Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"rVSV"”.
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Development and Characterization of a Recombinant Vesicular Stomatitis Virus (rVSV) for the Treatment of Glioblastoma
… recombinant vesicular stomatitis virus (rVSV), an enveloped, negative strand RNA virus, has shown promising results in preclinical studies. Tumor selectivity of VSV is thought to be associated with tumor specific defects in the interferon (IFN) pathway. However, largely due to …
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Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus: A New Live Vectored Vaccine for Human Norovirus
… Recombinant VSV expressing VP1 protein (rVSV-VP1) was recovered from an infectious cDNA clone of VSV. Expression of the capsid protein by VSV resulted in the formation of human NoV virus-like particles (VLPs) that are morphologically and antigenically identical to the native virions. …
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Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
… Recombinant vesicular stomatitis viruses (rVSV) expressing foreign glycoproteins have shown promise as both experimental vaccines and as a surrogate model at a lower biosafety level (BSL-2), called pseudotypes, for several viral pathogens. Herein, rVSV pseudotypes expressing the CCHFV …
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POST-EXPOSURE TREATMENT OF MARBURG VIRUS ANGOLA DISEASE IN NON-HUMAN PRIMATES USING RECOMBINANT VESICULAR STOMATITIS VIRUS VECTORS
… a recombinant vesicular stomatitis virus (rVSV) expressing the Musoke strain glycoprotein (GP) of MARV protects macaques against MARV Musoke and Angola variants, as well as Ravn virus. The vector is also effective as a post-exposure treatment against a high dose homologous MARV Musoke …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
… virus expressing the Junin virus glycoprotein (rVSVΔG-JUNVGP) for the development of countermeasures against arenaviruses. First, we evaluated rVSVΔG-JUNVGP as a vaccine against lethal Junin virus (JUNV) challenge in a guinea pig model. Currently, there are no JUNV vaccines licensed by the …
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Phylogenetics and New Approaches to Vaccine Development for West Nile
… edge. Recombinant vesicular stomatitis virus (rVSV) based vaccines cleverly incorporate reverse genetics to recover a recombinant virus expressing a foreign antigen of interest. rVSV vectored vaccines expressing the LSU-AR01 envelope (E) glycoprotein were engineered and administered to mice in …
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Investigation of the Vesicular Stomatitis Virus Matrix Protein: Uncoating and Assembly
… using a VSV, containing fluorescent M protein (rVSV-M-Lumio-Green). I found that uncoating occurs primarily in early endosomes and results in the majority of M remaining associated with the endosomal membrane which eventually localizes to the perinuclear recycling endosomes. A small fraction of …