Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"pulmonary infection"”.
-
Formulation and efficacy of liposome-encapsulated azithromycin for pulmonary infection due to Pseudomonias Aeruginosa
… recessive disorder in Caucasians. Recurrent pulmonary infection and inflammation are the major risk factors associated with cystic fibrosis. Microbial infection with highly resistant pathogens such as Burkholderia cenocepacia and Pseudomonas aeruginosa, is principally associated with cystic …
-
Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
… and incidence of Mycobacterium abscessus (Mab) pulmonary infections have increased and been recognized as a major cause of mortality, particularly in certain patient populations, such as cystic fibrosis (CF) patients. Due to the intrinsic multidrug resistance mechanisms and biofilm (BF) …
-
Dominant Suppression of Early Innate Immune Mechanisms by Yersinia pestis
… inflammatory response within a few hours of infection, but <italic>Yersinia pestis</italic> is strikingly different: the first 36 hours of infection are characterized by rapid bacterial replication in the lung without generating appreciable levels of proinflammatory cytokines/chemokines, …
-
Liposomal clarithromycin delivery for the treatment of pseudomonal lung infection in cystic fibrosis.
The pulmonary infection with Pseudomonas aeruginosa is considered as one of the main causes of health deterioration in cystic fibrosis patients (CF). Efficient management of P. aeruginosa in CF remains difficult mainly with the emergence of multidrug-resistant strains leading ultimately to death. …
-
Acquired infections in paediatric patients after cardiac surgery
Introduction: Hospital acquired infections (HAIs) are an important cause of morbidity and mortality following paediatric cardiac surgery. Aim: To determine the incidence, risk factors for and outcome of postoperative HAIs in the Paediatric Intensive Care Unit (PICU) of the Red Cross War Memorial …
-
In Vivo Gene Expression Profiling of the Plague Bacillus, Yersinia Pestis
… bite or inhaled aerosol. Both routes of infection have a high mortality rate, and pneumonic infections of Yersinia pestis represent a significant fear as a tool of bioterrorism. Understanding the transcriptional program of this pathogen during pulmonary infection is valuable to better …
-
Hypoxia and the regulation of host responses to acute bacterial pulmonary infections
Introduction – Severe pulmonary bacterial infections are frequently complicated by systemic hypoxaemia and, in the context of acute respiratory distress syndrome (ARDS), inappropriately prolonged neutrophilic inflammation. This combination of acute hypoxaemia and persistent inflammatory response …
-
ROLE OF CRC IN THE REGULATION OF ALGINATE IN PSEUDOMONAS AERUGINOSA
… the Cystic Fibrosis (CF) and chronic obstructive pulmonary disease (COPD) lung environments, mucoid strains often appear as a result of alginate overproduction. Such mucoid conversion is associated with the establishment of a chronic pulmonary infection. Alginate confers resistance to phagocytosis …
-
Modelling neuroimmune interactions using organotypic slice cultures
… predominantly manifests in the form of a pulmonary infection, but may spread out into other parts of the body and is then referred to as extrapulmonary tuberculosis (EPTB). One form of EPTB is an infection of the central nervous system (brain & spinal cord), CNS-TB. Although CNS-TB is …
-
The P-Rex1 Regulator Norbin Suppressess Neutrophil-Dependent Antibacterial Immunity
… deficiency provided increased immunity against pulmonary infection with Streptococcus pneumoniae, even in immune-deficient Prex‒/‒ mice. Neutrophil depletion showed that Norbin deficiency renders neutrophils important for combatting this infection. Mostly, Norbin deficiency overrode the …
-
The effect of helical carbon nanotubes on macrophage function
Occupational and environmental pulmonary exposure to carbon nanotubes (CNT) is considered to be a health risk with a very low threshold of tolerance as determined by the Center for Disease Control. Cell lines exposed to CNTs show a diverse range of adverse effects including reduced viability, …
-
PI3Kδ in B cell Homeostasis and Transformation
… primary immunodeficiency with increased risk of pulmonary infection, autoimmunity, and B cell lymphoma development. This thesis explores the role of hyperactive PI3Kδ in B cell homeostasis, maintenance, and malignant transformation. The Okkenhaug lab has previously identified a novel mouse model …
-
Regulation of Adaptive Immunity in the Lung by the Alveolar Epithelial Type II Cell and Surfactant Protein a
… removal of the type II cells. Using a model of pulmonary infection with Mycoplasma pneumoniae, wildtype mice were found to have fewer mature dendritic cells in the mediastinal lymph nodes than SP-A null mice. The presence of SP-A in the wild-type mice had a suppressive effect on the M. …
-
Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… prerequisite for their accumulation at sites of pulmonary infection and inflammation. To begin to assess the pathobiological importance of alterations in monocyte adherence to extracellular matrix in inflammatory lung diseases, the adherence properties of monocytes from patients with an …
-
Hospital Infection Control Practice: Preventing, Identifying, and Measuring Healthcare-Associated Infections in an Ever-Changing Environment
<p>Healthcare-associated infections (HAIs) are a cause of significant morbidity and mortality in U.S. hospitals. HAI prevention is receiving increased attention on account of recent legislative mandates related to public reporting of hospital infection rates and limitations in hospital …
-
The clinical relevance of structural modifications in the cell envelope glycans of Mycobacterium abscessus
… abscessus is one of the leading causes of pulmonary disease caused by nontuberculous mycobacteria (NTMs) globally. As an opportunistic pathogen, individuals who have dysfunctional immunological and/or mechanical defenses are at the greatest risk of acquiring M. abscessus, but individuals …
-
Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
… dissemination to distant sites, to an isolated pulmonary infection. Treatment of melioidosis can be problematic because it is often difficult to diagnose and Bp is resistant to a diverse group of antibiotics. Even with treatment, the mortality rate of melioidosis is 20 to 50%.</p> <p>While this …
-
Analysing M. abscessus-macrophage interactions and investigating treatments for M. abscessus and S. aureus intracellular bacterial infections, using a continuously growing, primary cell model of lung alveolar macrophages
… pathogens capable of causing a range of infections in humans, and pulmonary infections are significant amongst them. During pulmonary infection, alveolar macrophages (AMs), as sentinel immune cells of the airways, are key cells for the recognition of these invaders, and they are central …
-
The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system
… is infected with latent TB. It is a single infection that causes most deaths and was the number one cause of death in South Africa in 2017. Bacille Calmette-Guerin (BCG) remains the only licensed vaccine for protection against TB. Although TB primarily occurs as a pulmonary infection after …
-
Microbial interactions with epithelial surfaces.
… may be also be involved in staphylococcal pulmonary infections. Recently, several community-associated strains of S. aureus have been linked with severe and often fatal pulmonary diseases. I have found that these strains produce superantigens such as toxic shock syndrome toxin-1 (TSST-1), …