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Showing 1 to 18 of 18 for “"quinidine"”.
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Mechanism of Inhibition of Transepithelial Sodium Transport in Frog Skin by Quinine and Quinidine (Noise Analysis, Cgs 4270, Basolateral Membrane)
… to assess the effects of quinine and quinidine on the electrophysiological characteristics of the Na('+) transporting epithelial cells of frog skin. Under control conditions with tissues bathed symmetrically with a Cl-HCO(,3) Ringer solution and short-circuited continuously, quinine …
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Pharmacological regulation of c-myc gene expression in human breast cancer cells
Previous studies demonstrated that quinidine causes G1/G0 cell cycle arrest and inhibition of proliferation in MCF-7 human breast cancer cell line (Woodfork, K. et al., 1995). The goal of studies reported here was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc …
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Antitumor activity of antimalarials in human breast cancer cells
Previously we showed that quinidine arrested MCF-7 cells in G1 phase of the cell cycle and led to a G1 to G0 transition followed by apoptotic cell death (Wang et al., 1998). The present experiments demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate …
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Effects of NMDA Receptor Antagonists on the Differential-Reinforcement-of-Low-Rate 72 Second (DRL 72) Responding in Rats
… nervous system. Dextromethorphan alone and with quinidine (a CYP-450 2D6 inhibitor) have been shown to produce antidepressant effects in preclinical and clinical trials. Sex differences and the effect of estrous cycle on differential-reinforcement-of-low-rate 72 second (DRL72) responding have yet …
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Interactions of ferriprotoporphyrin IX with neutral lipids and detergents: insights into their role in β-haematin formation
… complex. In contrast, the quinoline methanols, quinidine and quinine, strongly increased the observed lipophilicityof Fe(III)PPIX in a pH dependent manner. Quinidine was found to effect the largest increase eon Fe(III)PPIX partitioning into NLBDs which was proposed to be due to a previously …
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Synchronised capacitor discharge in the management of cardiac arrhythmias with particular reference to the haemodynamic significance of atrial systole
… resistant to treatment with procaine amide, quinidine, atropine, prostigmine, prednisone and digoxin. A second stage, total correction for tetralogy of Pallot had been successfully performed two years before by Sir Russell Brock and the tachycardia followed a sudden blow on the cheat at his …
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Interactions of quinoline antimalarials with haematin and their effect on ß-haematin formation
… of association of chloroquine, quinine and quinidine with haematin are largely insensitive to the increasing concentration of NaCI0. This demonstrates that electrostatic interactions play a minor role in the overall stability of these complexes under these conditions. Increasing …
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Amelioration of oxidative lung injury by antiarrhythmic agents
Class I antiarrhythmic drugs, such as lidocaine, quinidine and procainamide, are known to be effective membrane stabilizers. However, the mechanism of such "membrane stabilization" has not been elucidated. In the present study we found that all three drugs are powerful scavengers of hydroxyl! …
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Some observations on the refractory period of the heart
… and auricular flutter and the introduction of quinidine for their treatment, the refractory period has assumed an increasingly important ró le in understanding the pathology and the therapeutics of many disorders of cardiac contraction. A thorough knowledge of its physiology, therefore, is of …
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Insights into the mechanism of action of quinoline antimalarials against Plasmodium falciparum revealed by novel fluorescent analogues and chemical proteomics
… diastereomeric Cinchona alkaloids quinine and quinidine, and the 4-aminoquinolines, represented by chloroquine. Mechanistic studies of these antimalarials have typically focused on the inhibition of haemozoin biocrystallisation within the acidic digestive vacuole of P. falciparum. In order to …
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The Development of Asymmetric Palladium-Catalysed Transformations Using Chiral Sulfonated Phosphine Ligands
… recrystallisation of its salt with protonated quinidine. The second half of this thesis assesses the efficacy of enantiopure sSPhos in two asymmetric palladium-catalysed reactions: π-allyl nucleophilic additions and atroposelective Suzuki- Miyaura cross-couplings. For asymmetric …
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Asymmetric hydrogenation catalysed by platinum and iridium
… cinchonidine and cinchonine, or of quinine and quinidine has been performed and results obtained as to the effect on reaction rate and optical yield. The variation of the latter with the mole fraction of modifier has been fitted to a mathematical model which supports the view that the mechanism …
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The interactions of Propafenone and its enantiomers with the major human forms of cytochrome P450 in terms of inhibition and metabolic rates
… inhibitors (CYP2C19 – Tranycylpromine; CYP2D6 – Quinidine; CYP3A4 – Ketoconazole ; CYP1A2 - Furafylline). In vitro metabolism was conducted using human liver microsomes incubated with propafenone (racemate and enatiomers) and the degree of metabolism measured using hplc analysis. Protein binding …
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Effect of berberine on in vitro metabolism of sulfonylureas: a herb-drug interactions study
… and the NADPH regenerating system. Cimetidine, quinidine and ketoconazole as the inhibitors of CYP1A, CYP2D and CYP3A were used at 5 to 30 μM, 0.01 to 3 μM and 0.01 to 1.5 μM, respectively with a fixed concentration of berberine of 20 μM in presence of 0.5 microsomes and the NADPH regenerating …
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Influence of magnesium on salivary gland secretion: physiological and pathophysiological studies
… dinitrophenol (DNP) bumetanide, amiloride, quinidine or lidocaine resulted in significant (P<0.01) increases in [Mg2+]i. In the presence of these inhibitors ACh still stimulated a reduction in {Mg2+]i. Taken together, these studies on animal model have demonstrated marked interactions …
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Determining the solubility of haematin and haem-drug complexes at relevant pH in aqueous medium via spectrophotometric titration
… in this study by chloroquine (CQ) and quinidine (QD), respectively — are widely accepted to act against the most virulent malaria parasite, Plasmodium falciparum, via the haemozoin inhibition pathway within the acidic digestive vacuole (DV) of the pathogen. However, mechanistic details …
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Molecular mechanism of magnesium transport in epithelial cells
… (DNP), io M amiloride, 1 mM lidocaine or I mM quinidine there were significant (P <0.05) decreases in net Mg 2 efflux. Replacement of extracellular sodium [Na4]0 with either N -methyl-D-glucamine (NMDCI), or choline chloride resulted in a significant (P C 0.05) inhibition of Mg2 effiux. The …
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ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΧΗΜΕΙΟΦΩΤΑΥΓΕΙΑΣ ΑΠΟ ΑΝΑΓΩΓΗ ΤΕΤΡΑΣΘΕΝΟΥΣ ΔΗΜΗΤΡΙΟΥ
THIS DOCTORAL THESIS IS FOCUSED ON THE STUDY OF NEW CHEMILUMINESCENT REACTIONS WHICH OCCUR DURING REDUCTION OF TETRAVALENT CERIUM. THESE REACTIONS ARE AMONGSTTHE FEW EXAMPLES OF CHEMILUMINESCENCE REACTIONS IN ACIDIC MEDIUM. THE PROCEDURES DEVELOPED WERE SATISFACTORILY APPLIED TO THE ANALYSIS OF …