Global ETD Search
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Showing 1 to 1 of 1 for “"quaternary epitope"”.
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… were found that increase presentation of quaternary epitopes associated with closed trimeric Env. Many of the mutations reduce electrostatic repulsion at the Env apex, or increase hydrophobic packing at the gp120 inner-outer domain interface. Furthermore, engineered Env variants containing …