Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"pulmonary injury"”.
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Development of Immune Modulators Targeting Autoimmune Disorders and Pulmonary Injury: Design, Synthesis, and Biological Evaluation of Sphingolipid-Derived Sphingosine-1 Phosphate Receptor 1 Agonists
… can be of interest for treatment of acute lung injury and pulmonary endothelial cellular leakage.
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RAC1-Mediated Actin Cytoskeleton Remodeling and Monolayer Barrier Properties of Stretched Alveolar Epithelial Cells
… is vital for supporting patients with pulmonary insufficiency. However, experimental data suggests that pulmonary injury can occur during mechanical ventilation as a result of elevated regional lung volumes resulting in excessive alveolar epithelial cell (AEC) stretch due to basement …
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Effects of taurine and hypotaurine on oxidative lung injury
The present studies are based on the premise that pulmonary injury, during periods of hypoxia, ischemia, and reperfusion, may be due to increased production of reactive oxygen species, including the superoxide anion (O₂-), hydroxyl radical (-OH), and hydrogen peroxide (H₂O₂), and on the premise …
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Point-of-Care Ultrasound for Pulmonary Concerns in Remote Spaceflight Triage Environments
… modality for diagnosis and treatment of the pulmonary system, as air-interfaces disrupt ultrasound views. Researchers have recently identified various lung signs and patterns indicative of lung injuries and illness improving the utility of pulmonary ultrasound. The compact size and ease of …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… and acute lung injuries are two distinctive pulmonary disorders that result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through interaction with four …
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
… decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates cardiovascular disease including myocardial infarction. The impact of particulate matter on cardiovascular health has served as a backdrop concern raising questions …
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Acute pancreatitis - severity classification, complications and outcome
… disease. The dominating aetiology was alcohol. Pulmonary injury was the most common organ manifestation outside the pancreas. To reduce mortality due to acute pancreatitis it is important to target also the patients that never reach hospital.
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Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis
… Rac1 may be useful approach to protect against pulmonary injury in abdominal sepsis. Paper (II), in this study we showed that inhibition of Rac1 signaling protect sepsis-induced lung injury through two different mechanisms. First, Rac1 controls surface mobilization of CD40L on activated …
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Mechanisms of neutrophil recruitment in septic lung injury
… that CD44 may have a role in mediating pulmonary recruitment of neutrophils along with Rho GTPase subfamily in more than one way for enhancing neutrophil stiffness and migration. Peptides are new evolutionary compound with multifunctional effects, especially during infection and sepsis …
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Lung Progenitor Cell Transplantation for Pulmonary Fibrosis and Ex Vivo Expansion of Patch-Forming EpCAM⁺CD31⁺ Cells
<p>Idiopathic pulmonary fibrosis (IPF) and other chronic interstitial lung diseases are characterized by progressive destruction of the alveolar architecture, leading to irreversible respiratory failure. Although recent pharmacologic interventions can slow disease progression, lung transplantation …
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Investigating the cerebral/pulmonary axis following traumatic brain injury in a preclinical model
Traumatic Brain Injury (TBI) accounts for 1,000,000 hospital admissions in the European Union every year and is the leading cause of death in individuals under 45 years of age in both Europe and the United States. This thesis examines the consequences to both the brain and lung following TBI using …
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Feasibility Study of Low Dose Chest CT for Initial Evaluation of Blunt Chest Trauma Patient
… of the polytrauma patients including thoracic injury. However, the routine use of CT results in rapid increase of the CT radiation dose in blunt chest trauma evaluation. Therefore, according to the ALARA (as low as reasonable achievable) principle, radiation dose adjustment in the patients with …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… mice leads to the development of pulmonary inflammation, alveolar destruction, and fibrosis, in conjunction with IL-6 elevation. Thus, it was hypothesized that IL-6 contributes to pulmonary inflammation and fibrosis in this model. To test this hypothesis, <em>Ada/IL-6</em> double …
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Respiratory complications of organophosphorus pesticide poisoning
… agricultural formulation) causing a toxic lung injury which contributes to the observed high mortality. In this PhD, I aimed to characterise the lung injury caused by OP pesticide self-poisoning through both indirect (ingestion) and direct (aspiration) means. To achieve this, I analysed data …