"pyrroloindoline" · 5 results · Global ETD Search

Trichloroacetimidates as Alkylating Reagents and Their Application in the Synthesis of Pyrroloindoline Natural Products and Synthesis of Small Molecule Inhibitors of Src Homology 2 Domain- Containing Inositol Phosphatase (SHIP)

Adhikari, Arijit Anand

… of these reagents in the synthesis of pyrroloindoline based natural products, 3,3'-disubstituted indolenines and benzylic trichloroacetamides. Initial investigations on the utilization of the reactivity of trichloroacetimidates found that diphenylmethyl trichloroacetimidate, …

syracuse-diss Repository record for Trichloroacetimidates as Alkylating Reagents and Their Application in the Synthesis of Pyrroloindoline Natural Products and Synthesis of Small Molecule Inhibitors of Src Homology 2 Domain- Containing Inositol Phosphatase (SHIP) (opens in a new tab)

Trichloroacetimidates as Alkylating Reagents in C-N Bond Formation and Synthesis of Aminosteroid and Quinoline Inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP)

Wallach, Daniel Ryan

… proceeds through an SN1 type mechanism. Pyrroloindoline trichloroacetimidates may react with amine nucleophiles in the presence of catalytic BF3ˑOEt2 to generate pyrroloindoline systems decorated with amines at the C3a position. The natural product kapakahine C is a complex heterocyclic …

syracuse-diss Repository record for Trichloroacetimidates as Alkylating Reagents in C-N Bond Formation and Synthesis of Aminosteroid and Quinoline Inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) (opens in a new tab)

Formation of Pyrroloindolines and Alkylation of N-heterocycles With Trichloroacetimidates and Synthesis of Quinoline Based Small Molecule Inhibitors of Ghrelin O-acyltransferase (goat)

Joshi, Bhaskar

Pyrroloindolines and related systems are present in a large number of complex natural products. These core structures have generated considerable synthetic interest, as many of the compounds possess challenging, elaborate structures and interesting biological properties. Recently we have focused …

syracuse-diss Repository record for Formation of Pyrroloindolines and Alkylation of N-heterocycles With Trichloroacetimidates and Synthesis of Quinoline Based Small Molecule Inhibitors of Ghrelin O-acyltransferase (goat) (opens in a new tab)

Reactions for rapid access to C3a oxygenated pyrroloindolines and its application towards a novel route to pestalazine A

Mahajani, Nivedita

… containing a hexahydropyrrolo[2,3-b] indole (pyrroloindoline) core constitute a sizeable group of natural products. In these systems the most common functionality at the C3a position is perhaps the hydroxyl group. In this work oxoammonium salt 4-acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium …

syracuse-diss Repository record for Reactions for rapid access to C3a oxygenated pyrroloindolines and its application towards a novel route to pestalazine A (opens in a new tab)

A Modular Approach to Highly Functionalized Indole Derivatives and Syntheses of Tryptamine-based SHIP Inhibitors

Shah, Jigisha

Indole scaffolds are incorporated in a plethora of clinically useful natural products like ergotamine, reserpine, vincristine. Indole alkaloids have been fascinating chemists and biologists alike because of its diverse biological activity and intrinsic structural complexity. N-alkylated …

syracuse-diss Repository record for A Modular Approach to Highly Functionalized Indole Derivatives and Syntheses of Tryptamine-based SHIP Inhibitors (opens in a new tab)