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Showing 1 to 20 of 73 for “"pyrrolidine"”.
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The chemistry of some derivatives of pyrrolidine green and pyrrolidine violet
… scheme for the acidic and basic hydrolysis of Pyrrolidine Green is advanced and the associated equilibrium constants have been calculated. The rate data obtained for some substituted Pyrrolidine·Greens have been used to test the applicability of an isokinetic relationship in the TPM system. The …
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The synthesis and properties of 4-substituted pyrrolidine-2,3-Diones
… with which may form quinoxalines. A 4-carbethoxypyrrolidine -2,-3-dione will react with o-phenylenediamine win two ways forming wither a quinoxaline type structure or a diazacycloheptadiene ring. Structures are assigned to these compounds on analytical and spectral evidence and the conditions for …
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Alpha-lithioamine synthetic equivalents from N-Boc secondary amines: Piperideine, pyrrolidine, and perhydroazepine
… unactivated cyclic secondary amines; piperidine, pyrrolidine, and perhydroazepine to provide $\alpha$-lithioamine synthetic equivalents. The Boc group can be easily introduced on the nitrogen, stable to strong alkyllithium bases, and easily cleaved after elaborations. Determination of the …
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One-Pot catalysis and multicomponent cascade reactions for the stereoselective synthesis of Pyrrolidine and indole derivatives
En esta memoria se encuentran recogidos los resultados referidos al estudio de nuevos procesos multicatalíticos en cascada "one-pot" y procesos multicomponente para la síntesis de compuestos heterocíclicos. Esta memoria se ha dividido en dos capítulos. En el Capítulo 1, se describen nuevas síntesis …
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New lithiation methodologies to 2-substituted nitrogen heterocycles
… spectroscopy to monitor the lithiation of N-Boc pyrrolidine, N-Boc piperidine, N-Boc homopiperidine, an N-Boc acetal piperidine, N-Boc-Nʹ-benzyl piperazine, N-Boc-Nʹ-i-Pr imidazolidine and an O-alkyl carbamate in diethyl ether using s-BuLi and the diamines TMEDA, (–)-sparteine, or the …
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Synthesis of Amphibian Alkaloids and Synthesis and Affinity of Novel Cannabinoid Receptor Ligands
… of amphibian alkaloids is the 2,5-disubstituted pyrrolidine-based family of compounds. There are many synthetic approaches for the preparation of the trans-2,5- disubstituted pyrrolidines, but methods for the construction of the cis-2,5-pyrrolidines are limited. Therefore, it was desired to …
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Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine
… 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of …
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Diastereoselective aza-cope rearrangement-mannich cyclizations of conformationally mobile iminium cations
… Mannich cyclization (ACM) to form acyl pyrrolidines from conformationally mobile substrates. Earlier studies from our lab have shown that substituted acyl pyrrolidines can be synthesized with diastereoselectivity of 50:1 <em>trans</em> to <em>cis</em>, and that unsubstituted pyrrolidines …
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Synthetic and spectroscopic studies of 6-substituted chromone derivatives
… l-[(6-bromochromon-2-yl)-carbonyl]-pyrrolidine, 1-[(6-chlorochromon-2-yl) carbonyl]-pyrrolidine, l-[(6-methoxychromon-2-y1)-carbony1]-pyrrolidine, l-[(6-bromochromo- 2-yl)-carbonyl]-morpholine were also synthesized. The Suzuki cross-coupling reaction was also utilized, inserting a …
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Asymmetric synthesis of amines and amine derivatives: I. The cerium-mediated diastereoselective addition of organometallic reagents to chiral pyrrolidine hydrazones. II. The enantioselective addition of organolithium reagents to imines and hydrazones
Two conceptually different approaches to the asymmetric synthesis of amines and amine derivatives via the addition of organometallic reagents to the carbon-nitrogen double bond of azomethines has been investigated.
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Asymmetric Allylation of Aldehydes Catalyzed by Formamide Organocatalysts. Studies Towards The Synthesis of L- Domoic Acid Side Chain
… to the family of kainoids which possess a common pyrrolidine ring with three contiguous stereocenters. There have been multiple total syntheses of kainic acid, but only one synthesis of domoic acid reported. The structure of kainic acid and domoic acid diverts at the C-4 side chain of the …
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Asymmetric Synthesis of Homotropinone and Tropane Alkaloids using Enantiopure Sulfinimines and the Synthesis and Applications of Methanoprolines
… study a sulfinimine-derived α,ß-unsaturated pyrrolidine nitrone was utilized in the development of a Lewis acid catalyzed [3+2] nitrone cycloaddition reaction for the asymmetric synthesis of the tropane alkaloid (+)-cocaine. The masked oxo sulfinimine was treated with an excess of the sodium …
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Experimental Studies on Solvent Screening and Performance Analysis for Bitumen Recovery Using ES-SAGD
… Ether (DME), Natural Gas Condensate, Urea, and Pyrrolidine —to identify optimal concentrations that maximize recovery, minimize SOR, and reduce energy consumption. A series of ES-SAGD experiments was conducted using a fast-screening apparatus under controlled reservoir conditions (220 °C and …
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Engineering of an efficient and enantioselective biocatalyst for the preparation of chiral pharmaceutical intermediates
… is the enzymatic hydroxylation of N-benzyl pyrrolidine to its corresponding (R)- and (S)-N-benzyl-3-hydroxypyrrolidines which are important pharmaceutical intermediates. In this thesis, a two-enzyme-based colorimetric high-throughput ee screening assay and a mass spectrometry-based …
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Development of new GABA uptake inhibitors derived from proline or from pyrrolidin-2-yl acetic acid
… inhibitors for GAT-1 as well as for GAT-3. Pyrrolidine-2-acetic acid derivatives with the three N-substituents 24a-c (Scheme 54) also showed a highly potent inhibition at GAT-1 and GAT-3, respectively. My intention was to investigate how the potency of pyrrolindine-2-carboxylic acid …
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Rhodium(II)-Stabilized Vinylcarbenes: Synthetic Applications in Ylide, Cyclopropanation, and C-H Insertion Reactions
… of the cascade reaction are complex bicyclic pyrrolidines. An evaluation of reaction conditions for the formation of bicyclic pyrrolidine determined that slow addition of two equivalents of methyl trans-styryldiazoacetate to a refluxing dichloromethane solution of benzylideneaniline and 1 mol% …
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Synthesis of Amphibian Alkaloids and Development of Acetaminophen Analogues
… system in 69-72% yield. A cis-2, 5-disubstitued pyrrolidine building block derived from (-)-Cocaine•HCl was prepared. We utilized this compound as a chiral building block for the formal synthesis of (+)-gephyrotoxin. Using this pyrrolidine building block, Kishi's intermediate was obtained …
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