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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"pyrazoles"”.
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… azole core to rapidly access highly substituted pyrazoles will be discussed. Part II of this thesis addresses two separate targets to modulate neuroplasticity. In Chapter 2, the TrkB receptor as a potential target for pharmacological modulation is examined. Its signaling, role in brain disease, …
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Development of Combinatorial Approaches Towards Selective Estrogen Receptor Modulators: Investigations of Acyclic Amides and Tetra-Substituted Pyrazoles
In addition, four basic side chain-containing pyrazoles that mimic potentially favorable orientations in the ER binding pocket were synthesized. Among the four sites for basic side chain incorporation, the C (5) piperidinylethoxy-substituted pyrazole was found to have the highest affinity and to be …
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ΜΕΛΕΤΗ ΑΝΤΙΔΡΑΣΕΩΝ ΠΡΟΣΘΗΚΗΣ ΠΥΡΑΖΟΛΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΜΕ 1, 3-ΔΙΠΟΛΑ ΚΑΙ ΚΕΤΕΝΕΣ
STUDY OF THE REACTIONS OF PYRAZOLES DERIVATIVES WITH NITRILOXIDES, NITRILIMINESAND KETENES. NON AROMATIC METHYLENE- PYRAZOLES IN PRESENCE OF NITRILOXIDE AND NITRILIMINES UNDERGO STEREOSELECTIVELY 1,3-DIPOLAR CYCLOADDITION, IN PRESENCE OF DIPHENYLNETENE THE CORRESPONDING 1-DIPHENYL-ACETYL …
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Bioorthogonal Reagents: Design, Synthesis, and Reactivity
… This study ranges from the development of 4H-pyrazoles as bioorthogonal reagents to an exploration of the physical organic chemistry of 5-membered cyclic dienes that accelerate or impede their reactivity in Diels–Alder reactions. I show that 4H-pyrazoles can react rapidly as Diels–Alder dienes …
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Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.
… for the facile synthesis of various uracils, pyrazoles and pyrazolo [3,4-d] - pyrimidines with alkyl, aryl and glycosyl substituents such that the nature of the ring substituents is easily varied. To this end a number of ethoxymethylene reagents were prepared which, by reaction with primary …
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The synthesis and properties of selected transition metal-pyrazole complexes and their application towards homogeneous catalysis
… 5-dimethyl pyrazole complexes by reaction of the pyrazoles with NiCl 2 (PPh3) 2 and RuCl 2 (PPh3)3 respectively. The reactions of the same pyrazoles with RuBr 2 (PPh3)3 and [RuI 2 (PPh3) 2 ] n/ have also been investigated. The preparations have yielded new Ru(II) pyrazole complexes and although …
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Anion-Tuning of Supramolecular Gel Properties
… compounds, chiral bisureas and urea derivatised pyrazoles are studied. The synthesized chiral bisurea compounds act as gelators in a variety of solvents. Addition of anions in the form of tetrabutyl ammonium salts was found to afford break up of the gels. Studies reveal that the rheological …
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Estrogen Receptor Subtype Selective Ligands
… pyrazole compounds to produce basic side-chain pyrazoles (BSC-pyrazoles), which are high affinity, potent, selective antagonists on ERalpha. To understand the basis of ligand binding and potency selectivity for these ER subtype-selective ligands, we generated a series of ER chimeras using DNA …
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Palladium-catalyzed C-N cross-coupling and application to the synthesis of delayed singlet emitters for OLED development
… efficient access to N-arylated imidazoles and pyrazoles in moderate to excellent yields. In Chapter 3, a series of novel triptycene-based compounds were synthesized using a palladium-catalyzed C-N, C-C, C-N cross-coupling sequence. Experimental results suggest that this series of compounds …
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Exploration of Carbon-oxygen and Carbon-nitrogen Bond Formation Utilizing Trichloroacetimidates and Investigations of New Reactions Mediated By Oxoammonium Salts
… this reaction has been investigated. N-Alkylated pyrazoles and benzotriazoles are present in a number of natural products and pharmaceuticals. However, methods of synthesizing pyrazoles and benzotriazoles generally use hydrazine derivatives and limited regioselectivity. N-Alkylated pyrazole …
