Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"pulmonary metastasis"”.
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The Role Of Pkc Epsilon In Breast Cancer Cell Surface Polyfibronectin Assembly And Pulmonary Metastasis
… of breast cancer cells has been shown to mediate metastasis to the lungs. Disruption of the binding between these tumor-cell surface-associated fibronectin, or polymeric fibronectin (polyFn), and dipeptidyl peptidase (DPPIV) negatively impacts breast cancer lung colonization. This dissertation was …
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Micro-CT/PET Assessment of Lung Metastasis in a Mouse Model of Osteosarcoma
… 8th most common childhood cancer. Detection of pulmonary metastasis as early as possible is vital, since the presence of and progression or regression of pulmonary metastasis critically impacts prognosis and treatment. Thus pulmonary metastatic load is a method of determining treatment response …
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Targeting Pd-1/Pdl-1 Signaling In The Treatment of Osteosarcoma Lung Metastasis
<p>Osteosarcoma (OS) manifests itself as pulmonary metastasis, which is a major cause of death in OS patients. Novel treatments like immunotherapy hold promise for the treatment of OS pulmonary metastasis. However, immunosuppressive mechanisms such as binding of immune inhibitory receptor, PD-1 …
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Metadherin Functions As A Laminin Receptor That Is Essential For Metastasis and Is Associated With Poor Survival In Osteosarcoma
… is a highly invasive bone malignancy in which metastasis accounts for the vast majority of death and morbidity in patients. Understanding the mechanisms controlling metastasis is essential for improving patient survival in this disease. In order to improve the clinical outcomes for patients …
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Adhesion-GPCRs in cancer progression and metastasis
… possible roles in breast cancer progression and metastasis. Based on these analyses and cross-referencing with the published gene expression data on human breast cancer cell lines and patient samples, I chose two candidate genes, CELSR2 and GPR126, for more detailed investigation. To elucidate …
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Delineating the metastatic process in osteosarcoma; the role of bone cells, the cell environment and autophagy
… metastatic lesions. This links OC function to OS metastasis. Through an in vitro model of OS metastasis, we have found that the highly metastatic OS cell line HOS-143B contains a subset of highly migratory spheroids with enhanced expression of stemness and metastasis-associated genes OCT3/4 …
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Effect of Entinostat On Nk Cell-Mediated Cytotoxicity Against Os Cells and Os Lung Metastsis
… on the efficacy of NK cell therapy for OS lung metastasis. The Lung is the most common site of OS metastatic spread in OS and pulmonary metastasis is the main cause of mortality. We have previously demonstrated that NK cell therapy has minimal efficacy against OS metastasis. We wished to …
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Organ Specific Vascular Response to Fibrosis Affects Breast Cancer Metastatic Organotropism
… or bleomycin induced lung fibrosis enhancing pulmonary metastasis in mouse models of breast cancer. In addition to the evidence indicating that fibrosis enhances primary tumor growth and metastasis it is also well characterized that primary tumor metastasis has specific organotropism, for …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes for future patients. Unraveling the complexity of metastasis …
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The Role of Autophagy In The Sensitivity of Osteosarcoma Cells to Gemcitabine Treatment
… has remained unchanged in the last 20 years. Pulmonary metastasis continues to be the main cause of death; novel therapeutic strategies are urgently needed to improve the survival rate of these patients. Previous data in our laboratory has demonstrated that aerosol gemcitabine (GCB) treatment …
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
… COX-2 inhibitor to inhibit tumor growth and pulmonary metastasis in animal model. The right thighs of male, 6 week old C57/BL mice were injected subcutaneous with 1 x 106 Lewis Lung Carcinoma(LLC) cells. Animals were randomized to one of six groups: no treatment(group 1), celecoxib 25mg/kg …
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Platelet surface receptors and melanoma metastasis
Ziel dieser Arbeit war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. …