Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"pyridine derivatives"”.
-
Synthesis and application of pinene-pyridine derivatives in asymmetric catalysis
… herein focuses on the synthesis of chiral pinene-pyridine derivatives, and their application in asymmetric catalysis. Both transition metal catalysed and organocatalytic transformations were investigated. Chiral pyridine-phosphines based on α-pinene were synthesised and applied as efficient …
-
Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
… and chemotherapy drugs. Among these, pyridines have arisen as an important focus for programmed axon death. Pyridines are versatile molecules that are frequently incorporated in drugs and pesticides. Our previous research has demonstrated that the pyridine derivative vacor, a disused …
-
Novel chemical entities against tropical diseases: Peptidomimetic lipopeptides as new anti-orthoflavivirals and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives as new antimalarials
Contains fulltext : 310090.pdf (Publisher’s version ) (Open Access)
-
Synthesis of new chiral pyrylium salts, the corresponding phosphinine and pyridine derivatives and the kinetic studies of the epimerization of pyrylium salts.
… salts and their conversion to the corresponding pyridines and phosphinines. This work almost triples the number of reported chiral pyrylium salts, and also represents the first racemizable/epimerizable pyrylium salts. The derived phosphinines and pyridines represent rare alpha-chiral ligands for …
-
Direct synthesis of pyridine and pyrimidine derivatives
I. Synthesis of Substituted Pyridine Derivatives via the Ruthenium-Catalyzed Cycloisomerization of 3-Azadienynes. The two-step conversion of various N-vinyl and N-aryl amides to the corresponding substituted pyridines and quinolines, respectively, is described. The process involves the direct …
-
ΣΥΝΘΕΣΗ ΚΑΙ ΜΕΛΕΤΗ 0-ΚΙΝΟΝΙΜΙΝΟ-, 0-ΚΙΝΟΝΟ-ΜΕΘΙΔΟ- ΚΑΙ Ο-ΚΙΝΟΝΙΜΙΝΟ- ΜΕΘΙΔΟ- ΠΑΡΑΓΩΓΩΝ ΤΗΣ 9, 10-ΦΑΙΝΑΝΘΡΕΝΟΚΙΝΟΝΗΣ ΚΑΙ ΤΗΣ 1, 2-ΑΚΕΝΑΦΘΕΝΟΚΙΝΟΝΗΣ
… TO GIVE DIELS-ALDER PRODUCTS AND ALSO CONDENSED PYRIDINE DERIVATIVES . REACTIONS OF 10-METHOXY-IMINE-9-PHENANTHRENONE WITH METHYL- SUBSTITUTED AROMATIC COMPOUNDS LEAD TO THE FORMATION OF OXAZOLE- DERIVATIVES. 1,2-ACENAPHTHENEQUINONE-MONOXIME ALSO REACTS WITH STABLE AND SEMI-STABLE YLIDES AND THE …
-
Construction and Application of Reference Scales for the Characterization of Cationic Electrophiles and Neutral Nucleophiles
… like enamines, phosphanes and phosphites, and pyridines as well as by adding new electrophiles. Kinetic data for electrophile-nucleophile combinations were used for discussing structure-reactivity relationships, as well as for the analysis of mechanistic aspects. Reversible additions of …
-
Electron Spin Echo and Millimeter Wave Epr Studies of Disordered Solids
… weak nitrogen hyperfine coupling in a series of pyridine derivatives loosely bound to bis(benzoylacetonato)copper (Cu(benzac)$\sb2$) in solution. The ESE technique has also been employed to study weak, long range, unresolved, (matrix) hyperfine interactions in coal. Experimentally, electron …
-
Applications of planar-chiral heterocycles in asymmetric catalysis
… In view of the utility of planar-chiral pyridine derivatives such as 1, it occurred to us that pyridine N-oxides 3 might also prove to be effective asymmetric catalysts. We synthesized complexes 3a-c and were gratified to discover that 3a efficiently catalyzes the ring opening of …
-
Synthesis, characterization and reactivity of organometallic Zr(IV) carboxylate and titanium aminotroponiminate complexes
