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Showing 1 to 20 of 60 for “"pyruvate dehydrogenase"”.
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Pyruvate dehydrogenase activity in response to skeletal muscle contraction at two stimulation frequencies in pyruvate dehydrogenase kinase 2 knockout mice
Pyruvate dehydrogenase (PDH) plays an important role in regulating carbohydrate oxidation in skeletal muscle. PD H is deactivated by a set of PD H kinases (PD K 1-4) with PDK2 and 4 being the predominant isoforms in skeletal muscle. PDK2 is highly sensitive to pyruvate inhibition, and is the most …
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The Role of Pyruvate Dehydrogenase in Cell Growth
… glucose oxidation, indicating activity of pyruvate dehydrognase (PDH), which gates entry of glucose derived carbon into the tricarboxylic acid (TCA) cycle. To test whether cells require glucose oxidation for proliferation, the work in this thesis establishes a model wherein PDH activity is …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
The human pyruvate dehydrogenase multi-enzyme complex (PDC) catalyses the oxidative decarboxylation of pyruvate, transferring the resultant acetyl group to coenzyme A. It belongs to the family of 2-oxoacid dehydrogenase complexes that includes the 2-oxoglutarate dehydrogenase (OGDC) and …
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Studies on the pyruvate dehydrogenase phosphatase and 3-hydroxyisobutyryl-CoA hydrolase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
The expression of pyruvate dehydrogenase kinase (PDK) 2 and 4 are increased in the fasted state to inactivate the pyruvate dehydrogenase complex (PDC) by phosphorylation to conserve substrates for glucose production. To assess the importance of PDK2 and PDK4 in regulation of the PDC to maintain …
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Cell-Type Specific Requirement for Pyruvate Dehydrogenase in Hematopoiesis and Leukemia Development
Pages i-xii are misnumbered as pages ii-xiii, and page 142 is misnumbered as page 121.
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Phosphorylation of Skeletal Muscle Pyruvate Dehydrogenase Phosphatase in Response to Insulin Stimulation
Pyruvate dehydrogenase phosphatase (PDP) regulates carbohydrate oxidation through the pyruvate dehydrogenase (PDH) complex. PDP activates PDH, enabling increased carbohydrate flux towards oxidative energy production. In culture myoblasts, both PDP1 and PDP2 undergo covalent activation in response …
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Structure and Molecular Biology of the Pyruvate Dehydrogenase Complex from Bacillus stearothermophilus
The pyruvate dehydrogenase multienzyme complex (PDHC) from the thennophilic, Gram-positive bacterium Bacillus stearothermophilus is assembled around a core of 60 copies of the dihydrolipoamide acetyltransferase (E2p) component, organized with icosahedral symmetry. The peripheral subunits, attached …
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Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex
Call number: LD2668 .T4 1985 J54
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Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex
Call number: LD2668 .T4 1985 J54
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Analysis of genetic mutations using a recombinant model of the mammalian pyruvate dehydrogenase complex
The human mitochondrial pyruvate dehydrogenase complex (PDC) is a vital metabolic assembly that controls the key committed step in aerobic carbohydrate utilisation and energy production and as such is responsible for overall glucose homeostasis in man. PDC, particularly from prokaryotic sources, …
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Adaptations of skeletal muscle pyruvate dehydrogenase kinase in response to food-restriction in mitochondrial subpopulations
University, 2006 Dr. Sandra J. Peters Pyruvate dehydrogenase (PDH) catalyses the decarboxylation of pyruvate, to form acetyl-CoA. PDH activity is down-regulated by intrinsic PDH kinases (predominantly PDK2 and PDK4 isoforms), but the understanding of the PDK isoform distribution and adaptation to …
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The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase
… lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 ± 0.024 min"^ vs. 0.137 ± 0.023 min'\ n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 ± 0.13 mmol-min'kg'^ vs. 0.82 ± 0.32 …
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Dichloroacetate, a inhibitor of pyruvate dehydrogenase kinase-1, attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer cells
… of hypoxia-inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase-1 (PDK-1) were analyzed in tissues from 10 patients with gastric cancer who had different responses to adjuvant 5-FU treatment. For the in vitro assays, cell viability and apoptosis were evaluated with and without …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
<p>Pyruvate dehydrogenase kinase 4 (PDK4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). The PDC catalyzes the conversion of pyruvate to acetyl-CoA and it is an important control point in glucose and pyruvate metabolism. Previous …
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Characterization of an assay of insulin mediator activity on pyruvate dehydrogenase in liver tissue and its application in the study of the insulin resistant obese Zucker rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Metabolic flux analysis of Escherichia coli MG1655 under octanoic acid (C8) stress
… acid (TCA) cycle, pentose phosphate pathway, pyruvate node, alpha-ketoglutarate node and oxaloacetate node changed. By comparing the metabolic flux maps of E. coli MG1655 grown at different conditions, pathways that have flux change under stress were identified. Inhibition effect for several …
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Metabolic downregulation during diapause in embryos of Artemia franciscana
… during diapause, namely trehalase, hexokinase, pyruvate kinase and pyruvate dehydrogenase. Trehalose is the sole source of fuel in the embryos of <i>A. franciscana</i>, and hence downregulation of trehalose catabolism results in severe limitation of metabolic fuel available to the embryo during …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) or low (LWS) juvenile body weight. We hypothesized that …
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