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Showing 1 to 20 of 201 for “"purine"”.
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Purine transport in plasmodium falciparum
Purine transport in malaria parasites has become an important potential drug target because the malaria parasite is unable to synthesis purine de novo and has to salvage it from the host milieu through transporter(s). Knowledge of the number, selectivity and kinetic parameters of the transporters …
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Factors Influencing Muscle Purine Nucleotide Metabolism.
… the factors influencing the metabolism of purine nucleotides in human skeletal muscle, plasma and urine. Study one investigated the influence of the number of intermittent sprint bouts and the subsequent accumulation of plasma purines and urinary purine excretion. Study two investigated the …
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Defined Dimensional Changes in Purine Analogues
Pyrazolo{4,3-g}quinazolin-5-one (lin-benzoallopurinol), an extended analogue of 4-hydroxypyrazolo{3,4-d}pyrimidine (allopurinol), and pyrazolo{3,4-f}quinazolin-9-one (proxbenzoisoallopurinol), an extended analogue of 7-hydroxypyrazolo{4,3-d}pyrimidine (isoallopurinol), have been synthesized. The …
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Aspects of purine and pyrimidine metabolism
… membrane transport and metabolism, and purine and pyrimidine metabolism is presented. The effects of pH, pO₂ and inorganic phosphate (Pi) on the uptake and metabolism of hypoxanthine by erythrocytes has been studied in Chapter 2. Uptake of hypoxanthine and accumulation of inosine …
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Screening for purine transporters in S. aureus
… pathogenesis depends on its ability to acquire purines to cause disease. In this study, I screened a library of individual mutants under purine import-dependent conditions by inhibiting the purine biosynthesis using the pharmacological agents methotrexate and 6-mercaptopurine and supplementing …
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Analysis of dirhenium carboxylate : purine dinucleotide adducts
… of cancel cells by coordinating to the purine nucleobases in DNA. To investigate the interaction between dimetal compounds and DNA, dirhenium complexes coordinated to purine dinucleotides were isolated and analyzed. LC/MS, HPLC, <sup>1</sup>H NMR, and UV-Visible spectroscopy were used to …
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Modified Purines. Rearrangement Through 5-Substituted Purine Intermediates
A novel rearrangement has been utilized for the synthesis of imidazo{1,5-a}-1,3,5-triazinones (1) which are analogues of N(9)-substituted guanines, hypoxanthines, and xanthines. Structures were established in this series (1) on the basis of precursors and routes of synthesis, infrared spectra, mass …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
… Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA), an inhibitor of de novo purine synthesis, attenuates stemness of MTAP-deficient GBM cells. This ALA-induced reduction in stemness is mediated in part by …
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Geometrical Analogues of Purine Substrates (5-Methyladenine, Pyrolysis, Diazabiphenylene)
… approaches are developed to cyclobutadienopurines and lin-benzocyclobutadienopurines, new extended purine analogues, by means of flash vacuum pyrolysis of suitable condensed pyridazine precursors. As a model for the cyclobutadienopurine ring system, benzo{3,4}cyclobutadieno{1,2-d}imidazole …
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Synthesis of Purine Derivatives as Probes of Hormone Receptors
Made available in DSpace on 2014-12-13T20:10:20Z (GMT). No. of bitstreams: 1 7804173.pdf: 4957165 bytes, checksum: 32cfa701808e660b6b3f7170b110349f (MD5) Previous issue date: 1977
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An Organic Chemical and Biological Investigation of Purine Derivatives
Made available in DSpace on 2014-12-10T23:01:42Z (GMT). No. of bitstreams: 1 7412018.pdf: 4234960 bytes, checksum: a97e7cb61aee0c62a9bb0c75c8f35e2d (MD5) Previous issue date: 1973
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Cellular and Organismal Ramifications of de novo Purine Synthesis Dysregulation
<p>Purines are a class of nitrogenous bases and are essential small molecules to life. Purines are used within the cell as genetic information carriers, energy currency, signaling molecules, and cofactors for multiple processes. They are formed through <em>de novo</em> and salvage pathways found in …
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Studies of the purine biosynthetic pathways in the gastrointestinal tract.
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Nutrition and Food Science, 1979.
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Some in vivo effects of triiodothyronine on purine nucleotide synthesis
… of triiodothyronine on the synthesis of hepatic purine nucleotides was investigated in sulfaguanidine-fed hypothyroid rats. To prevent the rapid destruction of nucleotides caused by anoxia and ischemia an apparatus was designed to maintain ether anesthesia while providing normal levels of oxygen. …
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Biochemical Studies of the Purine Analogues, 2-Aminopurine and 2,6 Diaminopurine
<p>An alternating copolymer of deoxy 2,6 diamino purine and thymine (dDAP-T) has been synthesized by substituting 2,6 diamino purine deoxyriboside triphosphate for dATP in a dAT primed synthesis with DNA polymerase. This polymer differs from dAT in having an amino group in the minor groove, and in …
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Nitrogen-14 Nuclear Quadrupole Resonance Studies of Pyrimidine and Purine Derivatives
The classical and quantum mechanical descriptions of nuclear quadrupole resonance (nqr) are reviewed. Fundamental principles of nuclear spin thermodynamics are introduced to explain double resonance via level crossing (drlc), the experimental technique employed to detect ('14)N nqr resonances.
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Equilibrium Dialysis Studies of Purine and Pyrimidine Binding to Rabbit Myofibrils
Made available in DSpace on 2014-12-05T20:55:38Z (GMT). No. of bitstreams: 1 5805447.pdf: 2201465 bytes, checksum: af98da1dc92c66e90077493b47db502e (MD5) Previous issue date: 1958
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Two new activities and a new intermediate in the purine pathway
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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