Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"quantitative trait locus (QTL)"”.
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Genetic architecture of multiple disease resistance in one maize chromosome segment substitution line population
… practical chemical control. Thus, we conducted quantitative trait locus (QTL) mapping for BLS resistance in three maize populations: the Z022 (B73 × Oh43 recombinant inbred line) NAM population, the Z023 (B73 × Oh7B recombinant inbred line) NAM population, and the DRIL78 (NC344 × Oh7B chromosome …
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Genetic network regulating variation in vegetative phase change in maize
… Also, continuous variation of leaf identity traits in diverse genetic mapping populations indicates the feasibility to use quantitative trait locus (QTL) analyses to find underlying genes. I demonstrate here that Glossy15 (Gl15) is the most important gene controlling leaf identity traits in …
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Multiscale Genomic Analysis of the Corticolimbic System: Uncovering the Molecular and Anatomic Substrates of Anxiety-Related Behavior
… to higher-order cognitive and behavioral traits. The far-reaching impact that genes have on higher traits is apparent in several neuropsychiatric conditions such as stress and anxiety disorders. Like most, if not all, neural phenotypes, stress, anxiety, and other emotion-related traits are …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
… nociception-related gene(s), we performed quantitative trait locus (QTL) mapping studies of nociception. We found two significant QTLs, associated with chemical/inflammatory nociception, on chromosomes 9 and 10. Also featuring considerable genetically determined variability is pain …
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New statistical methods in bioinformatics: for the analysis of quantitative trait loci (QTL), microarrays, and eQTLs
… first study discusses a method for detecting a quantitative trait locus (QTL) when the trait of interest has a zero-inflated Poisson (ZIP) distribution. Though existing methods based on normality may be reasonably applied to some ZIP distributions, the characteristics of other ZIP distributions …
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Characterising the gene regulatory landscape of CD4+ T cells
… how this can lead to autoimmunity. I carried a quantitative trait locus (QTL) mapping using RNA-seq, ATAC-seq, H3K4me3 and H3K27ac ChM-seq data from Tregs isolated from 100 individuals. Additionally, I processed publicly available data from naive T cells to distinguish the Treg specific effects …
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FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats
… difficulties in the analysis of complex traits. The first part of this thesis is summarizing two major problems we have faced in the past years. In the first study we investigated the genetic setup and the response towards various arthritis models of two DA rat substrains. We detected …
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Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
… benign to highly virulent. A wide variety of traits, such as thermal tolerance, melanin production, and an extracellular capsule contribute to virulence, yet our understanding of the genetic architecture of such traits is limited. In the studies reported here, I describe the first genome-wide …
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High-throughput phenotyping and physiological genetics of stomatal patterning and water use efficiency in maize
… robust, and versatile in extracting anatomical traits for multiple cell types on the epidermis. Two years of Quantitative Trait Locus (QTL) mapping in a B73 x MS71 Recombinant Inbred Line (RIL) population for various epidermal traits identified 36 consistent QTL for a given trait in both years, …
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Analysis of Starch Branching Enzyme 1 (SBE1) Gene in Maize
<p>A previous study revealed a quantitative trait locus (QTL) in maize on the short arm of chromosome 5 (5S) for endosperm amylose content. In that original study, both low and high amylose parental lines, H99ae and GEMS-0067 respectively, were homozygous recessive for <em>amylose extender 1 …
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Genetic dissection of essential hypertension and familial intracranial aneurysm
… chromosome 5q31.1-qter to blood pressure as a quantitative trait, and hypertension as a qualitative trait. This distal region of chromosome 5 was focused upon due to its implication by other human and animal model studies and the cluster of cardiovascular candidate genes located there. Eleven …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… manner (neuroprotection), we used quantitative trait locus (QTL) mapping on mouse strains that exhibit the most difference in infarct volumes but the least difference in collateral numbers (C57BL/6J and C3H/HeJ). From the F2 B6 x C3H cross, we mapped 4 loci determining infarct …
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Investigations on the influence of CO2 on leaf epidermal development in Arabidopsis thaliana
… plant life cycle and the genetic basis of these traits has been explored by quantitative trait locus (QTL) mapping of an Arabidopsis recombinant inbred (RI) population. In order to quantitatively characterize thousands of Arabidopsis leaf epidermis samples, a new method for high-throughput …
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Variation and quantitative trait loci analysis of myrosinase activity and phenolic compound accumulation in Brassica oleracea var. italica
Made available in DSpace on 2016-03-02T20:24:12Z (GMT). No. of bitstreams: 2 GARDNER-THESIS-2015.pdf: 3191246 bytes, checksum: 282a4f72b0a6003e1ab58dc6ded758c2 (MD5) LICENSE.txt: 4211 bytes, checksum: 9b8349680069b41d9e16d0ea2a47d366 (MD5) Previous issue date: 2015-12-04
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Evaluation and characterization of QTL controlling seed composition in soybean and breeding for resistance to sudden death syndrome of soybean
The first quantitative trait locus (QTL) mapping study in soybean (Glycine max) was published over twenty years ago. Since then numerous QTL mapping studies have been performed for most traits of economic interest within the soybean research community. Though many putative QTL regions have been …
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Preliminary quantitative trait loci analysis for biomass traits in Miscanthus sinensis
… of progeny. Establishing correlations between traits exhibited during the establishment phase and plot yields and developing a marker assisted selection program would allow earlier selection. With this in mind, a QTL study was conducted in a pseudo testcross mapping population segregating for …
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The generation and maintenance of diversity in a rapid adaptive radiation
… of jaw morphology and a complex functional jaw trait. We use a complex biomechanical system, the 4-bar jaw linkage, to simulate trait evolution during interspecific hybridizations. We find rampant transgression (trait values beyond parental distributions) in jaw function in a large proportion of …
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The Genetic Architecture of Juvenile Migration in Rainbow Trout (Oncorhynchus mykiss)
… modulating this adaptive tactic. Using quantitative and molecular genetic techniques I describe the genetic basis of the marine migratory life history in three focused research chapters.</p> <p>In the first I conduct a quantitative trait locus (QTL) analysis, using an experimental cross, …
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Genes, haplotypes and physiological traits associated with a chromosome 3B locus for wheat improvement in hot climates
… we focussed on the positional cloning of a quantitative trait locus (QTL), qYDH.3BL, located on the wheat chromosome arm 3BL. The QTL has been identified by the multi-environment analysis of the double-haploid (DH) population of the cross from the drought tolerant line RAC875 and the …
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Uncovering the genetic basis of seed amino acid composition in arabidopsis using a multi-omics integrative approach
… I validate observations from GWAS using both a quantitative trait locus (QTL) analysis and reverse genetic approaches to identify a unique, seed-specific Glutamine-glucosinolate relationship that alters nitrogen and sulfur homeostasis in the seed in the Arabidopsis 360 population. Such finds …
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