Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"quantitative trait locus"”.
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Quantitative Trait Locus Analysis of Iron Deficiency Chlorosis in Soybean
… population for genetic variability of the IDC trait and its relationship with plant iron (Fe) content, and 2) to generate a linkage map covering the wild soybean genome to map quantitative trait loci (QTL) associated with the IDC trait. A total of 207 RILs were grown in the same field (soil pH …
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Quantitative trait locus mapping of yield and yield components in canola (Brassica napus L.) under irrigated and rainfed treatments
… among yield and yield components by analyzing trait correlations and to study trait inheritance patterns; 3) to determine areas of the B. napus genome that are implicated in yield and yield component traits under both rainfed and irrigated conditions by quantitative trait locus (QTL) analysis; …
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Using single-cell RNA-seq to assess the effect of common genetic variants on gene expression during development
… of DNA variants associated with complex traits and diseases, by exploiting naturally occurring genetic variation in large populations of individuals. More recently, similar approaches have been applied to RNA sequencing (RNA-seq) data to find variants associated with expression level, …
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Genetic architecture of multiple disease resistance in one maize chromosome segment substitution line population
… practical chemical control. Thus, we conducted quantitative trait locus (QTL) mapping for BLS resistance in three maize populations: the Z022 (B73 × Oh43 recombinant inbred line) NAM population, the Z023 (B73 × Oh7B recombinant inbred line) NAM population, and the DRIL78 (NC344 × Oh7B chromosome …
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Genetic network regulating variation in vegetative phase change in maize
… Also, continuous variation of leaf identity traits in diverse genetic mapping populations indicates the feasibility to use quantitative trait locus (QTL) analyses to find underlying genes. I demonstrate here that Glossy15 (Gl15) is the most important gene controlling leaf identity traits in …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… contextual fear memory in C57BL/6J by using quantitative trait locus analysis. In the third component (Chapter 4), I found a change in GABAB receptor-mediated feedforward inhibition led to distinct hippocampal responses to environmental stimuli. This difference further led to distinct …
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Multiscale Genomic Analysis of the Corticolimbic System: Uncovering the Molecular and Anatomic Substrates of Anxiety-Related Behavior
… to higher-order cognitive and behavioral traits. The far-reaching impact that genes have on higher traits is apparent in several neuropsychiatric conditions such as stress and anxiety disorders. Like most, if not all, neural phenotypes, stress, anxiety, and other emotion-related traits are …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
… nociception-related gene(s), we performed quantitative trait locus (QTL) mapping studies of nociception. We found two significant QTLs, associated with chemical/inflammatory nociception, on chromosomes 9 and 10. Also featuring considerable genetically determined variability is pain …
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Mapping Genotype to Phenotype with High-Throughput Empirical Approaches
… adapting under natural selection, and quantitative understanding will be required to predict and engineer outcomes in evolving organisms like viral pathogens, cancer cells, or microbial communities. Characterizing the landscape structure remains largely an empirical question, and …
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EXAMINING THE GENETIC BASIS AND PHYSIOLOGY OF SURVIVAL IN EXTREME LOW SALINITY TO IMPROVE AQUACULTURE OF THE EASTERN OYSTER Crassostrea virginica
… low salinity (2.5) challenges to estimate the quantitative genetic parameters of low salinity survival. A moderate narrow-sense heritability was estimated for challenge survival, h2 ≈ 0.4. In addition, osmolality of hemolymph collected from oysters during the first week of the challenge suggest …
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The Role of Mitochondria in the Development of Insulin Resistance and Type 2 Diabetes
… is a regulatory element (an expression quantitative trait locus) located at intron 26 in ABCC5.<br/>The third component of this thesis is a comprehensive investigation into the potential role of nuclear-encoded mitochondrial (NEM) genes in the aetiology of T2D. A pathway analysis …
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New statistical methods in bioinformatics: for the analysis of quantitative trait loci (QTL), microarrays, and eQTLs
… first study discusses a method for detecting a quantitative trait locus (QTL) when the trait of interest has a zero-inflated Poisson (ZIP) distribution. Though existing methods based on normality may be reasonably applied to some ZIP distributions, the characteristics of other ZIP distributions …
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Understanding the role of CD4+ T cells in common immune-mediated diseases
… diseases such as autoimmunity are complex traits which collectively affect around 10% of the European population. Genome-wide association studies (GWAS) have demonstrated that genetic susceptibility to these diseases is explained by thousands of loci spread throughout the genome, most of …
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Identificação e caracterização de genes de Herbaspirillum necessários para interação patogênica e não-patogênica com gramíneas e identificação de genes de Sorghum bicolor envolvidos na resistência a doença da estria vermelha
… da doença, técnicas de RNA-seq e QTL (Quantitative trait locus) foram aplicadas em genótipos de sorgo com o objetivo de identificar fatores, presentes na planta, potencialmente envolvidos com a interação entre H. rubrisubalbicans e Sorgo. Dentre os resultados obtidos, genes envolvidos …
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Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans
… study IV, we performed a genome-wide methylation quantitative trait locus (mQTL) analysis to assess the effects of SNPs on DNA methylation in human pancreatic islets. Our results demonstrate that DNA methylation in pancreatic islets is under the control of genetic variability, suggesting the …
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Characterising the gene regulatory landscape of CD4+ T cells
… how this can lead to autoimmunity. I carried a quantitative trait locus (QTL) mapping using RNA-seq, ATAC-seq, H3K4me3 and H3K27ac ChM-seq data from Tregs isolated from 100 individuals. Additionally, I processed publicly available data from naive T cells to distinguish the Treg specific effects …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… Sleep mice, as well as congenics for the Lore5 quantitative trait locus, also demonstrated an inverse relationship between MAGE and duration of LORR. The hypothesis was further investigated using cuprizone to model demyelination in B6 mice and test them in a battery of acute ethanol behaviors. …
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FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats
… difficulties in the analysis of complex traits. The first part of this thesis is summarizing two major problems we have faced in the past years. In the first study we investigated the genetic setup and the response towards various arthritis models of two DA rat substrains. We detected …
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Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
… benign to highly virulent. A wide variety of traits, such as thermal tolerance, melanin production, and an extracellular capsule contribute to virulence, yet our understanding of the genetic architecture of such traits is limited. In the studies reported here, I describe the first genome-wide …
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