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Showing 1 to 20 of 85 for “"pyridines"”.
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Synthesis and reactions of some pyridines and thienopyridines
… the preparation of this and other 3-substituted pyridines were investigated and a novel workup procedure for oxidation with <i>m</i>-CPBA (<i>m</i>-chloroperbenzoic acid) is described. The preparation of ethyl 2-chloro-3-pyridylacetate and several polychlorinated pyridine derivatives are …
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Pyrrolo [2-3-b] Pyridines of Potential Chemotherapeutic Value
The methods available for the synthesis of pyrrolopyridines and the biological activity of the pyrrolo [2,3-b] pyridines are reviewed briefly. The reasons for the synthesis of pyrrolo [2. 3- b] pyridines from a pyrrole precursor are discussed and the possible routes from the available starting …
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Bicyclic Heterocyclic Systems Derived from 1, 3, 4-Trisubstituted Pyridines
The preparation of 1,3,4-trisubstituted pyridines and their conversion into bicyclic systems are reviewed. The work described in this thesis concerns the preparation of 1,3,4-trisubstituted pyridines, by both existing and novel routes, and the conversion of these precursors into bicyclic systems. …
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Synthesis of pyridines via [4 + 2] cycloadditions of vinylallenes with azadienophiles
Pyridines are an important class of heterocycle with widespread applications. However, the efficient preparation of substituted pyridines remains a challenge in organic synthesis. This thesis describes new annulation strategies for the synthesis of highly substituted pyridines that involve [4 + 2] …
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The preparation of coordination compounds of rhodium III and some substituted pyridines
… position of bonding. For one complex of the aminopyridines an N.M.R. spectrum will be examined.
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Studies in isothiazole chemistry: I. isothiazolo [5,4-b] pyridines. II. approaches to isothiazolynes
… synthesis and chemistry of isothiazolo[5,4-b] pyridines. The syntheses of a number of alkyl isothiazolo[5,4-b] pyridines from 5-amino-3-methylisothiazole under conditions of the Skraup reaction are described and their nuclear magnetic resonance spectra are discussed. The reactions of 3-methyl- …
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Stereoselective monoalkyl diazene synthesis for mild reductive transformations : direct synthesis of densely substituted pyridines and pyrimidines
I. N-Isopropylidene-N'-2-Nitrobenzenesulfonyl Hydrazine. A Reagent for Reduction of Alcohols via the Corresponding Monoalkyl Diazenes The development of a new reagent N-isopropylidene-N'-2-nitrobenzenesulfonyl hydrazine (IPNBSH) is described. IPNBSH is used in the reduction of alcohols via the loss …
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Synthesis of pyridines and azaindoles via Diels-Alder reactions of tosyl cyanide with vinyl- and heteroarylallenes
Pyridines are an important class of heterocycle with widespread applications in a variety of areas. The efficient synthesis of highly substituted pyridines is an ongoing goal of modem synthetic chemistry. Part I of this thesis describes a new synthetic strategy for the synthesis of highly …
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Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
In Breast Cancer(BCa), steroid receptors play a key role in the progression of the majority tumours. Oestrogen Receptor-α (ERα), for example,drives the growth of approximately 70% of tumours and is therefore a useful therapeutic target for this disease.Interestingly, the Androgen Receptor (AR) is …
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"Synthesis Of 1,10- And 3,8-alkyl Substituted Pyrido(1"",2"": 1',2')imidazo(4',5': 4,5)imidazo(1,2-(italic-a))pyridines"
… 1'',2'':1',2' imidazo 4',5':4,5 imidazo 1,2-a - pyridines have been synthesized and their properties compared with those of the parent compound.
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Structure-activity and structure-property relationships of antimalarial pyrimido[1,2-a]benzimidazoles, imidazo[1,2-a]pyridines, and imidazo[1,2-a]pyrimidines
Malaria is an infectious disease that continues to cause significant morbidity and mortality in countries with poor infrastructure, with the African region being the most heavily affected. An estimated 241 million malaria cases were recorded in 2020, with 627,000 deaths. Of these, 77% occurred in …
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Development of Pd Catalyzed Amidations & Applications to the Synthesis of Heterocycles
… 2</p> <p>A facile synthesis of imidazo[4,5-b]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine has been demonstrated, as …
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Studies Directed Toward the Synthesis of Streptonigrin
The synthesis of complex pyridines has been a consistent challenge in the field of organic chemistry. Although there are many methods to accomplish this task, few methods consistently allow the synthesis of highly substituted pyridines without substantial limitations on the resulting substitution …
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Diversification of 4-Alkylpyridines: Mining for Reactivity with Alkylidene Dihydropyridines
Pyridines are valued structures in pharmaceutical development. Using a soft enolization approach, we can diversify alkyl pyridines under mild conditions via alkylidene dihydropyridines (ADHPs). Recent work in our group has demonstrated the utility of ADHPs in palladium-catalyzed reactions. However, …
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