Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 85 for “"pyramidal neurons"”.
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Molecular Dissection of IA Channels in Cortical Pyramidal Neurons
… current, I <SUB>A</SUB>, is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, back propagation: into dendrites) of action potentials, and responses to synaptic inputs. Interestingly, results from previous studies on a number of neuronal cell …
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Modelling the somatic electrical response of hippocampal pyramidal neurons
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1987.
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Distinct Populations of Layer 5B Pyramidal Neurons in the Primary Motor Cortex
… depends on the coordinated activity of many neurons found across its laminar structure. Layer 5b (L5b), a deep cortical layer that drives output signals from the cortex, contains excitatory pyramidal neurons that innervate many subcortical areas of the brain. In the motor cortex, L5b is …
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Optical imaging of dendritic spikes in apical oblique dendrites of layer 5 pyramidal neurons
… role of apical oblique dendrites of layer 5 pyramidal neurons (L5PNs) are less understood. In this thesis, I aim to understand to functional role of thin apical oblique dendrites of L5PNs in the cortex. Using a previously published multi-compartment model of a L5PN, I first investigated the …
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Optical imaging of dendritic spikes in apical oblique dendrites of layer 5 pyramidal neurons
… role of apical oblique dendrites of layer 5 pyramidal neurons (L5PNs) are less understood. In this thesis, I aim to understand to functional role of thin apical oblique dendrites of L5PNs in the cortex. Using a previously published multi-compartment model of a L5PN, I first investigated the …
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Cellular and Synaptic Morphology of Golgi -Impregnated Cortical Neurons in Patients With Schizophrenia
… reveal that despite normal numbers of cortical neurons, patients exhibit anatomical reductions in synaptic connectivity. Prefrontal regions have been implicated as a site of vulnerability to pathophysiological alterations, while evidence of anatomical disturbances in other cortical regions …
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Cell-type specific cholinergic modulation of the cortex
… Chapter 2 identifies somatostatin-expressing neurons as a dominant player in driving decorrelation and information processing through its intimate interactions with parvalbumin-expressing and pyramidal neurons. Chapter 3 highlights astrocytes and their interactions with pyramidal neurons as …
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EFFECTS OF ENHANCING ANANDAMIDE LEVELS ON HIPPOCAMPAL NEUROPHYSIOLOGY AND SHORT-TERM MEMORY PROCESSING IN RATS
… memory by altering neuronal activity of pyramidal neurons present in the hippocampus. In this study extracellular action potentials were recorded using multi-neuron electrodes implanted in the CA1 and CA3 subfields of the hippocampus. The acute effects of R-Methanandamide; VMD11 and …
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Electrophysiological characterization of a mouse deficient for oligophrenin1: a mouse model of X-linked mental retardation
… Investigation of the synaptic properties of CA3 pyramidal neurons using the patch-clamp technique has been undertaken. I have shown reduced inputs of excitatory and inhibitory neurotransmission to CA3 pyramidal neurons accompanied with reduced frequency dependent facilitation of the inhibitory …
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Cortical Pyramidal Neuron Subtype Classification and Visual Response Diversity
… and computation. The classification of pyramidal neurons into functional subtypes remains a crucial part of this survey since the subtype-specific division of labor creates a rich substrate for computation. However, the extreme integration of individual neurons into the collective cortex …
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Spontaneous activity in the mouse visual cortical slice: biophysical characterization and pathophysiology
… cations render extratelencephalic layer 5 pyramidal neurons intrinsically active by altering the activity of the persistent sodium current. In Chapter 3, I detail my journey investigating the pathophysiology underlying the hyperactivity phenotype in Fmr1-KO mice. While my early …
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Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions
… Indeed, many studies of spine density of pyramidal neurons in sensory cortex indicate that an average of ~1.4 spines/micron occurs is present (Briner et al., 2010). Most such studies examined dendritic spines from primary sensory areas which are dominated by inputs from a single sensory …
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The role of fast-spiking interneurons in cortical map plasticity
… this thesis. I focused on fast-spiking (FS) interneurons, which are thought to play an important role in<br/>adult cortical plasticity. I made electrophysiological recordings in layer 2/3 to determine how inhibitory circuitry in deprived cortex is affected by whisker deprivation. The amplitude of …
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Top-down and bottom-up interactions for cortical bursting
… a powerful subcellular substrate by which single pyramidal neurons could multiplex bottom-up and top-down information via L1-independent tonic spikes and L1-dependent bursts, respectively, and have provided a basis for emerging theoretical models of cortical computation and learning. However, our …
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Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation
<p>One of the most characteristic features of pyramidal cells in the prefrontal cortex (PFC) is that they present a slow afterhyperpolarizing current (I<sub>sAHP</sub>) that plays a critical role in the regulation of neuronal excitability. This current is modulated by receptors acting via …
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Structural and functional heterogeneity of cells in the rat hippocampus
… to the CA3 and subsequently the CA1 layer. CA1 pyramidal neurons are the primary hippocampal projection neurons that provide a significant output pathway from the hippocampus. DG granule neurons are the primary signal receivers from the major input pathway through the Perforant Path (PP) from …
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Exploring the effects of classical immune activation on circuit excitability and cell viability in the mouse brain
… as well as the synaptic strength between pyramidal neurons after immune activation. I found no changes in the basic membrane properties of pyramidal neurons after short term neuroinflammation, but I did observe changes to the function of hippocampal networks at intermediate (24 hours) and …
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Impact of Noise and Spike Initiation Properties on the Encoding and Transmission of Neural Information
Neurons use action potentials, or spikes, to process information. Different aspects of spiking, such as its rate or timing, are used to encode information about different features of an input. But noise can influence how robustly information is represented in each coding scheme. Additionally, …
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