Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"rDNA instability"”.
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Understanding The Mechanism of Genomic Instability During Replicative Aging In Budding Yeast
… hallmarks of aging is increased genomic instability. However, there remains much ambiguity as to the cause. I am studying the replicative life span (RLS) of the genetically tractable model organism Saccharomyces cerevisiae, or budding yeast using the innovative “mother enrichment program” …
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… sequences, such as the ribosomal DNA repeats (rDNA) and transposons, represent a large portion of eukaryotic genomes. Due to their repetitive nature, these loci are prone to aberrant recombination. In fact, rDNA repeat instability and increased transposon activity are hallmarks of …
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Phenotypic and transcriptomic consequences of ribosomal DNA copy number variation in Caenorhabditis elegans and Saccharomyces cerevisiae
Ribosomal DNA (rDNA) forms the template for mature ribosomal RNA (rRNA) and shows considerable sequence conservation through evolution. In eukaryotic genomes rDNA is present in one or more tandem repeat arrays, with copy number variation (CNV) commonly observed in inter- and intra-species …