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Carbon−Hydrogen Bond Functionalization using Removable Monodentate Directing Groups
… Ozonolysis of ortho-arylated arylpyrazoles gave acylated biphenylamines that were further arylated to afford unsymmetrically substituted 2,6-diarylacetanilides. Chapter 2: N-Aminopyridinium ylides were used as mono-dentate directing groups for copper-promoted C−H/N−H coupling of …
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Synthesis And Characterization Of Group 5 Metal Complexes Containing Pyrazolate, Amidate, And Related Ligands As Potential Precursors For Thin Film Growth By Atomic Layer Deposition
… the aromaticity of those metallacycles against pyrazoles and pyrimidines, NICS calculations were performed. The metallacycles were found to be aromatic but only weakly aromatic than that of pyrimidines and pyrazoles. </p> <p> In order to synthesize metal complexes that are in the +4 oxidation …
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Trichloroacetimidates As Outstanding Electrophiles for the Carbon-nitrogen, Carbon-oxygen and Carbon-carbon Bonds Formation and Synthetic Studies of Protein Phosphatase-5 (pp5) Small Molecule Inhibitors
… the utility of the this developed protocol. Pyrazoles are a group of resourceful heterocyclic compounds with their presence seen in a variety of current medications, potential illness treatments, natural products, and pharmaceutical intermediates. However, N-alkylation of these systems can be …
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Molecular, Biochemical, and Toxicological Evaluation of Anticholinesterases for control of the Malaria Mosquito, Anopheles gambiae
… and the substrate, acetylcholine. Monovalent pyrazoles and acetophenone oxime carbamates were toxic to both susceptible and carbamate-resistant mosquitoes carrying a G119S mutation within the catalytic site. A bivalent phthalimide-pyrazole carbamate and sulfenylated phenyl N-methyl carbamates …
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Polar Tris(pyrazolyl)borates for the modeling of Zinc metalloenzymes in aqueous solution
… polar substituents on the 3-position of the pyrazoles were expected to contribute to this. These comprise the carboxyester substituted BpC(O)OR,Me (R = Me, Et), the pyridyl substituted Tp4'Py,Me and Tp4'(6'Me)Py,Me, and the carboxyamide substituted TpC(O)NHPh,Me ligands. <br>The water soluble …
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The synthesis and structural characterisation of novel 4- and 5- membered nitrogen heterocycles derived from azoacetates
… incorporated into the cyclic system to produce pyrazoles, or as an exocyclic pendant group attached to a 2- iminopyrrolidin-5-one; X-ray crystal structures of these compounds are reported. The 2- iminopyrrolidin-5-one was easily modified to produce the corresponding pyrrolidine-2,5-dione …
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Reactions and rearrangements of chroman-4-ones and related compounds
… to prepare a range of benzopyrano isoxazoles, pyrazoles. pyrroles and pyrimidines. 3-Hydroxymethylenespiro[chroman-2. 1 '-cyclopentan]-4-one is particularly unstable to acid-base conditions. Attempts to prepare this compound resulted only in the formation of 3-(1 cyclopentenyl)chromone, arising …
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The gas chromatographic separation properties of azulene and the synthesis and characterization of bulky bis-pyrazolylpyridine metal-ligand complexes.
… is significantly distorted from the plane of the pyrazoles and metal. The Ru, Cu, and Fe complexes show quasi-reversible redox couples.
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Synthesis of Novel CYP1 Activated Heterocyclic Anticancer Prodrugs
… as the control. A library of eighteen 3,5-diarylpyrazoles were synthesised. The lead pyrazole DMU 10107 (3-(2,3,4-trimethoxyphenyl)-5-(3,4-methylenedioxyphenyl)pyrazole) gave an IC50 value of 8μM towards the MDA 468 cell line. The MCF7 cells, TCDD induced and non-induced gave IC50 values of 10μM …
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Utilisation des diazirines comme source d'azote électrophile pour la synthèse d'hydrazines et d'hétérocycles
… d’hydrazines pour permettre la synthèse de pyrazoles et d’indoles. Aussi, l’utilisation de l’adamantanone comme support de diazirine permet le recyclage de cette molécule, pouvant être réutilisée pour la synthèse de la diazirine de départ. Le deuxième chapitre traite de la synthèse …
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