Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"pyramidal cell"”.
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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… discrimination and memory consolidation. The cellular heterogeneity of the neocortex makes it difficult to understand the molecular and cellular substrate of cognition during normal brain function and disease related dysfunction. A deep understanding of the contribution of the neocortex to …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… area CA1, interactions between excitatory pyramidal cells and inhibitory interneurons shape ensemble activity which encodes sequential experience. An extremely diverse set of inhibitory interneurons, with variation in gene expression, synaptic targeting, state-dependent activity, and …
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ADENOSINE SYSTEM DYNAMICS AND SK CHANNELS MODULATE BASOLATERAL AMYGDALA PYRAMIDAL CELL EXCITABILITY: IMPLICATIONS FOR ANXIETY DISORDERS AND COMORBID ETHANOL ABUSE
Alcohol use disorders (AUDs) impart serious social and economic costs on society. For example, nearly 1 in 18 Americans abuses or is addicted to alcohol, contributing nearly $234 billion per year in socioeconomic costs. Despite this, effective pharmacological treatments remain elusive. To aid in …
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The effect of Alzheimer's disease on cortical microcircuits
… models can support inferences around laminar and cell-specific disease effects from human non-invasive imaging. This thesis aims to use dynamic causal models to elucidate cellular-level effects of Alzheimer’s disease on cognition to (i) improve our understanding of disease mechanisms and (ii) …
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Impact of Corticosterone and Zinc Deprivation on Memory and Hippocampal Functioning
… and subsequent chronic CC release, damage to the cell bodies and neurons of the hippocampus have been found. This is problematic because the hippocampus plays a role in memory and learning mechanisms. Memory problems are also present in stress-related disorders such as post-traumatic stress …
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Two-Dimensional Electrode Array Studies of Propagating Epileptiform Neural Activity in the Rat Hippocampal Slice
… underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of …
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Temporal synchronization of CA1 pyramidal cells by high-frequency, depressing inhibition, in the presence of intracellular noise
… Wave-associated Ripple is a high-frequency, extracellular recording observed in the rat hippocampus during periods of immobility. During the ripple, pyramidal cells synchronize over a short period of time despite the fact that these cells have sparse recurrent connections. Additionally, the timing …
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Adenosinergic modulation of hippocampal gamma oscillations: from single cell to whole animal
… vitro. Sharp electrode current clamp and whole-cell voltage clamp experiments showed that \(A_1\)-receptor activation hyperpolarised resting membrane potential, reduced firing rate and EPSP amplitude and shifted the IPSC reversal potential to more negative potentials. Blocking \(A_1\)-receptors …
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Impaired and enhanced spatial representation of the PSD-95 knockout mouse
… absent in the mutants. This study explores CA1 pyramidal cell spatial representations in the PSD-95 mutant mice. Mutants are not significantly different than controls in running velocity. Nor are its pyramidal cells or interneurons different than controls in: place cell firing rates, sparsity of …
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Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
… such as primary dendrite length and cell soma size of pyramidal neurons in the hippocampus. I found that PGE2 exposure decreased LTP in males and I/O responses in females at higher stimulation intensities with no effect on PPF. PGE2 also increased the expression of NMDAR2A in males …
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Role of the Transient Receptor Potential Channels in Modulating Prefrontal Cortical Excitability and the Behavioral Responses to Cocaine
… with drug addiction. We show that layer 5 pyramidal neurons in the PFC exhibit a prolonged depolarizing response to Gq-coupled receptor activation, which produces a period of heightened excitability of the cell following brief bursts of action potential activity. This burst triggered …
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The Manipulation Of Apical Dendritic Plasticity And The Consequences For The Effects of Chronic Stress
<p>Pyramidal cell apical dendrites in region CA3 of the hippocampus of male rats collapse in size and complexity following chronic stress. These dendrites return to control sizes with a recovery period. This suggests that dendritic remodeling can function as a protective response mechanism, …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… in regional hippocampal anatomy and subicular pyramidal cell morphology with homology to abnormalities reported in schizophrenia. Specifically, we found a decrease in dendritic spine density in specific regions of the dendrite of ventral subicular neurons. At the neurophysiological level, we …
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Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… redistributed to non-synaptic sites, whereas on pyramidal neurons the clusters appeared to disperse. Furthermore, in control neurons AMPA receptors were extractable from pyramidal cell spines, whereas AMPA receptors on GABAergic neurons were unextractable. The synaptic clustering of PSD-95, a …
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An Electrophysiological Analysis of the Primary Input to the Cat Prepyriform Cortex
… been reported. We found that a given cortical cell could be activated equally well from sites anterior or posterior to the recording electrode. This supports the anatomical work of others showing collaterals leaving the tract to synapse with cortical cells, with the main axon sending …
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Biologically plausible energy-efficient context-sensitive neural networks
The rapid advancements in artificial intelligence (AI), particularly in deep neural networks (DNNs), have significantly driven the demand for specialised hardware, such as GPUs and TPUs, to meet the growing computational requirements. However, this surge in computational power has led to …
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The mechanisms of reliable coding in mouse visual cortex
… to provide distinct forms of inhibition onto pyramidal neurons. Using a novel combination of dual-color calcium imaging and optogenetic manipulation, I have discovered that the SST->PV inhibitory circuit plays a crucial role in modulating pyramidal cell reliability. In particular, by …
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Effect of Background Synaptic Activity on Excitatory-Postsynaptic Potential-Spike Coupling
… the<em> in vivo</em> synaptic activity of the cell with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices<em> in vitro</em> to investigate how timing and probability of spike generation in response to an EPSP is affected by background synaptic conductance under …