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Showing 1 to 20 of 735 for “"rRNA"”.
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Characterization of Yeast 18S rRNA Dimethyl Transferase, Dim1p
… process involves numerous cleavages of pre-rRNA, modification of nucleotides, and concomitant assembly of the ribosomal proteins onto the rRNA. Considerable information is available about the importance of conserved pre-rRNA cleavage events in ribosome biogenesis; however, very little is …
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The Development Of Peptide Ligands To Target H69 Rrna
<p>ABSTRACT</p> <p>THE DEVELOPMENT OF PEPTIDE LIGANDS TO TARGET H69</p> <p>by</p> <p>DANIELLE NICOLE DREMANN</p> <p>December 2015</p> <p>Advisor: Prof. Christine S. Chow</p> <p>Major: Chemistry (Biochemistry)</p> <p>Degree: Doctor of Philosophy </p> <p>In the development of peptide ligands to …
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Speziesidentifizierung mittels vergleichender Sequenzanalyse des mitochondrialen 12S-rRNA-Gens
RNA (rRNA), die eine wichtige, primär funktionale Rolle in der Zellphysiologie einnimmt. Die Gene dieser rRNA lassen sich in hochkonservierte und hochpolymorphe Bereiche unterscheiden. Während in den konservierten Regionen kaum Mutationen zu finden sind, werden in den polymorphen Abschnitten je …
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Nmr Solution Structures Of Two Hairpins Of E. Coli 16s Rrna: The Effects Of Mutations And Chemical Modifications On Structure And Function Of Rrna
… hairpin. </p> <p>The 970 hairpin of E. coli 16S rRNA contains two modified nucleotides, m2G966 and m5C967. The two modified nucleotides in the 970 loop are involved in some important biological functions, for example, the m2G966 of the 970 hairpin interact with C34 of P-site bounded tRNA in the …
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Improving an rRNA depletion protocol with statistical design of experiments
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Interaction of the Bacillus stearothermophilus ribsosomal protein S15 with rRNA
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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rRNA transcription as potential therapeutic target in triple negative breast cancers
… The nucleolus size correlates with the level of rRNA transcription and the level of ribosome biogenesis. In recent years the rRNA transcription has emerged as novel target for anti-cancer therapy and number of specific RNAP1 transcription inhibitors are currently undergoing clinical trials as …
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Method Development And Applications To Screening And Characterization Of Rrna-Targeting Small Molecules
<p>A series of single ring aminoglycoside analogues was tested for binding to a model RNA representing the A site using electrospray ionization mass spectrometry (ESI-MS). Several of the synthetic analogues with low molecular weights were found to bind to the RNA with affinities comparable to the …
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16S rRNA sequence analysis of silver carp microbial community in eDNA water samples
… this, DNA was extracted and analyzed through 16S rRNA sequencing on the Illumina MiSeq platform yielding 25 million reads and over 16,000 OTUs after initial clean up. Following analysis, there were multiple microbial groups, in particular 127 OTUs within the Fusobacteria phylum previously …
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X-Ray crystal structure of a ribosomal protein S6, S15, S18 : rRNA complex from T. thermophilus, and investigation of conformational changes in 16S rRNA fragments from B. stearothermophilus during ribonucleoprotein assembly
… ribosomal proteins S6, S15, S18, and a minimal rRNA binding site (T4 RNP) containing two different three-helix junctions was solved to 2.6 A. The protein S15 contains four bundled a-helices and binds the rRNA along the minor groove of helix 22 and contacts elements of both three-helix rRNA …
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Degradation of 23S rRNA in Azithromycin-Treated Ribonuclease Mutants of <em>Escherichia coli</em>.
… rates were measured. Degradation of 23S rRNA was examined by hybridization with a 23S specific probe. Ribonuclease II and polynucleotide phosphorylase mutants demonstrated hypersensitivity to the antibiotic and showed a greater extent of 23S rRNA accumulation, suggesting that these two …
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rRNA Promoters as Targets for Transcription Factors: Structural and Functional Studies of PhERI and CarD
… polymerase is mostly located at ribosomal RNA (rRNA) promoters, actively transcribing the large, structured RNAs required for protein translation. As resources become more scarce, RNA polymerase directly responds to cellular signals that lead to the repression of rRNA transcription. This …
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Multilayered regulation of translation: roles of rRNA modifications, alternative initiation factors, and RNA-binding proteins
Translation is a central process in gene expression, where the ribosome decodes mRNA to synthesize proteins. This dissertation explores distinct regulatory layers that influence translation initiation and ribosome function, focusing on alternative initiation factors, ribosomal RNA modifications, …
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Characterization of the structure and function of a <I>Bacteroides thetaiotaomicron</I> 16S rRNA promoter
… housekeeping <I>B. thetaiotaomicron</I> 16S rRNA promoter was examined and compared to an <I>E. coli</I> 16S rRNA promoter. Our hypothesis is that there are significant differences between the promoters of these two organisms. Analysis of <I>B. thetaiotaomicron</I> sequence upstream of the …
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Aufklärung der Funktion von zwei rRNA-Methyltransferasen und Untersuchungen zur Eurekanat-Biosynthese in Streptomyces viridochromogenes Tü57
… und AviRb), die spezifische Nukleotide der 23S rRNA modifizieren. Verkürzte in-vitro-Transkripte der Domäne V der 23S rRNA dienten als Substrate für Methylierungsversuche mit beiden heterolog exprimierten rRNA-Methyl-transferasen. Durch Primer-Extension und MALDI-TOF-MS-Analytik konnten die …
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The 16S rRNA characterization of a novel "microaerophilic" Pseudomonas sp. from the oligotrophic deep subsurface environment
… DNA and amplification of the gene encoding 16S rRNA by PCR, using universal primers. The amplified DNA was sequenced and compared to 16S rRNA sequences in Genbank. High sequence similarity (98.5%) was observed with the <i>Pseudomonas mendocina</i> type strain, indicating a similarity to the …
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ANALYSIS OF MICROBIOME IN VARIOUS HUMAN MEDICAL CONDITIONS USING NEXT-GENERATION SEQUENCING OF THE 16S rRNA GENE
… in 43 healthy and diseased patients using 16S rRNA gene sequencing. We identified a rich microbial landscape, identifying over 338 bacterial taxa. Notably, <em>Acinetobacter</em>, <em>Cutibacterium</em>, <em>Acidovorax</em> and <em>Herbaspirillum</em> were prevalent in the ocular samples …
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BIOINFORMATIC PIPELINES AND MICROBIAL DATABASES FOR THE ANALYSIS OF DAIRY COWS 16S RRNA-GENE SEQUENCING DATA: A BENCHMARKING STUDY.
… per i dati di sequenziamento del gene 16S rRNA del bovino. Conclusioni In definitiva, questo studio mira a stabilire uno standard e migliorare il processo decisionale nell'analisi di sequenziamento 16S, aumentando il rigore scientifico degli studi di analisi del microbioma nelle vacche da …
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Isolation And Analysis Of Peptides Binding To Helix 69 Of E. Coli 23 S Rrna From M13 Phage Display
… 69 of domain IV or residues 1906-1924, of 23 S rRNA of E.coli were being selected from a heptapeptide phage library. An experimental system including biotin labeling of RNA and then affinity selection through four rounds was being followed. After sequencing phage clones of the fourth round, two …
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