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Showing 1 to 20 of 123 for “"quinoline"”.
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Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents
… and biological evaluation of new quinoline as well as non-quinoline based compounds. Selected Rh(I) metal complexes thereof were also studied. The compounds were screened for antiplasmodial activity, in addition, their activity against WHCO1 oesophageal cancer cells and the …
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The anticancer potential of CITme, a quinoline derivative
… prop-2-enone citrate “CITme” is a substituted quinoline derivative, synthesized as a potential antitumour agent. The aim of this study was to investigate CITme with regard to antitumour activity, toxicity and pharmacokinetics. In vitro screening for neoplastic cytotoxic effects using standard …
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Effect of Phenol on the System Quinoline Water
For ten years after the brilliant deduction of the phase rule in 1874 by Willard Gibbs at Yale the work lay buried in the archives of the Connecticut Academy of Science, undisturbed and uninterpreted. It was not until 1884 that Roozeboom of Belgium, who was working on methods of separating salts …
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Some studies of substituted pyridine and quinoline compounds
The reactions with tpioolia G with lepidSas have beci investigated 0 The conditions flewià for eztensivs thfl gflap litigation, fl 09)0504 to -the alterlu tin Ompas=thine S4itiov reaction, are dstsrmigis4 and the results are die *8004 a With leptUivt mnsazththe a"Itiog was predSisM, although …
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Enthalpy measurements of the M-cresol/quinoline binary system
Includes bibliographical references.
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Antimalarial Evaluation of Quinoline-triazoleMn(I) and Re(I) PhotoCORMs
… evaluation as antiplasmodial agents of two new quinoline-1,2,4-triazole ligands and their respective Mn(I) and Re(I) tricarbonyl complexes. The two ligands differ in the presence of an extended amino-propyl chain conjugated to the quinoline scaffold, which has proven to confer greater …
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Reaction network and kinetics of vapor-phase catalytic hydrodenitrogenation of quinoline
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1980.
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Design, synthesis and biological evaluation of novel tetra-substituted quinoline-3-carboxamides derivatives
Quinolines are well known naturally occurring heterocyclic compounds with nitrogen as a heteroatom. Quinolines are also one of the major classes of naturally occurring compounds and the interest in their chemistry is due to the wide range of their biological activities. The objective of the project …
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Interactions of quinoline antimalarials with haematin and their effect on ß-haematin formation
Thermodynamic compensation in the interaction of quinoline antimalarials with haematin in 40% (v/v) aqueous OMSO has been compared with that in pure aqueous solution. The data indicate that the degree of desolvation and loss of conformational freedom is identical in both systems. The nature of …
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Synthesis and investigation of quinoline based ß-haematin formation inhibitors as potential antimalarials
… not replacing the 7-chloro group in the 4-aminoquinoline moiety with an electron withdrawing and hydrophilic substituent results in retention of antiplasmodial activity in the 4-aminoquinoline class of compounds was investigated...
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Synthesis and evaluation of quinoline-5,8-diones and isoquinoline-5,8-diones as anticancer agents
… routes towards a nascent class of functionalised quinoline-5,8-diones and isoquinoline-5,8-diones. The structured approach adopted is predicted to lead to advancements in the two frameworks, expanding the structural diversity of both the quinoline-5,8-diones and isoquinoline-5,8-diones families …
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Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
… drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. …
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The Effect of Two Catalysts (Ammonia and Quinoline) on The Liquefaction of North Dakota Lignite
… distillate, overall conversion is not increased. Quinoline had no significant effect on the overall conversion and distillate yield, except in the presence of hydrogen at 420˚C.</p>
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Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies
… parasite strains. Two series of 7-chloroquinoline-1,2,3-triazole ligands, one with the direct attachment of the triazole to the quinoline and one where the two entities are separated by an aminopropyl linker, were synthesised. Coordination of selected ligands with [IrCl(μ-Cl)(Cp*)]₂ …
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Repurposing quinoline-based (metallo) drug leads for the treatment of Leishmania major-induced cutaneous leishmaniasis
… For instance, N-heterocyclic molecules, such as quinolines and aminoquinolines, are commonly used as privileged scaffolds for developing antimalarial and anticancer drugs, which show enhanced activity when combined with metal complexes. This is exemplified by the iron-containing compound …
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Synthesis and Physical Properties of Helical Nanosized Quinoline-based Foldamers: Structure, dynamics and photoinduced electron transport
… (photoinduced electron transport) of nanosized quinoline-based foldamers have been explored. With double segment strategy, a variety of helical nanosized foldamers (up to 96 quinoline units) were successfully prepared based on 8-aminoquinoline-2-carboxylic acid monomer. The dynamic properties in …
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Effect of hydrogen sulfide on the kinetics of hydrodenitrogenation of quinoline and its reaction intermediates in vapor phase
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 1980
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