Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"rab"”.
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Rab-domain dynamics in endocytic membrane trafficking
… molecular understanding of the endocytic system. Rab-GTPases have emerged as architectural key element thereof: Individual family members localize selectively to endosomal compartments, where they recruit a multitude of cytoplasmic effector proteins and coordinate them into membrane sub-domains. …
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Activation of lipid kinase VPS34 by Rab GTPases
… by membrane properties and by members of the Rab family of small G proteins, which are important for orchestrating intracellular vesicle sorting and transport. However, their detailed activation mechanisms have been poorly understood. Firstly, we found that high curvature, negative charge, …
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
… neurodegenerative disorder. As PD remains incurable, only symptomatic treatment is available for patients. To identify targets for therapeutic intervention and also recognise early stage disease biomarkers, current research revolves heavily around the known genetic causes of PD. These gene …
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The Rab' in Cairo : a window on Mamluk architecture and urbanism
… more important elements in its urban fabric, the rab' or apartment building. This building type is investigated via its extant examples and the extensive archival collection from the Fatimid, Ayyubid and Mamluk periods. The salient features of the rab' are identified, and its variations noted. The …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Identification and characterization of components of rab-6-mediated trafficking in caenorhabditus elegans
… synaptic signaling mechanisms can be controlled. Rab GTPases 6.1 and 6.2 have been profiled for their role in trafficking of GLR-1 in neurons. RAB-6.2 plays a role in the retrograde trafficking of the AMPA-type glutamate receptor GLR-1 (Zhang et al., 2012). Activated Rab GTPases regulate membrane …
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The Recycling GTPase, RAB-10, Regulates Autophagy Flux in <i>Caenorhabditis elegans</i>
… identified in our screen was the small GTPase, RAB-10, a regulator of endocytic trafficking from yeast to mammals. Our results show that <em>rab-10</em> loss of function alters the localization pattern of the autophagy reporter, GFP::LGG-1 in wild type and <em>daf-2(e1370)</em> mutant seam …
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RabAnalyser: a computational framework to explore the cell-to-cell variability of Rab GTPases organization
L'abstract è presente nell'allegato / the abstract is in the attachment
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Cryo-EM structural exploration of human VPS34 complexes and their activation by RAB GTPases and NRBF2
… VPS34 complexes can be specifically activated by RAB GTPases RAB1A (for complex I) and RAB5A (for complex II), but the mechanistic details of how this specificity is achieved have remained elusive due to a lack of high-resolution structural data for human VPS34 complexes. In this work, I used …
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Genetic Analysis of Grinder Formation in Caenorhabditis Elegans: Regulation by RAB-6.2 and Its GTPase Activating Protein EAT-17
… I found that eat-17 encodes an ~825 amino acid Rab GTPase activating protein with a series of C-terminal coiled-coil domains. Its closest human homolog is Evi5, a putative oncogene whose function is not currently understood. Rabs are key regulators of vesicle transport, and cycle between active, …
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An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11
Rab GTPases are the largest family of the Ras superfamily and are key regulators of membrane trafficking within the cell. There are over 60 members of the Rab family which localise to specific membrane compartments and interact with effector proteins to regulate membrane trafficking processes, such …
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
… and Salmonella; selectively recruit host Rab GTPases to their vacuolar membranes to establish replicative permissive niches within their host cells. Rab GTPases coordinate many aspects of endocytic and exocytic cargo delivery. We determined that the A. phagocytophilum-occupied vacuole …
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Investigation of the effect of a probiotic-supplemented diet on the haemocyte proteome of the abalone Haliotis midae
… 1 subunit gamma, V-type proton ATPase subunit B, Rab 1 and Ra-related protein Rab 1A. Differential expression of COP9 signalosome subunit 4 (up-regulated) and Ras-related protein Rab 1A (down-regulated) was confirmed by western blot analysis. Bioinformatics analysis revealed proteins with immune …
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A Situational Assessment of Student Leadership: An Evaluation of Alternate Forms Reliability and Convergent Validity
… SALSA Form B showed a significant correlation (rAB = .906, p < .01). Dimension scores on the two forms ranged from rAB = .475 to rAB = .804. Study 2 evaluated the convergent validity between the SALSA and the Western Kentucky University Center for Leadership Excellence assessment center. SALSA …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… movement, and fusion. One class of proteins, the Rab GTPases, is required for docking and fusion of transport vesicles with their target membrane. These proteins are regulated by their state of nucleotide binding, with GTP-bound Rabs thought to provide specificity to transport steps via their …
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Evolutionary and Developmental Survey of Genes Involved in Chordate Pigmentation
… have been studied. <br></br><br></br> Given Rabs regulate a plethora of trafficking steps, the members belonging to this family are central to the transport of molecules involved in pigmentation. Moreover, comprehending the evolution of Rab family is relevant to understand the establishment …
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Engineering Optogenetic Control of Endocytic Recycling: Controlling Rab11 Function in Drosophila melanogaster using Engineered Light-Responsive Nanobodies
… one main family of transport regulators is the Rab GTPases. Rab GTPases utilize GTP to move materials throughout the cell by binding to the membrane of vesicles or endosomes, and trafficking distinct, membrane-associated components throughout the cell. One member of this large family of proteins …
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Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
… three central paralogous trafficking families: Rabs, SNAREs and Rab-GAPs, which have defined roles in specific trafficking events. Further, proteomics was used to analyse a representative SNARE complex to explore compositional conservation between kinetoplastids and Opistokhonts. Overall there …
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