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Showing 1 to 11 of 11 for “"quorum quenching"”.
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Insights into the Substrate Binding Specificity of Quorum-Quenching Acylase PVDQ
… pathogen Pseudomonas aeruginosa is a quorum-quenching enzyme that can hydrolyze the amide bond of the quorum sensing signaling N-acyl homoserine lactones (AHLs) thereby degrading the signaling molecules, inhibiting the biofilm formation and reducing virulence gene expression. Previous …
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Engineering of the quorum quenching lactonase GcL for altered substrate specificity by rational design
Quorum sensing refers to bacterial communication systems based on a signal molecule that is produced and diffuses into the environment. The concentration of this signal in the environment allows for the behavior to be controlled in a cell-density dependent manner. Quorum sensing systems utilizing …
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Effect of Spatial Organization and Population Ratios on the Dynamics of Quorum Sensing and Quorum Quenching in Bacteria Communities
Quorum sensing (QS) is a type of microbial communication used by bacteria to coordinate their behavior based on population density, regulating complex processes like biofilm formation and virulence, among other behaviors. Quorum quenching (QQ), on the other hand, disrupts this communication, …
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An Experimentally-validated Agent-based Model to Study the Emergent Behavior of Bacterial Communities
… response to gradients of chemical effectors) and quorum sensing (i.e. number density dependent regulation of gene expression), bacterial population dynamics and emergent behavior play a key role in regulating their own life and their impact on their immediate environment. Computational models that …
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The Effects of Quorum Sensing Molecules on Streptococcus mutans Biofilm
The use of quorum quenching (QQ) molecules to prevent biofilm formation has recently gained momentum. Interrupting the quorum sensing (QS) pathways of cariogenic bacteria like Streptococcus mutans could reduce the formation of dental plaque on teeth, lowering the incidences of caries and …
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Quorum sensing in the genus Hafnia - in vitro and in silico investigations
… This doctoral thesis investigates the role of quorum sensing as a specific microbial adaptive mechanism in the context of food microbiology, and further interrogates quorum quenching or microbial interference with the quorum sensing strategies of other microbes for competitive advantage with a …
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ALTERING THE AI-2 MEDIATED QUORUM SENSING CIRCUITRY TO QUENCH BACTERIAL COMMUNICATION NETWORKS
… Bacterial cell-cell communication, termed quorum sensing (QS), is mediated by signatures of small molecules. QS via these small molecules has been linked to numerous undesirable bacterial phenotypes such as biofilm formation, onset of pathogenicity, triggering of virulence genes etc. The …
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Effects of Quorum Quenchers on Aspergillus fumigatus Conidia Aggregation, Adhesion to Surfaces, and Biofilm Formation
… under static growth conditions. Microbial quorum sensing (QS) system regulates genetic competence and biofilm formation. Notwithstanding, triclosan, as a synthetic antimicrobial, disrupts QS signal in some bacteria, yeasts, and dermatophytes through blocking the biosynthesis of amino acid …
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Antimicrobial and antioxidant active packaging incorporated with hop (Humulus lupulus L.) extract: development, characterization and application in meat product
… with their in vitro (antioxidant, antimicrobial, quorum quenching, and antibiofilm properties) and in situ (test with a bologna real food system) bioactivity. This work confirmed the potential of inclusion complexation with cyclodextrins as carriers for hop β-acids and application in active …