Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"pulmonary hypoplasia"”.
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Investigating WNT signalling in the lung
… to respiratory distress resulting from lung hypoplasia. If this stage is survived, the chances of long-term survival have been noted to increase to 80%. The specific etiology of this hypoplasia has remained unknown; however, it has been linked to kidney enlargement and oligohydramnios. As a …
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Assessment of fetoscopic tracheal occlusion using ultrasound images in phantom study
… the heart and lungs. This crowding can lead to pulmonary hypoplasia. Newborns with underdeveloped lungs have severe respiratory insufficiency. The outcome of fetuses with CDH may be improved by fetal endoscopic tracheal occlusion (FETO). During pregnancy, fetal lungs secrete fluid into the …
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The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
Purpose: Tracheal occlusion (TO) reverses pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH), but its effect on epithelial-mesenchymal transition (EMT) in lung development remains poorly understood. The purpose of this study was to a) confirm the CDH rabbit model produced PH which …
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The use of inhaled nitric oxide to treat persistent pulmonary hypertension of the newborn in a tertiary public hospital in South Africa from 2010-2014: morbidity, mortality and cost
… for the treatment of severe persistent pulmonary hypertension of the newborn (PPHN) because it reduces the need for extracorporeal membrane oxygenation (ECMO). There is insufficient evidence that iNO reduces mortality in the absence of ECMO. Although neonates in some South African public …
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An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… enlarged, cystic kidneys, hepatic fibrosis and pulmonary hypoplasia, with death reported in around 30 – 50% of affected neonates. Mutations in PKHD1 and DZIP1L have been identified as causative genes for ARPKD, with the protein products of both genes localising to the primary cilium. Ciliary …
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Quantitative pathophysiology in rabbit models of early onset scoliosis and expansion thoracoplasty
… alveolarization leads to an irreversible loss of pulmonary growth and thoracic function. Consequently there is clinical incentive to treat children with growth-preserving therapies as early as possible. In particular thoracic reconstruction surgeries have gained clinical acceptance over the last …
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Impact of mechanical signals on human foetal lung cell differentiation
… the developing lung, are perturbed this leads to pulmonary hypoplasia and can result in neonatal morbidity and mortality. Part of the mechanism for these effects is that the sheer stress exerted by the amniotic fluid plays a role in alveolar differentiation as the pressure allows alveolar type I …