Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"public health burden"”.
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Public health burden of diabetes in Ireland: time trends, determinants of complications and the implementation of a public health intervention to improve health outcomes for people with diabetes
Aim: To estimate the public health burden of diabetes in Ireland and to evaluate the implementation of a public health intervention to prevent and delay the development of a complication for people with diabetes. Methods: Data from four nationally representative studies were used to explore trends …
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The prevalence and risk factors associated with pulmonary arterial hypertension among HIV-infected individuals in a tertiary hospital in Durban
… (HIV) infection continues to be a major global public health burden and a risk factor for developing pulmonary arterial hypertension (PAH). Africa carries the largest burden of HIV globally. However, data summarizing the epidemiology of PAH remains unclear. The lungs are often affected by …
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Prevalence of shoulder morbidity after treatment for breast cancer in South Africa
… death among women and represents a considerable public health burden in South Africa and other low-middle income countries. Breast cancer management comprises single or combination treatment including surgery, radiotherapy and chemotherapy. Short and long-term complications of these treatments …
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Community acquired bacterial meningitis and meningococcal septicaemia amongst adults in England and Wales : epidemiology and clinical management
… vaccination; however mortality amongst otherwise healthy young adults remains high. <br></br><br></br><b>Objective:</b> I undertook this study to examine the way by which the public health burden of meningitis in adults can be reduced. <br></br><br></br><b>Methods:</b> I used routine surveillance …
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Depressive Symptoms and Distress Tolerance: Associations with Risky Sexual Behaviors
Risky sexual behaviors (RSB) are a significant public health concern in the United States. Better understanding factors related to RSB has important implications for the prevention of such behaviors and the alleviation of the corresponding public health burden. Depressive symptomatology has …
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Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization
… tuberculosis (Mtb). Globally, TB is a major public health burden with an estimated 10.4 million new cases and 1.8 million deaths reported in 2015. Although TB is curable, the treatment options currently available are beset by numerous shortcomings such as lengthy and complex treatment …
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Risk prediction models for hip fracture: parametric versus Cox regression
Hip fracture is a public health burden due to high morbidity, mortality and cost. Risk prediction models can aid clinical decision-making by identifying individuals at risk. Objective: To build risk prediction model for incident hip fracture using Weibull regression and compare this with Cox …
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Physiotherapy management of patients with Peripheral Artery Disease in the Western Cape
Peripheral artery disease is a growing public health burden of disability and death worldwide. This is especially the case in lower-income countries like South Africa. Peripheral artery disease is a risk factor for major cardiovascular events and a leading cause of non-traumatic lower limb …
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Population dynamics of infectious disease and pathogen evolution: modelling vaccine escape
… it is theoretically possible for the overall public health burden to be highest at intermediate vaccination coverages, but only if the relative adaptation rate in vaccinees is very high. Otherwise, vaccination reduces the overall public health burden.
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Child road trauma: a profile for children in New South Wales and evaluation of properly-used age-appropriate restraints as a countermeasure
Child road trauma poses a preventable public health burden to the community. This PhD research aimed to: 1) quantify the magnitude of child passenger injuries in New South Wales (NSW), Australia; 2) evaluate the effectiveness of different restraint use to prevent fatalities among child passengers; …
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Gene expression profiling approach towards enhancement of malaria vaccine development
… diseases in the world, posing an enormous public health burden with significant economic consequences. The development of vaccines that provide sterile protection against pathogenic infection by the Plasmodium parasites that cause malaria is thus a major global public health priority. This …
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Investigating the role of host genetic polymorphisms in periodontitis susceptibility in a Western Cape population
… steadily increased worldwide, creating a notable public health burden, especially in Africa. This complex, multifactorial disease often remains undiagnosed until irreversible periodontal damage has occurred. While microbial biofilm is key to the disease onset, the host’s immune-inflammatory …
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The association between oral health, related bacteria and gastrointestinal cancer risk and progression
Cancer is a worldwide public health burden, with an overall annual incidence of 18.1 million new cancer cases and 9.6 million deaths each year reported in 2018. Approximately one-third of these cases were attributable to cancers of the gastrointestinal (GI) tract. Cancer incidence and mortality …
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The Role of Sacsin as a Molecular Chaperone
… to protein misfolding, comprising a large public health burden. For example, the two most common neurodegenerative diseases, Alzheimer’s and Parkinson’s diseases, possess protein misfolding as a core component of their pathology. In order to properly fold, many proteins require the …
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A Tale of Two States: Texas v. California Firearm Mortality, Legislation, and Policies to Reduce Firearm-Related Violence in the United States
… day due to gun violence. This violence is a public health burden resulting in thousands of injuries and deaths every year. The age-adjusted firearm mortality rate per 100,000 from 2000-2015 ranges from 10.14-11.01 and is trending up. States address gun violence differently, either by …
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Integration of ear and hearing care services in low and middle-income health systems: a systematic review and qualitative synthesis
Hearing loss is a global public health burden and mostly affects those living in low and middle-income countries (LMICs). Hearing loss is expected to significantly increase without public health interventions. One approach to address ongoing challenges is the World Health Organisation's …
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Development and Evaluation of Internet Interventions for Obesity Treatment
… programs may be a viable method for reducing the public health burden of obesity. The purpose of this study was to evaluate the efficacy of the Internet for delivery of weight control programs. Participants (10M, 81F; age=40.9; BMI=29.0) were randomly assigned to receive Internet Behavior Therapy …
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Site-Specific Labelling of the Flavivirus Envelope Protein using Genetic Code Expansion
… viruses that constitute a significant global public health burden. The envelope protein (E) orchestrates the processes of virus assembly, budding, and entry into cells and is the primary target of neutralising antibodies. The E proteins arranged on the surface of the virion are not static and …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… hence leishmaniasis is a major global public health burden. Interestingly, not all infected people develop active disease showing that an in-depth understanding of immune mechanisms could allow clear criteria for developing alternate host- derived therapies. Leukotrienes (LTs), produced …
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Investigating the Valley Fever – Environment Relationship in the Western U.S.
… over the past two decades, creating an emerging public health burden. Studies have been conducted that attempt to elucidate the association between environmental conditions and the growth and dispersal of the pathogen, yet the specific ecology of and environmental precursors to the disease remain …
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