Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"rab proteins"”.
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Analysis of Hepatocyte Secretion Pathways: A Case Study on Hepatic Apolipoproteins, Serum Albumin, and Hepatitis C Virus
… macromolecular lipid-protein complexes, the lipoproteins. The hepatocyte is also the site of infection of several hepatotropic viruses. Of these, hepatitis C virus (HCV) is peculiar due to its close structural and functional association with the hepatic lipoproteins. All these cargoes are …
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Characterization of the entry mechanisms utilized by the alphavirus venezuelan equine encephalitis virus to infect mosquito cells
… This endocytic pathway utilizes several proteins in the mammalian cell, including the clathrin protein, the small GTPases known as Rab proteins and the large GTPase dynamin. These proteins have been shown to play a role in the entry of several viruses and are thought to be involved in …
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Deciphering The Role of Huntingtin In Endosomal Functions
… largely remains elusive.</p> <p>Rab proteins, part of the Ras superfamily of small GTPases, govern cargo trafficking through endosomal pathways. Upon endocytosis into early endosomes regulated by Rab5, the endocytosed cargo can either be recycled back to the plasma membrane (via …
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Differential Selection Pressure Among Duplicated Genes In Teleosts
… material subject to selection. Using myo5, rab11, and rab27 gene families as models, I examined the evolutionary rate differences among duplicated genes and whether selective forces (e.g. purifying selection or positive selection) could be identified in one or both duplicated gene clades. I …
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Identification of the TPC2 interactome reveals TSPAN10 and OCA7 as key players in the biogenesis of melanosomes
… enzymes, Tyrosinase and Tyrosinase Related Proteins 1 and 2. Furthermore, correct melanosome maturation requires remodeling of the melanosome membrane, recycling of membrane trafficking machinery, generation of intraluminal amyloid fibrils with the correct structure for melanin packaging, …
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The Arf GTPase exchange factor Sec7p interaction network:
… ensure the proper sorting and delivery of cargo proteins to their destination while maintaining Golgi homeostasis the coordination of all transport events to and from this organelle is required. Although a cascade of activation events has already been reported for Golgi Ypt/Rab proteins that …
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Investigating the neuroprotective role of carboxyl-terminus of Hsc70-interacting protein (CHIP) in healthy aging
… the final step of an enzymatic cascade priming proteins for degradation through the ubiquitin-proteasome system and thus are crucial to protein quality control. Carboxyl terminus of Hsp70-interacting protein (CHIP), one such ligase, was initially found to facilitate the polyubiquitination and …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
… tail and the retromer complex of endosomal coat proteins. Additionally, removing either 3 or 10 C-terminal amino acids from sst2 alters the pathway through which sst2 recycles to the plasma membrane. We also determined that the expression of SHANK3, a PDZ domain containing protein, could alter …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… mechanism that regulates the majority of proteins in a eukaryotic cell. Protein phosphorylation has been implicated in various cellular processes including glycogen metabolism, cell cycle control, RNA splicing, DNA synthesis, muscle contraction and mitosis. Protein kinases and phosphatases …
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Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… However, it raised the question of how the proteins characteristic for each compartment are transported to their destination (Bonifacino and Glick, 2004). This study is especially focusing on the connection between the Golgi apparatus and the endosomal compartment, mediated by two parallel …