Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"rRNA processing"”.
-
Characterization of Yeast 18S rRNA Dimethyl Transferase, Dim1p
… process involves numerous cleavages of pre-rRNA, modification of nucleotides, and concomitant assembly of the ribosomal proteins onto the rRNA. Considerable information is available about the importance of conserved pre-rRNA cleavage events in ribosome biogenesis; however, very little is …
-
The functional characterization of a novel protein, Liat1
… and that cells lacking Liat1 have defects in rRNA processing. Collectively, our data indicates that Liat1 participates in LLPS in the dense fibrillary component of the nucleolus in a manner regulated by Jmjd6; and suggest that it plays a significant role in rRNA processing and/or assembly as …
-
Investigations into Why Human (but not mouse) KU70/80 is Essential Reveal a Role for Human KU70/80 in Ribosome Biogenesis
… human Ku70/80 null cells exhibit ribosomal RNA (rRNA) processing defect and consequent shutdown of protein synthesis offer a direct explanation for cell viability loss. Through a series of complementary experiments, we also show that it is human Ku80that is required for Ku70/80 nucleolar …
-
Investigating WDR12 as a Therapeutic Target in Breast Cancer
… show that WDR12 knockdown induces ribosomal RNA (rRNA) processing defects resulting in strong growth inhibition in all breast cancer cells tested, however only a subset of lines displayed short-term cell cycle defects. To further understand the cellular consequences of WDR12 suppression, we …
-
Role of SMU Homologues in Pre-mRNA Splicing During Maize and Arabidopsis Development
… mto38/zmsmu2-1endosperm revealed that defective rRNA processing and inefficient proteinsynthesis in the mutant can explain the mutant endosperm phenotypes.Furthermore, splicing of multiple pre-mRNAs is altered in zmsmu2-1endosperm, indicating a regulatory role for ZmSMU2 in pre-mRNA splicing. …
-
Transcriptomic Signatures of Skeletal Muscle Adaptation: Disuse, Rehabilitation, and Resistance Exercise Intervention
… whereas pathways associated with translation, rRNA processing, and polyamine metabolism are positively correlated with strength. In summary, our study unveils novel insights into the molecular mechanisms driving skeletal muscle responses to disuse and resistance exercise training. By …
-
Novel Insights into the Regulation of Autophagy in Saccharomyces Cerevisiae
… and other factors that are also involved in rRNA processing and translation initiation. Interestingly, IML1, NPR2, NPR3 and PBP1 are also important for Rli1p-depletion-induced mitophagy. These results strongly suggest the mechanistic link between SL-induced autophagy and ribosome biogenesis …
-
The nucleolar protein NOC1 is essential for ribosome biogenesis, and its reduction activates a novel MYC-p53 axis mediating nucleolar stress
… crucial step in this mechanism is represented by rRNA processing and maturation. Defects in this process result in a condition known as nucleolar stress, a field of intensive studies for its relation with human diseases. In Drosophila, defects in ribosome production and functionality is associated …
-
Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… III enzyme from a spirochete and its role in processing rRNA transcripts from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal …
-
Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… III enzyme from a spirochete and its role in processing rRNA transcripts from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal …
-
Characterization of a novel family of nucleolus localized RNAs
… domain where ribosomal gene transcription, pre-rRNA processing, and the initial steps of ribosome sub-unit assembly take place. In human cells, nucleoli are formed around nucleolar organizer regions (NORs) located on the short arms of the five acrocentric chromosomes. NORs are composed of tandem …
-
Phenotypic and transcriptomic consequences of ribosomal DNA copy number variation in Caenorhabditis elegans and Saccharomyces cerevisiae
… forms the template for mature ribosomal RNA (rRNA) and shows considerable sequence conservation through evolution. In eukaryotic genomes rDNA is present in one or more tandem repeat arrays, with copy number variation (CNV) commonly observed in inter- and intra-species comparisons. rDNA CNV has …
-
Discovering non-equilibrium mechanisms that regulatestructure and function of biomolecular condensates usingphase-field modeling
… a phase-field model that explicitly accounts for rRNA-protein interactions in the nucleolus and the non-equilibrium reaction of rRNA transcription, we show that the coarsening of fibrillar centers is arrested leading to a preferred size. Altering this size affects rRNA export and processing from …
-
Mechanisms and Evolution of Mitoribosomal Small Subunit Biogenesis
… which there are over 200 in yeast, orchestrate rRNA processing, folding, and modification. While the vast majority of proteins are made by cytoplasmic ribosomes in eukaryotes, a select few proteins are made by specialized ribosomes in the mitochondria. The existence of these mitoribosomes points …
-
Funktionelle Analysen virulenzrelevanter und essentieller Gene in Candida albicans
… Rolle beim Chromatin-Remodeling bzw. bei der rRNA-Prozessierung haben. Nachdem sich alle Gene auch in C. albicans als essentiell herausgestellt hatten, wurden konditional letale Mutanten hergestellt, in denen die Gene durch induzierbare Deletion mit Hilfe der site-spezifischen Rekombinase FLP …