tracing techniques in the rodent brain to define a whole-brain connectome of GBM-projecting neurons. We found that, remarkably, GBM receives inputs from all over the brain and are …
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Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations and Identification of Novel Host Barriers to Poliovirus Neuropathogenesis
Neurotropic viruses comprise some of the worlds most widespread and deadly pathogens, including West Nile virus, rabies virus, and poliovirus. Poliovirus, as a model neurotropic virus, is also an RNA virus. RNA viruses have high mutation rates and a propensity to revert attenuating mutations, …
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