… complex. [Zr(CH2Ph)2(XDK)] reacts with various pyridine derivatives to yield the 7-coordinate pyridine adduct. An aryl isocyanide (2 equiv) reacts with [Zr(CH2Ph)2(XDK)] to afford the iminoacyl complex [Zr{11 2 -2,6- Me2PhNCCH2Ph}2(XDK)]. [Zr(CH2Ph)2(XDK)] is unreactive, however, towards weak …
-
An exploration of the solid-state architectures formed by 1,8-naphthyridine-2,7-dicarbonyl derivatives
… of tape formation by dicarbonyl substituted pyridine derivatives in the solid state, it was proposed that expansion of the hydrogen bonding array from three donor-acceptor pairs to four should increase the strength of the hydrogen-bonded array. Accordingly an investigation into the …
-
Stereoselective monoalkyl diazene synthesis for mild reductive transformations : direct synthesis of densely substituted pyridines and pyrimidines
… selective manner. III. Direct Synthesis of Pyridine Derivatives A single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyridine and quinoline derivatives, respectively, is described. The process involves amide activation with trifluoromethanesulfonic anhydride in …
-
Design and synthesis of cyclometalated transition metal complexes as functional phosphorescent materials
… this thesis, a series of 2-(1,2,3-triazol-4-yl)-pyridine derivatives, referred to as the "click" ligands, are used to build phosphorescent Ir(III) and Pt(II) compounds. The robust and tolerant nature of the copper mediated 1,3-dipolar cycloaddition reactions offers great flexibility in the …
-
An exploration of supramolecular tape-like assemblies formed by pyridine dicarboxylates
… previous survey of the solid-state behaviour of pyridinedicarboxylate diesters, an overview of which is presented in Chapter 1. These compounds have been shown to form tape-like assemblies, mediated by a novel triple hydrogen bond motif.<br/>Chapter 2 examines the behaviour of a small subset of …
-
Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
… resistant stage of the disease. Thieno[2,3-b]pyridine derivatives have been previously demonstrated to be effective inhibitors in BCa. Here we expanded the research by investigating the efficacy of these compounds upon PCa. Using growth assays, flow-cytometry analysis, florescent imaging and …
-
Pyrrolo [2-3-b] Pyridines of Potential Chemotherapeutic Value
The methods available for the synthesis of pyrrolopyridines and the biological activity of the pyrrolo [2,3-b] pyridines are reviewed briefly. The reasons for the synthesis of pyrrolo [2. 3- b] pyridines from a pyrrole precursor are discussed and the possible routes from the available starting …
-
Synthesis and reactions of some pyridines and thienopyridines
… of 3-ethyloxycarbonyl-2-methylthiothieno[2,3-b]jpyridine. The multistep synthesis of this compound is reviewed and improvements described. The first step is the N-oxidation of ethyl 3- pyridylacetate, so reagents for the preparation of this and other 3-substituted pyridines were investigated and …
-
Mg- and Zn-Mediated Synthesis of Heterocycles in Solution and on the Solid Phase
… In the first part, functionalized zinc derivatives were used due to their high functional group tolerance. Thus various thymine derivatives have been prepared both in solution and on the solid phase. Alternatively, a new route to functionalized heterocyclic Grignard reagents was …
-
The synthesis and reactions of thienopyridines
The synthesis of <i>ortho</i>-halogenated pyridine derivatives (A-D; R = CN, CO<sub>2</sub>Et; R<sub>1</sub> = CN, CO<sub>2</sub>Me, CO<sub>2</sub>Et) containing methylene groups activated by the nitrile or ester functionality is described. Derivatives (A-D) are reacted with carbon disulfide in the …
Page 1 of 2