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Showing 1 to 8 of 8 for “"pyrimidine metabolism"”.
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Aspects of purine and pyrimidine metabolism
… aspects of erythrocyte membrane transport and metabolism, and purine and pyrimidine metabolism is presented. The effects of pH, pO₂ and inorganic phosphate (Pi) on the uptake and metabolism of hypoxanthine by erythrocytes has been studied in Chapter 2. Uptake of hypoxanthine and accumulation of …
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Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
… reservoir. A better understanding of parasite metabolism is necessary to address these issues in treatment and vector control. T. brucei generates nucleic acids and nucleotide sugars through two pathways: pyrimidine salvage or de novo synthesis using glutamine. However, T. brucei lacks several …
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The regulatory roles of PyrR and Crc in pyrimidine metabolism in Pseudomonas aeruginosa
The regulatory gene for pyrimidine biosynthesis has been identified and designated pyrR. The pyrR gene product was purified to homogeneity and found to have a monomeric molecular mass of 19 kDa. The pyrR gene is located directly upstream of the pyrBC' genes in the pyrRBC' operon. Insertional …
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Purine and pyrimidine metabolism in lymphoid cells of man and some other mammalian species
Contains fulltext : mmubn000001_027071189.pdf (Publisher’s version ) (Open Access)
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Structure-Function Studies on Aspartate Transcarbamoylase and Regulation of Pyrimidine Biosynthesis by a Positive Activator Protein, PyrR in Pseudomonas putida
The regulation of pyrimidine biosynthesis was studied in Pseudomonas putida. The biosynthetic and salvage pathways provide pyrimidine nucleotides for RNA, DNA, cell membrane and cell wall biosynthesis. Pyrimidine metabolism is intensely studied because many of its enzymes are targets for …
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The Pro-Apoptotic Function of CED-9 Requires a CED-9-CED-4 Interaction
… found that RNAi against genes that affect either pyrimidine metabolism (pyr-1) or purine metabolism (gmpr-1 and adss-1) similarly allows ABplpappap to survive but that RNAi against R151.2, which affects both purine and pyrimidine metabolism, does not. gmpr-1(n6457) is suppressed by RNAi against …
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Comparative biochemistry and genetic analysis of nucleoside hydrolase in Escherichia coli, Pseudomonas aeruginosa, and Pseudomonas fluorescens.
The pyrimidine salvage enzyme, nucleoside hydrolase, is catalyzes the irreversible hydrolysis of nucleosides into the free nucleic acid base and D-ribose. Nucleoside hydrolases have varying degrees of specificity towards purine and pyrimidine nucleosides. In E. coli, three genes were found that …
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Nuclear PTEN Regulates Thymidylate Biosynthesis and Cellular Sensitivity to Antifolate Treatment
… a variety of biological processes, including metabolism, by acting on distinct molecular targets in different subcellular compartments. In the cytoplasm, PTEN regulates a plethora of metabolic processes through antagonizing the PI3K/AKT/mTORC1 pathway. However, the metabolic regulation of PTEN …