Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"pyroptosis"”.
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… polarization and the activation of pyroptosis via the NLRP3 inflammasome. While the role of the canonical pyroptosis pathway has been studied in NAFLD, the role of the newly discovered noncanonical (caspase-11/-Gasdermin-Ddependent) pathway has not been defined. Diet-induced NAFLD …
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
… are permissive to OROV infection and undergo pyroptosis through the activation of caspases-1, -3, and -8, leading to the cleavage of Gasdermin D (GSDMD) and Gasdermin E (GSDME), and the release of IL-1β. Furthermore, NLRP3-deficient macrophages fail to activate caspases, cleave Gasdermins, or …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… the maturation and secretion of IL-1β and IL-18. Pyroptosis, an inflammatory mode of lytic programmed cell death, is essential for host defence and other danger signals. Eh activates caspase-4/1 in macrophage that cleaved GSDMD, the executioner of cell pyroptosis, leading to the insertion of …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… leading to cleavage of pro-IL-1β/pro-IL-18, and pyroptosis, a pro-inflammatory cell death program. Although microbial recognition by Toll-like receptors (TLR) induces synthesis of pro-IL-1β and pro-IL-18, its role in inflammasome activation is insufficiently understood. In this dissertation, we …
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Rodent inflammasome activation by Toxoplasma gondii
… of Toxoplasma. A form of cell death, termed pyroptosis, can accompany inflammasome activation. The NLRP3 inflammasome is activated in mouse macrophages, leading to the secretion of IL-1[beta] in vitro. The NLRP1 and NLRP3 inflammasomes play a major role in mouse survival and control of …
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Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… been identified to play a central role in pyroptosis of monocytes, through its N-terminal effector domain cleaved by activated inflammatory caspases to form pores on cell membrane. However, as the universally expressed protein in cancer cells, its function beyond pyroptosis, the pyroptotic …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
… classical forms of necroptosis, apoptosis nor pyroptosis. Evidence was however found for active caspase-3, gasdermin E-mediated pyroptosis in one cancer cell line. Several vaccinia genes have been shown to function in blocking different host cell death pathways. We identified another inhibitor …
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STRUCTURAL AND FUNCTIONAL DETERMINANTS OF CASPASE-11 INFLAMMASOME ASSEMBLY DURING INNATE IMMUNE DEFENSE
… autoprocessing and become activated to mediate pyroptosis. Casp11 inflammasome assembly contributes to anti-microbial host defense but causes sepsis in murine models when dysregulated. To better understand noncanonical inflammasome dynamics within cells, we tracked LPS-inducible assembly of …
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The Activation of the Inflammasome during Rickettsial Infection
… the secretion of IL-1β, IL-18, and induction of pyroptosis. Specific Aim 1 focuses on the role of caspase-11-dependent inflammasome activation in host response against rickettsial infection and the activation mechanisms involved. The hypothesis of this aim is that caspase-11 is likely not …
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The role of PLK1 in NLRP3 inflammasome activation
… cytokines (IL-1 and IL-18) release and pyroptosis, an inflammasome-specific form of cell death. The kinase PLK1 plays an important and well-characterised role in mitosis, but the function of this protein in interphase has been poorly studied so far. I showed that mitosis and NLRP3 …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… to caspase-1 activation and caspase-1-dependent pyroptosis and release of cytokines IL-1 and IL-18. Mutations in AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. We found that AIM2-deficient mice were hypersusceptible to …
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Determining the Innate and Adaptive Immune Responses to Vesicular Stomatitis Virus Vaccine Vectors
… and an inflammatory form of cell death called pyroptosis that were not induced by control vectors. Flagellin signalling was determined to be through the sensor, NLRC4. Previous studies have shown that expression of flagellin enhanced the antibody response in murine in vivo models. My …
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Characterization of GSDMD as a Positive Regulator of Breast Cancer Cell Proliferation and Mammary Tumorigenesis
… lytic form of programmed cell death, known as pyroptosis. Recently, GSDM dysregulation has been implicated in a variety of cancers. Interestingly, GSDMD, the most well-characterized member, has been reportedly overexpressed in BC. However, its role in tumorigenesis and underlying molecular …
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Sex-influenced histopathological changes and the immunity during Toxoplasma gondii infection
… pathway, T cell exhaustion and apoptosis/pyroptosis. Consistent with these observations, female mice developed greater levels of DNA fragmentation as determined by TUNNEL and increased expression of NLRP3 in their brains. Overall, the results suggest that female mice mount a stronger …
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Novel detection and evasion mechanisms pertinent to immunity against Salmonella Typhimurium
… is the induction of cell death, for example by pyroptosis. Cell death destroys the bacteria’s replicative niche and exposes them to the extracellular space where they may be phagocytosed. I hypothesised that host cells might tag cytoplasmic bacteria with intracellular opsonins to assist in their …
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The Role of NLPR3 Inflammasome in Response to Thermal Injury and Sepsis
… neutrophil infiltration, ER stress, apoptosis/pyroptosis, and increased systemic inflammation. Differential effects were found in other organs with an overall faster return to baseline in inflammatory mediators. In septic burn patients, we found peaks in WAT NLRP3 gene expression occurring …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… D, leading to inflammatory cell death called pyroptosis. As E-vapour has been shown to have pro-inflammatory effects on pulmonary cells, it is possible that vapours or vapour components could lead to inflammasome activation.<br/><br/>The hypothesis of this thesis was that E-vapour induces …
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
… and then cleaved to initiate caspase-1 dependent pyroptosis and the release of pro-inflammatory cytokines. Previous structural studies have shown mechanistic models of the signalling components involved. However, the structure of the innate signalling complex has not been studied in cells so far. …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… and promoting a type of cell death called pyroptosis. Saturated fatty acids (SFAs) are known to activate the NLRP3 inflammasome but the intracellular pathways by which this activation occurs are incompletely described. I hypothesized that SFAs activate the NLRP3 inflammasome through …
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Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… of vii increased levels of γH2AX levels, and pyroptosis, in terms of increased levels of cleaved gasdermin E. Importantly, in both mouse and human HPV+ cancer cell lines treatment with alisertib, relative to vehicle control, resulted in significantly higher cell surface expression of …
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