Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"pulmonary artery endothelial cells"”.
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The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells
… exerts protective effects in hypoxia-induced pulmonary hypertension (HPH) via endothelial cell estrogen receptor (ER)-dependent mechanisms. However, the effects of hypoxia on ER expression in the pulmonary-right ventricle (RV) axis remain unknown. Based on previous data suggesting a role of …
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Effect of shear stress on surface membrane potassium ion permeability of calf pulmonary artery endothelial cells (Potassium ion)
… potassium (K$\sp+$) permeability in vascular endothelial cells. Cultured monolayers of calf pulmonary artery endothelial cells, preloaded with $\rm \sp{86}Rb\sp+$, were subjected to different levels of fluid shear stress in the range 1-10 dynes/cm$\sp2$, in a parallel-plate geometry flow …
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Molecular and cellular mechanisms implicated in the regulation of cellular PMCA expression during pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare, life-threatening disorder typified by elevated pulmonary vascular resistance, right ventricular hypertrophy, right heart failure and ultimately death. This disease has no current cure and available therapies alleviate vasoconstriction but do not …
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Investigating the impact of gold nanoparticles on pulmonary cells: From 2D to 3D culture systems
… uptake of rods and rod widths in primary human pulmonary artery endothelial cells. We also investigated gold nanorod secretion kinetics in a 10 h interval. At the end of 10 h, > 75% of rods were removed from the cells. The impact of gold nanoparticle aerosols on human airway epithelium …
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HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
… One mechanism for this pathology may involve endothelial activation either by HIV itself or by its secreted proteins, gp120 (a viral envelope protein) and tat (a protein that upregulates transcription of viral genes). We have studied the effects of gp120 and tat on signaling and production of …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
Objective: Pulmonary arterial hypertension (PAH) is a disease of proliferative vascular occlusion that is strongly linked to heterozygous mutations in BMPR2, the gene encoding the bone morphogenetic protein (BMP) type II receptor (BMPR-II). The endothelial-selective BMPR-II ligand, BMP9, has been …
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The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
… in bovine embryonic lung fibroblasts, human pulmonary artery endothelial cells (HPAE) and bovine PAE cell lines were also studied. Our preliminary data suggest that inhibitors of protein and RNA synthesis both cause a significant decrease in the induction of the manganese SOD in bovine …
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Insights into the mechanisms of wound repair and the role of TP508 in tissue regeneration
… phosphatase PTP-PEST as a potential regulator of endothelial adherens junctions and the tissue repair peptide TP508 as a potential modulator of inflammatory-induced endothelial activation. Second, these experiments aimed to determine how TP508 promoted dermal wound healing using two models of …
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Pathogenesis of Fumonisin Toxicosis in Swine
… including leukoencephalomalacia in horses and pulmonary edema in pigs, but little is known about the pathogenesis of disease. Fumonisins inhibit ceramide synthase in the sphingolipid biosynthetic pathway, but the subsequent elevation of tissue sphingoid bases is not always associated with …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
The progressive disease, pulmonary arterial hypertension (PAH), occurs when the pulmonary vasculature pathologically remodels and constricts, causing increased pulmonary arterial pressure eventually leading to right heart failure. Loss of function mutations in the bone morphogenetic protein (BMP) …
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Metabolic changes in cellular components of the vasculature : examining the link between diabetes and cancer
… glycolytic' conditions exhibited by cancer cells and a study indicating a risk of developing cancer in non-obese persons with elevated fasting glucose levels, the presented work examines how the glucose metabolism of healthy cells is altered following exposure to biomolecules that are …