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Showing 1 to 20 of 199 for “"pyrimidine"”.
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Studies in pyrimidine chemistry.
… synthesis of a series of 2-chloro-5-(hetero)arylpyrimidines and 5-(hetero)arylpyrimidines has been investigated. The aryl substituted pyrimidines are readily obtainable from [3-(dimethylamino)-2-aryl allylidene] dimethylammonium perchlorates whilst the heteroaryl substituted pyrimidines are best …
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Pyrimidine Genes in Pseudomonas Species
… studies. It also serves as a reference for pyrimidine gene arrangements in P. aeruginosa. The second part compares the physical, and genetic maps of P. aeruginosa PAO1 with the genome sequence. The final section compares pyrimidine gene arrangements in three species of Pseudomonas. …
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Stereochemically Controlled Photoreactions of Pyrimidine Bases
Made available in DSpace on 2014-12-10T23:01:41Z (GMT). No. of bitstreams: 1 7411995.pdf: 3486377 bytes, checksum: 2505a4fec5b11d2c279aed3c0067f67a (MD5) Previous issue date: 1973
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Aspects of purine and pyrimidine metabolism
… transport and metabolism, and purine and pyrimidine metabolism is presented. The effects of pH, pO₂ and inorganic phosphate (Pi) on the uptake and metabolism of hypoxanthine by erythrocytes has been studied in Chapter 2. Uptake of hypoxanthine and accumulation of inosine 5'-monophosphate …
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Direct synthesis of pyridine and pyrimidine derivatives
… azaheterocycles. II. Single-Step Synthesis of Pyrimidine Derivatives. The single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyrimidine and quinazoline derivatives, respectively, is described. The process involves amide activation with 2-chloropyridine and …
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
… Our work has examined the significance of pyrimidine nucleotide carrier 1 (PNC1), an Insulin like Growth Factor 1 (IGF- 1)-inducible mitochondrial Uridine-5'-triphosphate (UTP) transporter in cancer. Loss of PNC1 is lethal, while suppression of PNC1 in cancer cells has been demonstrated to …
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Transcriptional regulation of the Bacillus subtilis pyrimidine biosynthetic operon
… encoding all of the 6 enzymes for de novo pyrimidine biosynthesis. Transcription is controlled by the availability of pyrimidines via a PryR-mediated attenuation mechanism at 3 attenuators within the operon, which are located in the 5$\sp\prime$ leader, the pyrP-pyrP intercistronic, and the …
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Nitrogen-14 Nuclear Quadrupole Resonance Studies of Pyrimidine and Purine Derivatives
The classical and quantum mechanical descriptions of nuclear quadrupole resonance (nqr) are reviewed. Fundamental principles of nuclear spin thermodynamics are introduced to explain double resonance via level crossing (drlc), the experimental technique employed to detect ('14)N nqr resonances.
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Equilibrium Dialysis Studies of Purine and Pyrimidine Binding to Rabbit Myofibrils
Made available in DSpace on 2014-12-05T20:55:38Z (GMT). No. of bitstreams: 1 5805447.pdf: 2201465 bytes, checksum: af98da1dc92c66e90077493b47db502e (MD5) Previous issue date: 1958
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Autogenous transcriptional attenuation of de novo pyrimidine biosynthesis in Bacillus subtilis
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:41:16Z Item is restricted indefinitely.
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High-resolution mapping of abasic sites and pyrimidine modifications in DNA
The maintenance of genomic stability is critical for the growth and survival of cells. Cellular DNA is constantly subject to both endogenous and exogenous sources of damage, leading to the formation of damage products. Abasic sites occur when a nucleobase is lost from DNA by hydrolysis and can lead …
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Development and application of bioorthogonal palladium- labile derivatives of cytotoxic pyrimidine analogues
… device) capable of activating cytotoxic pyrimidine analogue prodrugs masked with Pd0-labile protecting groups. Both the Pd0 functionalized resins and the BOOM-activated prodrugs are independently non-cytotoxic. However, once in combination together, the Pd0 is capable of mediating the …
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Molecular Cloning and Expression of the Pyrimidine B Gene From Bacillus Subtilis
The aspartate transcarbamylase of Bacillus subtilis is an example of a "vegetative" gene product which ceases to be synthesized once the cells begin to sporulate. To study the regulation of expression of this enzyme, the gene which encodes it (pyrB) was cloned from B. subtilis. Chromosomal DNA from …
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Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
… and nucleotide sugars through two pathways: pyrimidine salvage or de novo synthesis using glutamine. However, T. brucei lacks several key pyrimidine transporters and enzymes found in mammals, creating an area of parasite vulnerability, especially in the ability to maintain balance between …
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The regulatory roles of PyrR and Crc in pyrimidine metabolism in Pseudomonas aeruginosa
The regulatory gene for pyrimidine biosynthesis has been identified and designated pyrR. The pyrR gene product was purified to homogeneity and found to have a monomeric molecular mass of 19 kDa. The pyrR gene is located directly upstream of the pyrBC' genes in the pyrRBC' operon. Insertional …
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