Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 172 for “"quiescence"”.
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
… that chromatin becomes more accessible upon quiescence induction. Moreover, quiescent cells gain more Trithorax chromatin domains and revert to a less accessible state upon reactivation. I also showed that genes necessary for neurotransmitter-based signalling become upregulated in quiescence …
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Detection and prediction of cardiac quiescence for computed tomography coronary angiography
… data acquisition during periods of cardiac quiescence. Because the ECG is an indication of electrical activity, it is a surrogate marker of the mechanical state of the heart. Therefore, gating based on a signal derived directly from cardiac motion using either echocardiography or …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… SC function challenging. To optimally promote SC quiescence and enable exploration of SC dynamics in vitro, engineered muscle needs to recapitulate the native muscle microenvironment, which is comprised of muscle fibers, extracellular matrix, and other biochemical and mechanical cues. In disease …
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Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos
… derived from a donor cell that was induced into quiescence by serum starvation. We hypothesized that quiescence alters the epigenetic status of donor cells and elevates their reprogrammability. In order to test this idea, we compared chromatin composition and cloning efficiency of serum-starved, …
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Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution
… is still not known, in particular in humans. Quiescence is an important property of HSCs and fine regulation of the balance between quiescence and cell cycle entry is of vital importance for maintaining a healthy HSC pool and avoid haematological malignancies. Very little is known about how …
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
… HFSCs failed to remain in prolonged durations of quiescence. Instead, they were primed to re-enter the cell cycle and launch new rounds of hair regeneration prematurely. After activation, they failed to re-establish quiescence promptly, and remained in a primed state to proliferate. In turn, their …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
… between NSC proliferation, differentiation and quiescence. Studying the mechanisms that regulate this balance is important for understanding development and disease, providing a basis for new therapeutic strategies for brain injury or cancer. In Drosophila melanogaster, a small pool of NSCs …
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The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
The aging phenomena is a process to which all organisms eventually succumb. The universality of this phenomena suggests that there may be one overwhelming factor involved. The exact biochemical basis of aging is still unclear. Free radicals such as the superoxide radical (O₂⁻) and the hydroxyl …
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Exploring the Role of Long Non-Coding RNA in Neural Stem Cell Reactivation from Quiescence: A Functional Genomics Approach
… neural stem cell (NSC) reactivation from quiescence. Through doing this, ten novel quiescence-associated lncRNAs were identified. One such lncRNA, pron, was found to be strongly upregulated in reactivating NSCs compared to quiescent NSCs. pron is localised to multiple nuclear puncta, …
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Development of a reversible quiescence model to identify signals enabling glioblastoma cancer stem cell transition between active and quiescent states
… cell cycle to re-initiate tumour growth (1, 2). Quiescence is a heterogenous state with different depths, defined as ‘shallow’ and ‘deep’, depending on the rate at which cells re-enter the cell cycle (3, 4). This PhD project aims to develop a reversible GSC quiescence model using Bone …
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The Examination and Evaluation of Dynamic Ship Quiescence Prediction and Detection Methods for Application in the Ship-Helicopter Dynamic Interface
… the identification of discrete lull periods or quiescence for shipboard helicopter operations can be better defined using a landing period indicator than with the current method of utilizing static deck angle measurements. While few of these systems exist, assessing their operational benefits is …
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Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
… signals. However, the pathways that maintain HSC quiescence and maintenance during proliferative stress are not well understood. This study has investigated the role of cholinergic signals during healthy and malignant haematopoiesis. During healthy haematopoiesis, sympathetic cholinergic signals …
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Uncovering the Importance of Cell Morphology, Genetic Regulation, and Neuronal Signalling in Quiescent Neural Stem Cells
… neurons during neurogenesis. These cells undergo quiescence, the state when quiescent cells are metabolically active but do not produce new neurons. Understanding and manipulating this critical state is essential due to undiscovered applications in regenerative biology and precision medicine, …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
… Identifying novel regulators of neural stem cell quiescence will provide more molecular targets for brain regeneration therapies. Drosophila melanogaster is an excellent model for understanding NSC quiescence. The NSCs in Drosophila transit between quiescence and proliferation. The transcriptional …
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Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
… neural progeny. Understanding how NSCs balance quiescence and activation is crucial for the development of brain repair therapies. Drosophila NSCs, termed neuroblasts (NBs), are a model to study reactivation from quiescence. The Hippo and Insulin pathways were reported to promote NB quiescence …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
… non-permissive cells, termed latency in vivo or quiescence in vitro, in which minimal activity of the viral genome allows it to colonize its host. While the lytic state of viral replication is relatively well characterised, understanding of latency has lagged due to a lack of invitro models that …
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The Roles of the Neuropeptide Receptor NPR-14 in the Regulation of Sleep Behaviours in Caenorhabditis elegans
… C. elegans. The first is a developmentally timed quiescence (DTS), known as lethargus; and the second is a stress induced quiescence (SIS). Each type of sleep functions through different neuronal pathways and utilizes a variety of neuropeptide signaling molecules. The DTS pathway uses the …
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Characterisation of the Components in Cataclysmic Variables
… has been observed both in superoutburst and quiescence. Optical 'wide B' band light curves were obtained at the end of the 1994 superoutburst and on the decline. Eclipse mapping of these light curves reveals an accretion disc with a considerable physical flare (~ 10'). These are the first …
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Investigating the Morphology and Behaviour of Quiescent Neural Stem Cells in Drosophila Melanogaster
… as neuroblasts, undergo a similar period of quiescence. Neuroblasts divide during embryogenesis to generate neurons and glia for the larval nervous system. Just before hatching neuroblasts enter quiescence and cease diving. They also adopt a specific morphology in which a long primary process …
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Female Pleasure and Theories of Desire in Narrative Structure: Evolution, Futurity, and Species Survival in the Post-Human and Science Fiction Imaginary
… cultivates the overlooked liminal space of <em>quiescence</em>. This analytical framework emphasizes narrative structure over theme-based analysis to unlock the radical imagination present in the texts by highlighting the challenges of narrativizing a post-human future in <em>Battlestar …
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