Global ETD Search
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Showing 1 to 7 of 7 for “"quinazolines"”.
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Synthesis and SAR investigation of haemozoin-inhibiting quinazolines active against Plasmodium falciparum
… selectivity indices indicated that 2,4-diaminoquinazolines were not cross-resistant with chloroquine (CQ) and possess selective activity against P. falciparum. On the negative side, they possessed poor aqueous solubility, with the majority in the ranges 5-40 μM. In terms of structure-activity …
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Defined Dimensional Changes in Purine Analogues
… elaboration of suitably substituted indazoles or quinazolines, were found to be active substrates for and alternative-substrate inhibitors of xanthine oxidase. In each case, the product of enzymatic oxidation has been isolated and compared with the same material synthesized chemically. These …
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The development and synthetic applications of Ti- and Pd-catalyzed processes
… asymmetric reduction of quinoxalines and quinazolines was developed. This complements technologies developed by others for the asymmetric reduction of other aromatic heterocycles. This chemistry utilizes a Ti catalyst based on the C2-symmetricansa-metallocene scaffold. In these studies, we …
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The Rich Chemistry of Cyclotriveratrylene (CTV) And CT-Inspired Reactions: Anthracenes with Organic Light-Emitting Diode (OLED) Applications and the Discovery of Cascade Reactions
… sequence affords pharmaceutically important quinazolines and is presently being explored for its generality with very encouraging results.</p>
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… dose limiting toxicity and multidrug resistance, quinazolines were designed and synthesized as dual acting MTA and RTK inhibitors.<br /> Toll-like receptors (TLRs) are key mediators in regulating the inflammatory response. Currently, more than 50 clinical trails of TLR agonists in the treatment of …
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Developments in Nickel-catalyzed Transfer Hydrocyanation Reactions and Novel Skeletal Editing Strategies through Nitrogen Atom Insertion
… including the transformation of indoles into quinazolines or quinoxalines, as well as pyrroles into pyrimidines, indenes into isoquinolines, or cyclopentadienes into pyridines (see Scheme II). The initial reaction design was based on the mechanistic proposal for the previously established …