Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"pulmonary arterial hypertension"”.
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Symptom Burden and Healthcare Utilization in Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is a rapidly progressive disease. There is currently no cure; thus treatment is aimed at prolonging survival, improving functional status (FS), and symptom mitigation. Symptom burden (SB) can impact quality of life (QOL), and lead to increased …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare disease initiated by dysfunction of the pulmonary vascular endothelium. Mutations in BMPR2, which encodes the type-II bone morphogenic protein (BMP) receptor BMPR-II, explain the majority of heritable PAH. BMPR-II forms a signalling complex, with ALK1 …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a progressive disease which results from increases in mean pulmonary artery pressure and pulmonary vascular resistance. If untreated it leads to right ventricular failure and death. 5-Hydroxytryptamine (5-HT) has been implicated in the disease process and is …
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Deep learning of regulatory sequence variation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and fatal lung disease. To date, in only a third of idiopathic patients, the cause can be attributed to rare genetic variation in the protein-coding space. The sequencing of 13,343 whole genomes by the NIHR BioResource for Translational Research – …
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Development and Resolution of Pulmonary Arterial Hypertension in RAO Horses
… affected horses. Horses demonstrating severe pulmonary compromise develop concurrent secondary pulmonary hypertension. The development of pulmonary hypertension is well documented in RAO affected horses, however, it is not known how rapidly increases in pulmonary artery pressure occur after …
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Characterising ATP13A3 biological function and its role in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare but devastating disease characterised by the progressive remodelling of the small pulmonary vessels. Although the causes may vary, similar pathobiological features are shared among different forms of PAH, with endothelial dysfunction, the …
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
… of cardiovascular diseases, including pulmonary arterial hypertension (PAH), ischemia-reperfusion injury, cardiac hypertrophy, and heart failure. PAH is characterized by unrestricted proliferation and impaired apoptosis of pulmonary artery smooth muscle cells (PASMC), resulting in an …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
Background Pulmonary Arterial Hypertension (PAH) is a progressive vascular disease characterised by pulmonary vascular remodelling, inflammation, and excessive apoptosis of pulmonary arterial endothelial cells (PAECs). Elevated levels of pro- inflammatory cytokines such as TNF-α are a hallmark of …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a rare disease characterised by constriction and obliteration of small pulmonary arteries, which leads to increased pulmonary vascular resistance and in consequence, right ventricular failure and death. The accurate clinical diagnosis of pulmonary …
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Contribution of Causal Aquaporin-1 Mutations to the Pathobiology of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and debilitating disease characterised by elevated pulmonary arterial pressure and extensive vascular remodelling in the lungs, with a lack of effective curative options. The identification of genetic variations in genes encoding components of the …
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Phenotype – genotype associations in a large cohort of patients with pulmonary arterial hypertension
Idiopathic and heritable pulmonary arterial hypertension (PAH) are rare diseases with a poor prognosis. There is significant heterogeneity in clinical features at diagnosis, and in a proportion of patients there is a genetic cause of the disease. This clinical and genetic heterogeneity has hindered …
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Elucidating the roles of endothelial PTBP1 and PKM2 in Pulmonary Arterial Hypertension: implications for therapy
Pulmonary Arterial Hypertension (PAH) is a rare, life-limiting disease with no cure, and is regarded the most severe form of pulmonary hypertension (PH). The disease is characterised by remodelling of peripheral pulmonary arteries, leading to increased mean pulmonary arterial pressure, right …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… such as non-small cell lung cancer (NSCLC) and pulmonary arterial hypertension (PAH), due to increased DRP1 expression and activity. PAH is a progressive pulmonary vasculopathy that culminates in right ventricular failure (RVF). We identified two putative DRP1 inhibitors via in silico screening …
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Molecular and cellular mechanisms implicated in the regulation of cellular PMCA expression during pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare, life-threatening disorder typified by elevated pulmonary vascular resistance, right ventricular hypertrophy, right heart failure and ultimately death. This disease has no current cure and available therapies alleviate vasoconstriction but do not …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if left …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare fatal disease characterised by endothelial dysfunction and obliteration of small pulmonary arteries. The resulting increase in pulmonary arterial pressure and right ventricular afterload ultimately causes death by right heart failure. Current …
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Influences of first-line oral monotherapy on outcomes in Pulmonary Arterial Hypertension in association with Connective Tissue Disease.
Background Pulmonary arterial hypertension (PAH) is a rare progressive disease with no known cure. Of various aetiologies, PAH in association with connective tissue disease (PAH-CTD) is the most rapidly progressive and difficult to treat. Management of PAH has evolved significantly in the past ten …
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