Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"quinolone signal"”.
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Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… chronic infections, the Pseudomonas aeruginosa signaling molecules 3-oxo-C12-homoserine lactone and Pseudomonas quinolone signal were synthesized so that the mammalian cellular responses to their presence via an infection could be studied. It was hypothesized that differing combinations of the …
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New Sensing Modalities for Bacterial and Environmental Phenomena
… in aqueous systems, was used to detect bacterial signaling molecules. SERS was performed with three different examples of bacterial communication molecules: the universal quorum sensing molecule autoinducer-2 (AI-2), the species-specific Pseudomonas Quinolone Signal (PQS), and the stationary phase …
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The Total Synthesis of Pseudonocardia sp. Quinolone Natural Products and Studies Towards the Total Synthesis of 1β-Hydroxyalantolactone
… section concerns the total synthesis of six 4-quinolone natural products, four of which had never been synthesised before. These compounds were originally isolated from a soil bacterium of the genus Pseudonocardia, and bear intriguing structural resemblance to the Pseudomonas Quinolone Signal. …
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Nutritional modeling of bacterial infections : physiology and metabolism of Pseudomonas aeruginosa during growth in cystic fibrosis sputum
… production of the cell-cell communication signal 2-heptyl-3-hydroxy-4-quinolone (the Pseudomonas quinolone signal, PQS), a critical regulator of virulence factor production, during growth in CF sputum. Further, I use chemical analyses of CF sputum samples to develop a defined, synthetic …
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New methods for the asymmetric synthesis of α-alkylated ketones and 1,3-amino alcohols
… functions such as the role of Pseudomonas quinolone signal (PQS) in quorum sensing. Herein, we report the synthesis of its biological precursor, 2-heptyl-4-hydroxy-quinoline (HHQ) and possible isosteres of PQS; the C-3 Cl, Br and I analogues. N-Methylation of the iodide was also feasible …
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Understanding the molecular mechanism through which aspirated bile triggers chronic Pseudomonas aeruginosa infections in respiratory disease
… isolates of P. aeruginosa. Loss of Pseudomonas Quinolone Signal (PQS) production in the pigmented variants underpinned the loss of redox suppression in response to bile, perhaps a consequence of the anti-oxidant/pro-oxidant activities attributed to the PQS signalling molecule. Bile is therefore …
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Secondary ion mass spectrometry imaging of surface-bound microbial communities
… to SIMS imaging. This investigation revealed a signal enhancement for cluster-SIMS that, remarkably, only applied to analytes contained within biological samples. Examination of gold coated standards deposited on hard silicon wafers did not yield a signal enhancement, suggesting that the SIMS …
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Influence of Indole and Mixed Culture Growth on Pseudomonas Aeruginosa Biofilm Structure
… to produce N-acylated homoserine lactone (AHL) signals had altered biofilm structure. During mixed culture growth of P. aeruginosa with Escherichia coli, we found that E. coli production of the organic compound, indole, inhibited AHL-regulated genes in P. aeruginosa. The current study was …