Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"quinone oxidoreductase"”.
-
The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
… tissue. We investigated one such enzyme, NAD(P)H quinone oxidoreductase (NQO1). Elevated expression of NQO1 made GBM cells uniquely sensitive to the NQO1-bioactivatable compound β-lapachone. β-lapachone induced acute DNA damage and NAD+ depletion. However, GBM cells may evade this depletion …
-
Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes
… deficient (G6PDd) individuals. Phenolic and quinone metabolites generated via cytochrome P450-dependent pathways appear to be responsible for hemolytic effects of PQ. However, the mechanism for the hemolytic toxicity of PQ is still poorly understood. To explore the mechanism, targets, and …
-
Alimenti Funzionali e Componenti Nutraceutici come Biomodulatori
… and glutathione S-transferase, NAD(P)H: quinone oxidoreductase 1 and thioredoxine reductase) elicited by SF. The results were correlated to intracellular ROS production and cell viability after oxidative stress generated by H2O2, and confirmed the ability of SF to exert cytoprotective …
-
The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
… protection from β-lapachone, an ortho naphthoquinone that is cytotoxic to cells when activated by NAD(P)H quinone oxidoreductase 1 (NQO1). Cumulatively, these data establish a novel connection between CD38, modulation of NAD+, and prostate tumor cell metabolism, energy homeostasis, and cell …
-
Improving sulforaphane bioavailability from cooked broccoli
… ex vivo. Increased colonocyte NAD(P)H: quinone oxidoreductase 1 activity (one marker of SF bioactivity) in rats fed with no less than 7 days of a CB diet also indicates enhanced SF bioactivity by frequent intake of CB. The myrosinase-like activity of cecal microbiota is lost when the 4 …
-
Members of the Preprotein and Amino Acid Transporter Family Constitute Components of Novel Protein Import Pathways into Chloroplasts
… yet. One example is the chloroplast envelope quinone oxidoreductase homologue, ceQORH. This protein is imported into the inner plastid envelope membrane by a TIC/TOC-independent pathway and without any proteolytic cleavage. In the present study 5 proteins were shown to interact with ceQORH …
-
Untersuchungen zur Erdbeerfruchtreifung : Biosynthese von 4-Hydroxy-2,5-dimethyl-3(2H)-furanon und Enzymaktivitäten während des Reifungsprozesses
Die Fruchtreifung stellt einen hochkomplexen Prozess dar, der durch eine Reihe von biochemischen und physiologischen Veränderungen gekennzeichnet ist. Dies umfasst bedeutende Veränderungen von Textur, Farbe sowie die Bildung von geschmacks- und geruchsaktiven Verbindungen. Die vorliegende Arbeit …